Search Results - "Pittman, R N"

Oxygen gradients in the microcirculation by Pittman, R. N.

“…Early in the last century August Krogh embarked on a series of seminal studies to understand the connection between tissue metabolism and mechanisms by which…”
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Inhibition of Akt Kinase by Cell-permeable Ceramide and Its Implications for Ceramide-induced Apoptosis by Zhou, H, Summers, S A, Birnbaum, M J, Pittman, R N

“…Ceramide is an important lipid messenger involved in mediating a variety of cell functions including apoptosis. However, mechanisms responsible for…”
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Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3 by Paulson, H.L, Perez, M.K, Trottier, Y, Trojanowski, J.Q, Subramony, S.H, Das, S.S, Vig, P, Mandel, J.-L, Fischbeck, K.H, Pittman, R.N

“…The mechanism of neurodegeneration in CAG/polyglutamine repeat expansion diseases is unknown but is thought to occur at the protein level. Here, in studies of…”
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A system for characterizing cellular and molecular events in programmed neuronal cell death by Pittman, RN, Wang, S, DiBenedetto, AJ, Mills, JC

“…A model system has been established in which PC12 cells are converted to neuronal-like cells that undergo transcription-dependent cell death following removal…”
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Ataxin-3 With an Altered Conformation That Exposes the Polyglutamine Domain Is Associated With the Nuclear Matrix by Perez, Matthew K., Paulsonl, Henry L., Pittman, Randall N.

“…Spinocerebellar ataxia type-3 or Machado-Joseph disease (SCA3/MJD) is a member of the CAG/poly-glutamine repeat disease family. In this family of disorders, a…”
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Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain by Paulson, H L, Das, S S, Crino, P B, Perez, M K, Patel, S C, Gotsdiner, D, Fischbeck, K H, Pittman, R N

“…Machado-Joseph disease (MJD) is one of at least six neurodegenerative diseases caused by expansion of a CAG repeat encoding a polyglutamine tract in the…”
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Temperature dependence of oxygen diffusion and consumption in mammalian striated muscle by Bentley, T B, Meng, H, Pittman, R N

“…This study investigated the effect of temperature on the oxygen diffusion coefficient (DO2) of hamster retractor muscle from 11 to 37 degrees C. DO2 was…”
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Determination of PO2 and its heterogeneity in single capillaries by Zheng, L, Golub, A S, Pittman, R N

“…We have applied the phosphorescence lifetime technique (Vanderkooi, J. M., G. Maniara, T. J. Green, and D. F. Wilson. J. Biol. Chem. 262: 5476-5482, 1987) to…”
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The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity by Burnett, Barrington, Li, Fusheng, Pittman, Randall N.

“…The ubiquitin-proteasome pathway is critically involved in the pathology of neurodegenerative diseases characterized by protein misfolding and aggregation…”
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Neuronal plasminogen activators: cell surface binding sites and involvement in neurite outgrowth by Pittman, RN, Ivins, JK, Buettner, HM

“…Sympathetic neurons release both urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA). A number of inhibitors of serine proteases have…”
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Arterioles supply oxygen to capillaries by diffusion as well as by convection by Ellsworth, M L, Pittman, R N

“…In the early part of this century, August Krogh proposed a model of oxygen transport in capillaries that assumes that all oxygen is delivered to the…”
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Influence of temperature on oxygen diffusion in hamster retractor muscle by Bentley, T B, Pittman, R N

“…A mathematical analysis by Popel et al. [Am. J. Physiol. 256 (Heart Circ. Physiol. 25): H921-H924, 1989] of in vivo data on arteriolar O2 loss suggested that…”
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Oxygen exchange in the microcirculation of hamster retractor muscle by Swain, D P, Pittman, R N

“…We determined percent hemoglobin oxygen saturation (SO2) in arterioles and venules of the hamster retractor muscle at rest. We found that SO2 decreased from…”
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PC12 cells overexpressing tissue plasminogen activator regenerate neurites to a greater extent and migrate faster than control cells in complex extracellular matrix by Pittman, R N, DiBenedetto, A J

“…PC12 cells were stably transfected with expression vectors containing rat tissue plasminogen activator (tPA) under control of either a cytomegalovirus or rous…”
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Effect of hemodilution on oxygen transport in arteriolar networks of hamster striated muscle by Kuo, L, Pittman, R N

“…Experiments were performed on the hamster cheek pouch retractor muscle to investigate the influence of isovolemic hemodilution on microcirculatory hemodynamics…”
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Ataxin-3 Is a Histone-binding Protein with Two Independent Transcriptional Corepressor Activities by Li, Fusheng, Macfarlan, Todd, Pittman, Randall N, Chakravarti, Debabrata

“…The mechanisms of pathology for the family of polyglutamine disease proteins are unknown; however, recently it was shown that several of these proteins inhibit…”
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Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation by Khandelwal, S R, Randad, R S, Lin, P S, Meng, H, Pittman, R N, Kontos, H A, Choi, S C, Abraham, D J, Schmidt-Ullrich, R

“…The in vivo effects on hemoglobin (Hb)-O2 affinity and tissue PO2 were investigated after intraperitoneal administration of…”
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Akt Regulates Cell Survival and Apoptosis at a Postmitochondrial Level by Zhou, Honglin, Li, Xin-Ming, Meinkoth, Judy, Pittman, Randall N.

“…Phosphoinositide 3 kinase/Akt pathway plays an essential role in neuronal survival. However, the cellular mechanisms by which Akt suppresses cell death and…”
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Survey of the fatty acid composition of peanut (Arachis hypogaea) germplasm and characterization of their epoxy and eicosenoic acids by Hammond, E.G. (Iowa State University, Ames, IA.), Duvick, D, Wang, T, Dodo, H, Pittman, R.N

“…Peanut (Arachis hypogaea) plant introductions (732) were analyzed for fatty acid composition. Palmitate varied from 8.2 to 15.1%, stearate 1.1 to 7.2%, oleate…”
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Rate of oxygen loss from arterioles is an order of magnitude higher than expected by Popel, A S, Pittman, R N, Ellsworth, M L

“…The experimental data on oxygen flux from arterioles in the hamster cheek pouch retractor muscle [L. Kuo and R. N. Pittman, Am. J. Physiol. 254 (Heart Circ…”
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