Search Results - "Pittman, Paul G"

Targeted Delivery of Cytotoxic NAMPT Inhibitors Using Antibody-Drug Conjugates by Neumann, Christopher S, Olivas, Kathleen C, Anderson, Martha E, Cochran, Julia H, Jin, Steven, Li, Fu, Loftus, Luke V, Meyer, David W, Neale, Jason, Nix, Jay C, Pittman, Paul G, Simmons, Jessica K, Ulrich, Michelle L, Waight, Andrew B, Wong, Abbie, Zaval, Margo C, Zeng, Weiping, Lyon, Robert P, Senter, Peter D

“…Antibody-drug conjugates (ADCs) are a therapeutic modality that enables the targeted delivery of cytotoxic drugs to cancer cells. Identification of active…”
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Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation by Simmons, Jessica K., Burke, Patrick J., Cochran, Julia H., Pittman, Paul G, Lyon, Robert P.

“…Recently, we described a family of non-targeting monomethylauristatin E (MMAE) antibody-drug conjugates (ADCs) whose pharmacokinetics could be tuned through…”
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Parental and larval exposure to nicotine modulate spontaneous activity as well as cholinergic and GABA receptor expression in adult C. elegans by Rose, Jacqueline K, Miller, Miranda K, Crane, Stephanie A, Hope, Kevin A, Pittman, Paul G

“…Abstract Early nicotine exposure has been associated with many long-term consequences that include neuroanatomical alterations, as well as behavioral and…”
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Abstract 930: Targeted delivery of cytotoxic NAMPT inhibitors using antibody-drug conjugates by Neumann, Christopher S., Olivas, Kathleen C., Waight, Andrew B., Meyer, David, Loftus, Luke V., Zaval, Margo, Anderson, Martha E., Jin, Steven, Cochran, Julia H., Simmons, Jessica K., Pittman, Paul G., Lyon, Robert P., Senter, Peter D.

“…Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme involved in the salvage biosynthetic pathway of NAD from nicotinamide…”
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Abstract 983: Antibody-drug conjugates of NAMPT inhibitors: Discovery, optimization, and preclinical characterization by Neumann, Chris, Olivas, Kathleen C., Wang, Kung Pern, Waight, Andrew B., Meyer, David W., Loftus, Luke V., Zaval, Margo C., Anderson, Martha E., Jin, Steven, Cochran, Julia H., Simmons, Jessica K., Pittman, Paul G., Li, Fu, Ulrich, Michelle L., Wong, Abbie, Zeng, Weiping, Lyon, Robert P., Senter, Peter D.

“…Nicotinamide phosphoribosyltransferase (NAMPT) regulates the biosynthesis of NAD from nicotinamide via a salvage biosynthetic pathway. Inhibition of NAMPT…”
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