Search Results - "Pitti, Robert"

Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling by Jin, Zhaoyu, Li, Yun, Pitti, Robert, Lawrence, David, Pham, Victoria C., Lill, Jennie R., Ashkenazi, Avi

“…Cell-surface death receptors such as DR4 and DR5 trigger apoptosis through a death-inducing signaling complex (DISC) that recruits the apical protease…”
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An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells by Vinogradova, Maia, Gehling, Victor S, Gustafson, Amy, Arora, Shilpi, Tindell, Charles A, Wilson, Catherine, Williamson, Kaylyn E, Guler, Gulfem D, Gangurde, Pranoti, Manieri, Wanda, Busby, Jennifer, Flynn, E Megan, Lan, Fei, Kim, Hyo-jin, Odate, Shobu, Cochran, Andrea G, Liu, Yichin, Wongchenko, Matthew, Yang, Yibin, Cheung, Tommy K, Maile, Tobias M, Lau, Ted, Costa, Michael, Hegde, Ganapati V, Jackson, Erica, Pitti, Robert, Arnott, David, Bailey, Christopher, Bellon, Steve, Cummings, Richard T, Albrecht, Brian K, Harmange, Jean-Christophe, Kiefer, James R, Trojer, Patrick, Classon, Marie

“…KDM5 histone demethylases promote the survival of drug-tolerant persister (DTP) cells in certain cancers. CPI-455, a chemical probe specific for KDM5, elevates…”
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Repression of Stress-Induced LINE-1 Expression Protects Cancer Cell Subpopulations from Lethal Drug Exposure by Guler, Gulfem Dilek, Tindell, Charles Albert, Pitti, Robert, Wilson, Catherine, Nichols, Katrina, KaiWai Cheung, Tommy, Kim, Hyo-Jin, Wongchenko, Matthew, Yan, Yibing, Haley, Benjamin, Cuellar, Trinna, Webster, Joshua, Alag, Navneet, Hegde, Ganapati, Jackson, Erica, Nance, Tracy Leah, Giresi, Paul Garrett, Chen, Kuan-Bei, Liu, Jinfeng, Jhunjhunwala, Suchit, Settleman, Jeff, Stephan, Jean-Philippe, Arnott, David, Classon, Marie

“…Maintenance of phenotypic heterogeneity within cell populations is an evolutionarily conserved mechanism that underlies population survival upon stressful…”
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Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL by Ashkenazi, Avi, Lancaster, Kate, Punnoose, Elizabeth A, Lee, Dori, Pitti, Robert M, Lawrence, David A, Totpal, Klara, Hymowitz, Sarah G, Cavet, Guy, Huw, Ling, Wagner, Klaus W, von Goetz, Melissa, Yee, Sharon Fong, Katta, Viswanatham, Amler, Lukas, Januario, Thomas

“…Apo2L/TRAIL stimulates cancer cell death through the proapoptotic receptors DR4 and DR5, but the determinants of tumor susceptibility to this ligand are not…”
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Proapoptotic Activation of Death Receptor 5 on Tumor Endothelial Cells Disrupts the Vasculature and Reduces Tumor Growth by Wilson, Nicholas S., Yang, Annie, Yang, Becky, Couto, Suzana, Stern, Howard, Gogineni, Alvin, Pitti, Robert, Marsters, Scot, Weimer, Robby M., Singh, Mallika, Ashkenazi, Avi

“…The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we…”
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Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors by Sheridan, James P., Marsters, Scot A., Pitti, Robert M., Gurney, Austin, Skubatch, Maya, Baldwin, Daryl, Ramakrishnan, Lakshmi, Gray, Christa L., Baker, Kevin, Wood, William I., Goddard, Audrey D., Godowski, Paul, Ashkenazi, Avi

“…TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4…”
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Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer by Ashkenazi, Avi, Pitti, Robert M, Marsters, Scot A, Lawrence, David A, Roy, Margaret, Kischkel, Frank C, Dowd, Patrick, Huang, Arthur, Donahue, Christopher J, Sherwood, Steven W, Baldwin, Daryl T, Godowski, Paul J, Wood, William I, Gurney, Austin L, Hillan, Kenneth J, Cohen, Robert L, Goddard, Audrey D, Botstein, David

“…Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death…”
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Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI by Marsters, Scot A, Yan, Minhong, Pitti, Robert M, Haas, Philip E, Dixit, Vishva M, Ashkenazi, Avi

“…BLyS (also called TALL-1, THANK, or BAFF) [1–4] is a member of the tumor necrosis factor (TNF) gene family that stimulates proliferation and immunoglobulin…”
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Complementary Proteomic Tools for the Dissection of Apoptotic Proteolysis Events by Pham, Victoria C, Pitti, Robert, Anania, Veronica G, Bakalarski, Corey E, Bustos, Daisy, Jhunjhunwala, Suchit, Phung, Qui T, Yu, Kebing, Forrest, William F, Kirkpatrick, Donald S, Ashkenazi, Avi, Lill, Jennie R

“…Proteolysis is a key regulatory event that controls intracellular and extracellular signaling through irreversible changes in a protein’s structure that…”
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Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family by Pitti, R M, Marsters, S A, Ruppert, S, Donahue, C J, Moore, A, Ashkenazi, A

“…Cytokines in the tumor necrosis factor (TNF) family regulate development and function of the immune system. We have isolated a new member of this family,…”
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Identification of a ligand for the death-domain-containing receptor Apo3 by Marsters, Scot A., Sheridan, James P., Pitti, Robert M., Brush, Jennifer, Goddard, Audrey, Ashkenazi, Avi

“…The tumor necrosis factor (TNF) cytokine family regulates development and function of the immune system [1]. TNF is expressed primarily by activated…”
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Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA by Marsters, Scot A., Pitti, Robert M., Donahue, Christopher J., Ruppert, Siegfried, Bauer, Kenneth D., Ashkenazi, Avi

“…A new member of the tumor necrosis factor (TNF) cytokine family, designated Apo-2 ligand (Apo-2L) [1] or TRAIL [2], has been shown recently to induce apoptosis…”
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TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer by Gonzalvez, Francois, Lawrence, David, Yang, Becky, Yee, Sharon, Pitti, Robert, Marsters, Scot, Pham, Victoria C., Stephan, Jean-Philippe, Lill, Jennie, Ashkenazi, Avi

“…Apoptotic caspase activation mechanisms are well defined, yet inactivation modes remain unclear. The death receptors (DRs), DR4, DR5, and Fas, transduce…”
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An Fcγ Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling in Cancer Cells by Wilson, Nicholas S., Yang, Becky, Yang, Annie, Loeser, Stefanie, Marsters, Scot, Lawrence, David, Li, Yun, Pitti, Robert, Totpal, Klara, Yee, Sharon, Ross, Sarajane, Vernes, Jean-Michel, Lu, Yanmei, Adams, Cam, Offringa, Rienk, Kelley, Bob, Hymowitz, Sarah, Daniel, Dylan, Meng, Gloria, Ashkenazi, Avi

“…Antibodies to cell-surface antigens trigger activatory Fcγ receptor (FcγR)-mediated retrograde signals in leukocytes to control immune effector functions…”
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Proteomic Analyses Identify a Novel Role for EZH2 in the Initiation of Cancer Cell Drug Tolerance by Pham, Victoria, Pitti, Robert, Tindell, Charles A, Cheung, Tommy K, Masselot, Alexandre, Stephan, Jean-Phillipe, Guler, Gulfem D, Wilson, Catherine, Lill, Jennie, Arnott, David, Classon, Marie

“…Acquisition of drug resistance remains a chief impediment to successful cancer therapy, and we previously described a transient drug-tolerant cancer cell…”
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At play in the briar patch of epigenetics by Kiefer, Jim, Trojer, Patrick, Classon, Marie, Vinogradova, Maia, Gehling, Victor, Arora, Shilpi, Gustafson, Amy, Albrecht, Brian, Tindell, Charles, Williamson, Kaylyn, Wilson, Catherine, Busby, Jennifer, Liu, Yichin, Gangurde, Pranoti, Arnott, David, Buker, Shane, Cheung, Tommy, Lan, Fei, Jackson, Erica, Flynn, Megan, Cochran, Andrea, Maille, Tobias, Guler, Gulfem, Bailey, Christopher, Cummings, Richard, Pitti, Robert, Wongchenko, Matthew, Yang, Yibing, Lau, Ted, Costa, Mike, Harmange, Jean-Christophe, Settleman, Jeffrey

“…Abstract only…”
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An FcI[sup3 Receptor-Dependent Mechanism Drives Antibody-Mediated Target-Receptor Signaling inaaCancer Cells by Wilson, Nicholas S, Yang, Becky, Yang, Annie, Loeser, Stefanie, Marsters, Scot, Lawrence, David, Li, Yun, Pitti, Robert, Totpal, Klara, Yee, Sharon, Ross, Sarajane, Vernes, Jean-Michel, Lu, Yanmei, Adams, Cam, Offringa, Rienk, Kelley, Bob, Hymowitz, Sarah, Daniel, Dylan, Meng, Gloria, Ashkenazi, Avi

“…Antibodies to cell-surface antigens trigger activatory FcI[sup3 receptor (FcI[sup3R)-mediated retrograde signals in leukocytes to control immune effector…”
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Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB by Marsters, Scot A., Sheridan, James P., Donahue, Christopher J., Pitti, Robert M., Gray, Christa L., Goddard, Audrey D., Bauer, Kenneth D., Ashkenazi, Avi

“…Background Two receptors that contain the so-called ‘death domain’ have been described to date: tumor necrosis factor receptor 1 (TNFR1) and Fas/Apo-1 (CD95);…”
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Platelet Glycoprotein IIb-IIIa Protein Antagonists from Snake Venoms: Evidence for a Family of Platelet-Aggregation Inhibitors by Dennis, Mark S., Henzel, William J., Pitti, Robert M., Lipari, Michael T., Napier, Mary A., Deisher, Theresa A., Bunting, Stuart, Lazarus, Robert A.

“…The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins that are platelet…”
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Control of apoptosis signaling by Apo2 ligand by Marsters, S A, Pitti, R A, Sheridan, J P, Ashkenazi, A

“…Apo2 ligand (Apo2L, also called TRAIL) is a member of the tumor necrosis factor (TNF) cytokine family. The closest homolog of Apo2L is CD95 (Fas/Apo1) ligand,…”
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