Search Results - "Pitti, R M"

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors by Sheridan, James P., Marsters, Scot A., Pitti, Robert M., Gurney, Austin, Skubatch, Maya, Baldwin, Daryl, Ramakrishnan, Lakshmi, Gray, Christa L., Baker, Kevin, Wood, William I., Goddard, Audrey D., Godowski, Paul, Ashkenazi, Avi

“…TRAIL (also called Apo2L) belongs to the tumor necrosis factor family, activates rapid apoptosis in tumor cells, and binds to the death-signaling receptor DR4…”
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A novel receptor for Apo2L/TRAIL contains a truncated death domain by Marsters, S A, Sheridan, J P, Pitti, R M, Huang, A, Skubatch, M, Baldwin, D, Yuan, J, Gurney, A, Goddard, A D, Godowski, P, Ashkenazi, A

“…Apo2 ligand (Apo2L [1], also called TRAIL for tumor necrosis factor (TNF)-related apoptosis-inducing ligand [2]) belongs to the TNF family and activates…”
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Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer by Ashkenazi, Avi, Pitti, Robert M, Marsters, Scot A, Lawrence, David A, Roy, Margaret, Kischkel, Frank C, Dowd, Patrick, Huang, Arthur, Donahue, Christopher J, Sherwood, Steven W, Baldwin, Daryl T, Godowski, Paul J, Wood, William I, Gurney, Austin L, Hillan, Kenneth J, Cohen, Robert L, Goddard, Audrey D, Botstein, David

“…Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death…”
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Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR by Gurney, A.L., Marsters, S.A., Huang, A., Pitti, R.M., Mark, M., Baldwin, D.T., Gray, A.M., Dowd, P., Brush, J., Heldens, S., Schow, P., Goddard, A.D., Wood, W.I., Baker, K.P., Godowski, P.J., Ashkenazi, A.

“…The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation,…”
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Platelet Glycoprotein IIb-IIIa Protein Antagonists from Snake Venoms: Evidence for a Family of Platelet-Aggregation Inhibitors by Dennis, Mark S., Henzel, William J., Pitti, Robert M., Lipari, Michael T., Napier, Mary A., Deisher, Theresa A., Bunting, Stuart, Lazarus, Robert A.

“…The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins that are platelet…”
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Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI by Marsters, Scot A, Yan, Minhong, Pitti, Robert M, Haas, Philip E, Dixit, Vishva M, Ashkenazi, Avi

“…BLyS (also called TALL-1, THANK, or BAFF) [1–4] is a member of the tumor necrosis factor (TNF) gene family that stimulates proliferation and immunoglobulin…”
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Identification of a ligand for the death-domain-containing receptor Apo3 by Marsters, Scot A., Sheridan, James P., Pitti, Robert M., Brush, Jennifer, Goddard, Audrey, Ashkenazi, Avi

“…The tumor necrosis factor (TNF) cytokine family regulates development and function of the immune system [1]. TNF is expressed primarily by activated…”
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Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB by Marsters, Scot A., Sheridan, James P., Donahue, Christopher J., Pitti, Robert M., Gray, Christa L., Goddard, Audrey D., Bauer, Kenneth D., Ashkenazi, Avi

“…Background Two receptors that contain the so-called ‘death domain’ have been described to date: tumor necrosis factor receptor 1 (TNFR1) and Fas/Apo-1 (CD95);…”
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Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA by Marsters, Scot A., Pitti, Robert M., Donahue, Christopher J., Ruppert, Siegfried, Bauer, Kenneth D., Ashkenazi, Avi

“…A new member of the tumor necrosis factor (TNF) cytokine family, designated Apo-2 ligand (Apo-2L) [1] or TRAIL [2], has been shown recently to induce apoptosis…”
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Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family by Pitti, R M, Marsters, S A, Ruppert, S, Donahue, C J, Moore, A, Ashkenazi, A

“…Cytokines in the tumor necrosis factor (TNF) family regulate development and function of the immune system. We have isolated a new member of this family,…”
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Molecular and biological properties of an interleukin-1 receptor immunoadhesin by Pitti, R M, Marsters, S A, Haak-Frendscho, M, Osaka, G C, Mordenti, J, Chamow, S M, Ashkenazi, A

“…Overproduction of the cytokine interleukin 1 (IL-1) is an important factor in the pathogenesis of several autoimmune and inflammatory disease. To develop a…”
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Identification of a new member of the tumor necrosis factor family and its receptor, a human orthology of mouse GITR by Gurney, AL, Marsters, SA, Huang, A, Pitti, R M, Mark, M, Baldwin, D T, Gray, A M, Dowd, P, Brush, J, Heldens, S, Schow, P, Goddard, AD, Wood, W I, Baker, K P

“…The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate diverse biological functions, including cell proliferation,…”
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Cyclic RGD peptide analogs as antiplatelet antithrombotics by Barker, Peter L, Bullens, Sherron, Bunting, Stuart, Burdick, Daniel J, Chan, Kathryn S, Deisher, Tracy, Eigenbrot, Charles, Gadek, Thomas R, Gantzos, Robin

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Cyclic RGD peptide analogues as antiplatelet antithrombotics by Barker, P L, Bullens, S, Bunting, S, Burdick, D J, Chan, K S, Deisher, T, Eigenbrot, C, Gadek, T R, Gantzos, R, Lipari, M T

“…Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation. GPIIbIIIa/Fg…”
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