Protective effects of amburoside A, a phenol glucoside from Amburana cearensis, against CCl4-induced hepatotoxicity in rats

The aim of this study was to investigate the possible beneficial effects of amburoside A, AMB [4-(O-beta- D-glycopyranosyl)benzyl protocatechoate], against carbon tetrachloride (CCl (4)) toxicity in rats. AMB is a phenol glucoside from the Brazilian medicinal plant Amburana cearensis, popularly used...

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Bibliographic Details
Published in:	Planta medica Vol. 74; no. 5; p. 497
Main Authors:	Leal, Luzia K, Fonseca, Francisco Noé, Pereira, Fábio Azevedo, Canuto, Kirley M, Felipe, Cícero F, Fontenele, Juvênia Bezerra, Pitombeira, Márcia V, Silveira, Edilberto R, Viana, Glauce S
Format:	Journal Article
Language:	English
Published:	Germany 01-04-2008
Subjects:	Alanine Transaminase - blood Animals Aspartate Aminotransferases - blood Carbon Tetrachloride Carbon Tetrachloride Poisoning - drug therapy Carbon Tetrachloride Poisoning - metabolism Carbon Tetrachloride Poisoning - pathology Catalase - metabolism Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - pathology Chemical and Drug Induced Liver Injury - prevention & control Fabaceae - chemistry Glucosides - isolation & purification Glucosides - therapeutic use Glutathione - metabolism Liver - enzymology Liver - metabolism Liver - pathology Male Phytotherapy Plant Extracts - chemistry Plant Extracts - therapeutic use Rats Rats, Wistar Thiobarbituric Acid Reactive Substances - metabolism
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Summary:	The aim of this study was to investigate the possible beneficial effects of amburoside A, AMB [4-(O-beta- D-glycopyranosyl)benzyl protocatechoate], against carbon tetrachloride (CCl (4)) toxicity in rats. AMB is a phenol glucoside from the Brazilian medicinal plant Amburana cearensis, popularly used for the treatment of respiratory tract affections. Acute AMB (25 and 50 mg/kg, I. P. or P. O.) treatments of CCl (4)-intoxicated rats significantly inhibited the increase in serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, as compared to the group treated with CCl (4) only. Histological studies showed less centrolobular necrosis and inflammatory cell infiltrates in the liver of animals treated with AMB plus CCl (4), when compared to the group treated with CCl (4) alone. In hepatic tissues, AMB at both doses inhibited CCl (4)-induced thiobarbituric acid-reactive substances (TBARS) formation, indicating a blockade of CCl (4)-induced lipid peroxidation. AMB also reversed the decrement in glutathione contents of hepatic tissues in CCl (4)-intoxicated rats. Furthermore, it restored catalase activity to normal values, which was significantly increased after CCl (4) treatment. Our results indicate that CCl (4)-induced oxidative damage in hepatic tissues is reversed by AMB treatment. The protective effect of AMB is probably due to the phenolic nature of this glucoside.
ISSN:	0032-0943
DOI:	10.1055/s-2008-1074501