Search Results - "Pitha, P M"

Unique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response by Fang, C-M, Roy, S, Nielsen, E, Paul, M, Maul, R, Paun, A, Koentgen, F, Raval, F M, Szomolanyi-Tsuda, E, Pitha, P M

“…IRF-5 is a transcription factor activated by toll like receptor (TLR)7 and TLR9 during innate immune responses. IRF-5 activates not only Type I IFN, but also…”
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Primary Activation of Interferon A and Interferon B Gene Transcription by Interferon Regulatory Factor 3 by Y.-T. Juang, Lowther, W., Kellum, M., W.-C. Au, Lin, R., Hiscott, J., Pitha, P. M.

“…The family of interferon (IFN) regulatory factors (IRFs) encodes DNA-binding transcription factors, some of which function as modulators of virus-induced…”
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Type I interferon: the ever unfolding story by Pitha, P M, Kunzi, M S

“…Since the discovery of interferon 50 years ago, the understanding of the mechanism of the virus-mediated induction of type I IFN and its function has been…”
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Characterization of a Novel Human Herpesvirus 8-Encoded Protein, vIRF-3, That Shows Homology to Viral and Cellular Interferon Regulatory Factors by Lubyova, B, Pitha, P M

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The IRF family, revisited by Paun, A., Pitha, P.M.

“…Since the discovery of interferon 50 years ago a great deal of progress has been made in understanding how interferons work and how and why they are induced…”
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Latently Expressed Human Herpesvirus 8-Encoded Interferon Regulatory Factor 2 Inhibits Double-Stranded RNA-Activated Protein Kinase by Burýšek, Ladislav, Pitha, Paula M.

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Production of Tumor Necrosis Factor and Other Cytokines by Astrocytes Stimulated with Lipopolysaccharide or a Neurotropic Virus by Lieberman, Andrew P., Pitha, Paula M., Shin, Hyun S., Shin, Moon L.

“…Rat astrocytes, immunologically competent glial cells of the central nervous system (CNS), released a variety of cytokines after activation…”
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E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas by GRAFF, J. R, HERMAN, J. G, LAPIDUS, R. G, CHOPRA, H, XU, R, JARRARD, D. F, ISAACS, W. B, PITHA, P. M, DAVIDSON, N. E, BAYLIN, S. B

“…Expression of the Ca(2+)-dependent, homotypic cell:cell adhesion molecule, E-cadherin (E-cad), suppresses tumor cell invasion and metastasis in experimental…”
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Identification of a Member of the Interferon Regulatory Factor Family that Binds to the Interferon-Stimulated Response Element and Activates Expression of Interferon-Induced Genes by Au, Wei-Chun, Moore, Paul A., Lowther, William, Juang, Yuang-Taung, Pitha, Paula M.

“…A family of interferon (IFN) regulatory factors (IRFs) have been shown to play role in transcription of IFN genes as well as IFN-stimulated genes. We report…”
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Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle by SHIRAZI, Y, PITHA, P. M

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Analysis of Functional Domains of Interferon Regulatory Factor 7 and Its Association with IRF-3 by Au, W.-C., Yeow, W.-S., Pitha, P.M.

“…IRF-7 plays an essential role in virus-activated transcription of IFNA genes. To analyze functional domains of IRF-7 we have constructed an amino-terminal…”
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Role of the interferon regulatory factors (IRFs) in virus-mediated signaling and regulation of cell growth by Pitha, Paula M., Au, Wei-C., Lowther, William, Juang, Yuang-T., Schafer, Susan L., Burysek, Ladislaw, Hiscott, John, Moore, Paul A.

“…As a response to viral infection, cells express the early inflammatory genes that encode small proteins generally called cytokines or chemokines. These protein…”
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LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF by Fitzgerald, Katherine A., Rowe, Daniel C., Barnes, Betsy J., Caffrey, Daniel R., Visintin, Alberto, Latz, Eicke, Monks, Brian, Pitha, Paula M., Golenbock, Douglas T.

“…Toll–IL-1–resistance (TIR) domain–containing adaptor-inducing IFN-β (TRIF)–related adaptor molecule (TRAM) is the fourth TIR domain–containing adaptor protein…”
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Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway by Popik, Waldemar, Pitha, Paula M.

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The IRS-pathway operates distinctively from the stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-α receptors by UDDIN, S, FISH, E. N, SHER, D, GARDZIOLA, C, COLAMONICI, O. R, KELLUM, M, PITHA, P. M, WHITE, M. F, PLATANIAS, L. C

“…Binding of interferon-alpha (IFN-alpha) to its receptor on hematopoietic cells activates the signal transducers and activators of transcription (Stat)- and…”
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ISG15 enhances the innate antiviral response by inhibition of IRF-3 degradation by Lu, G, Reinert, J T, Pitha-Rowe, I, Okumura, A, Kellum, M, Knobeloch, K P, Hassel, B, Pitha, P M

“…The transcription factor, interferon regulatory Factor 3 (IRF-3) plays a critical role in the activation of an antiviral innate immune response. However the…”
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A Conditionally Replicating HIV-1 Vector Interferes with Wild-Type HIV-1 Replication and Spread by Dropulić, Boro, Hěrmánková, Monika, Pitha, Paula M.

“…Defective-interfering viruses are known to modulate virus pathogenicity. We describe conditionally replicating HIV-1 (crHIV) vectors that interfere with…”
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Molecular Basis for the Immunostimulatory Activity of Guanine Nucleoside Analogs: Activation of Toll-like Receptor 7 by Lee, Jongdae, Chuang, Tsung-Hsien, Redecke, Vanessa, She, Liping, Pitha, Paula M., Carson, Dennis A., Raz, Eyal, Cottam, Howard B.

“…Certain C8-substituted and N7, C8-disubstituted guanine ribonucleosides comprise a class of small molecules with immunostimulatory activity. In a variety of…”
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Stimulation of interferon and cytokine gene expression by imiquimod and stimulation by Sendai virus utilize similar signal transduction pathways by Megyeri, Klara, Au, Wei-Chun, Rosztoczy, Istvan, Raj, N. Babu K., Miller, Richard L., Tomai, Mark A., Pitha, Paula M.

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Activation of Human Immunodeficiency Virus by Herpesvirus Infection: Identification of a Region within the Long Terminal Repeat that Responds to a Trans-Acting Factor Encoded by Herpes Simplex Virus 1 by Mosca, J. D., Bednarik, D. P., Raj, N. B. K., Rosen, C. A., Sodroski, J. G., Haseltine, W. A., Hayward, G. S., Pitha, P. M.

“…Herpes simplex virus 1 (HSV-1) infection induces transcription of the chloramphenicol acetyltransferase (CAT) gene directed by the long terminal repeat (LTR)…”
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