Search Results - "Pitchford, Lisa M"

Metabolic dysfunction in obesity is related to impaired suppression of fatty acid release from adipose tissue by insulin by Schleh, Michael W., Ryan, Benjamin J., Ahn, Cheehoon, Ludzki, Alison C., Varshney, Pallavi, Gillen, Jenna B., Van Pelt, Douglas W., Pitchford, Lisa M., Howton, Suzette M., Rode, Thomas, Chenevert, Thomas L., Hummel, Scott L., Burant, Charles F., Horowitz, Jeffrey F.

“…Objective The aims of this study were: 1) to assess relationships among insulin‐mediated glucose uptake with standard clinical outcomes and deep‐phenotyping…”
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Subchronic (90-day) repeated dose toxicity study of 2-hydroxybenzylamine acetate in rats by Fuller, John C., Pitchford, Lisa M., Abumrad, Naji N., Rathmacher, John A.

“…2-Hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, can protect cells and tissues from oxidative stress. In this study, 2-HOBA…”
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Small-Scale Randomized Controlled Trial to Explore the Impact of β-Hydroxy-β-Methylbutyrate Plus Vitamin D3 on Skeletal Muscle Health in Middle Aged Women by Fairfield, William D., Minton, Dennis M., Elliehausen, Christian J., Nichol, Alexander D., Cook, Taylor L., Rathmacher, John A., Pitchford, Lisa M., Paluska, Scott A., Kuchnia, Adam J., Allen, Jacob M., Konopka, Adam R.

“…β-Hydroxy-β-methylbutyrate (HMB), a leucine metabolite, can increase skeletal muscle size and function. However, HMB may be less effective at improving muscle…”
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2-Hydroxybenzylamine (2-HOBA) to prevent early recurrence of atrial fibrillation after catheter ablation: protocol for a randomized controlled trial including detection of AF using a wearable device by O'Neill, Matthew J, Yoneda, Zachary T, Crawford, Diane M, Ye, Fei, Ao, Mingfang, Pitchford, Lisa M, Rathmacher, John A, Murray, Katherine T, Akers, Wendell S, Roden, Dan M, Michaud, Gregory F, Shoemaker, M Benjamin

“…Although catheter ablation is an effective therapy for atrial fibrillation (AF), the most common cardiac arrhythmia encountered in clinical practice, AF…”
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Safety, tolerability, and pharmacokinetics of repeated oral doses of 2-hydroxybenzylamine acetate in healthy volunteers: a double-blind, randomized, placebo-controlled clinical trial by Pitchford, Lisa M, Driver, Patricia M, Fuller, Jr, John C, Akers, Wendell S, Abumrad, Naji N, Amarnath, Venkataraman, Milne, Ginger L, Chen, Sheau-Chiann, Ye, Fei, Roberts, 2nd, L Jackson, Shoemaker, M Benjamin, Oates, John A, Rathmacher, John A, Boutaud, Olivier

“…2-Hydroxybenzylamine (2-HOBA) is a selective dicarbonyl electrophile scavenger being developed as a nutritional supplement to help protect against the…”
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First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers by Pitchford, Lisa M, Rathmacher, John A, Fuller, Jr, John C, Daniels, J Scott, Morrison, Ryan D, Akers, Wendall S, Abumrad, Naji N, Amarnath, Venkataraman, Currey, Patricia M, Roberts, L Jackson, Oates, John A, Boutaud, Olivier

“…2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these…”
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Moderate-Intensity Exercise and High-Intensity Interval Training Affect Insulin Sensitivity Similarly in Obese Adults by Ryan, Benjamin J, Schleh, Michael W, Ahn, Cheehoon, Ludzki, Alison C, Gillen, Jenna B, Varshney, Pallavi, Van Pelt, Douglas W, Pitchford, Lisa M, Chenevert, Thomas L, Gioscia-Ryan, Rachel A, Howton, Suzette M, Rode, Thomas, Hummel, Scott L, Burant, Charles F, Little, Jonathan P, Horowitz, Jeffrey F

“…Abstract Objective We compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on insulin sensitivity…”
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Exercise training remodels subcutaneous adipose tissue in adults with obesity even without weight loss by Ahn, Cheehoon, Ryan, Benjamin J., Schleh, Michael W., Varshney, Pallavi, Ludzki, Alison C., Gillen, Jenna B., Van Pelt, Douglas W., Pitchford, Lisa M., Howton, Suzette M., Rode, Thomas, Hummel, Scott L., Burant, Charles F., Little, Jonathan P., Horowitz, Jeffrey F.

“…Excessive adipose tissue mass underlies much of the metabolic health complications in obesity. Although exercise training is known to improve metabolic health…”
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Long-term Effects of Calcium β-Hydroxy-β-Methylbutyrate and Vitamin D3 Supplementation on Muscular Function in Older Adults With and Without Resistance Training: A Randomized, Double-blind, Controlled Study by Rathmacher, John A, Pitchford, Lisa M, Khoo, Paul, Angus, Hector, Lang, James, Lowry, Kristin, Ruby, Carol, Krajek, Alex C, Fuller, John C, Sharp, Rick L

“…Abstract The primary aim of this study was to determine whether supplementation with calcium β-hydroxy-β-methylbutyrate (HMB) and vitamin D3 (D) would enhance…”
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Energy Deficit Required for Exercise-induced Improvements in Glycemia the Next Day by SCHLEH, MICHAEL W., PITCHFORD, LISA M., GILLEN, JENNA B., HOROWITZ, JEFFREY F.

“…PURPOSEThis study determined the impact of an exercise-induced energy deficit on postprandial and 24 h glycemic control the day after a session of exercise…”
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Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity by Schleh, Michael W, Ahn, Cheehoon, Ryan, Benjamin J, Chugh, Olivia K, Luker, Austin T, Luker, Kathryn E, Gillen, Jenna B, Ludzki, Alison C, Van Pelt, Douglas W, Pitchford, Lisa M, Zhang, Tao, Rode, Thomas, Howton, Suzette M, Burant, Charles F, Horowitz, Jeffrey F

“…Exercise training modifies lipid metabolism in skeletal muscle, but the effect of exercise training on intramyocellular lipid droplet (LD) abundance, size, and…”
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Impaired suppression of fatty acid release by insulin is a strong predictor of reduced whole‐body insulin‐mediated glucose uptake and skeletal muscle insulin receptor activation by Schleh, Michael W., Ryan, Benjamin J., Ahn, Cheehoon, Ludzki, Alison C., Van Pelt, Douglas W., Pitchford, Lisa M., Chugh, Olivia K., Luker, Austin T., Luker, Kathryn E., Samovski, Dmitri, Abumrad, Nada A., Burant, Charles F., Horowitz, Jeffrey F.

“…Abstract Aim To examine factors underlying why most, but not all, adults with obesity exhibit impaired insulin‐mediated glucose uptake, we compared: (1)…”
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Impact of beta-Hydroxy-beta-methylbutyrate plus Vitamin D 3 Supplementation on Skeletal Muscle Size, Function and Quality in Sedentary and Resistance Exercise Trained Women by Elliehausen, Christian J, Fairfield, William D, Minton, Dennis M, Nichol, Alex D, Rathmacher, John A, Pitchford, Lisa M, Paluska, Scott A, Allen, Jacob M, Konopka, Adam R

“…The age-related loss of skeletal muscle mass, quality, and strength can lead to the loss of independence later in life. Beta-hydroxy-beta-methylbutyrate (HMB),…”
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Subchronic (90-day) repeated dose oral toxicity study of 2-hydroxybenzylamine acetate in rabbit by Fuller, John C., Pitchford, Lisa M., Abumrad, Naji N., Rathmacher, John A.

“…2-hydroxybenzylamine (2-HOBA), a naturally occurring compound found in buckwheat, has potential for use as a nutrition supplement due to its ability to protect…”
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Health and ergogenic potential of oral adenosine-5′-triphosphate (ATP) supplementation by Jäger, Ralf, Purpura, Martin, Rathmacher, John A., Fuller, John C., Pitchford, Lisa M., Rossi, Fabricio E., Kerksick, Chad M.

“…[Display omitted] •Found in every cell, ATP affects every physiological process requiring energy.•ATP can communicate signals across cells once released into…”
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Genotoxicity assessment of calcium β-hydroxy-β-methylbutyrate by Pitchford, Lisa M., Fuller, John C., Rathmacher, John A.

“…β-Hydroxy-β-methylbutyrate (HMB) is a leucine metabolite available in calcium salt (CaHMB) and free acid forms as a sports nutrition ergogenic aid. HMB has…”
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In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate by Fuller, John C., Pitchford, Lisa M., Morrison, Ryan D., Daniels, J. Scott, Flynn, Charles R., Abumrad, Naji N., Oates, John A., Boutaud, Olivier, Rathmacher, John A.

“…2-hydroxybenzylamine (2-HOBA), a compound found in buckwheat, is a potent scavenger of reactive γ-ketoaldehydes, which are increased in diseases associated…”
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Acute and 28-day repeated dose toxicity evaluations of 2-hydroxybenzylamine acetate in mice and rats by Pitchford, Lisa M., Smith, Jodi D., Abumrad, Naji N., Rathmacher, John A., Fuller, John C.

“…2-hydroxybenzylamine (2-HOBA), a compound naturally found in buckwheat, has been shown to protect cells and tissues from the damaging effects of oxidative…”
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Effects of Reactiv “Maximum HMB” on Body Mass and Performance in Elite Male Rugby Players by Pitchford, Lisa M, Fuller, John C, Rathmacher, John A

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Small-Scale Randomized Controlled Trial to Explore the Impact of β-Hydroxy-β-Methylbutyrate Plus Vitamin D 3 on Skeletal Muscle Health in Middle Aged Women by Fairfield, William D, Minton, Dennis M, Elliehausen, Christian J, Nichol, Alexander D, Cook, Taylor L, Rathmacher, John A, Pitchford, Lisa M, Paluska, Scott A, Kuchnia, Adam J, Allen, Jacob M, Konopka, Adam R

“…β-Hydroxy-β-methylbutyrate (HMB), a leucine metabolite, can increase skeletal muscle size and function. However, HMB may be less effective at improving muscle…”
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