Search Results - "Pitcairn, Carol Ann"
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1
HDAC8 substrates: Histones and beyond
Published in Biopolymers (01-02-2013)“…The lysine deacetylase family of enzymes (HDACs) was first demonstrated to catalyze deacetylation of acetyllysine residues on histones. In subsequent years,…”
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Journal Article -
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An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8
Published in ACS chemical biology (17-10-2014)“…Despite being extensively characterized structurally and biochemically, the functional role of histone deacetylase 8 (HDAC8) has remained largely obscure due…”
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Journal Article -
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An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity
Published in Analytical biochemistry (01-07-2014)“…Histone deacetylases catalyze the hydrolysis of an acetyl group from post-translationally modified acetyl-lysine residues in a wide variety of essential…”
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Journal Article -
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The Specificity and Regulation of Human Histone Deacetylase 8
Published 01-01-2015“…Post-translational modifications (PTMs) of proteins increase the complexity of the proteome, alter protein function, and play important roles in cellular…”
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Dissertation