Absolute Configuration of Andrographolide and Its Proliferation of Osteoblast Cell Lines

Absolute Configuration of Andrographolide and Its Proliferation of Osteoblast Cell Lines

Andrographolide, C 20 H 30 O 5 , is a labdane diterpenoid which was isolated from the leave of Andrographis paniculata . Its crystal structure is determined by single crystal X-ray diffraction: monoclinic, sp. gr. P 2 1 , Z = 2. Absolute configuration is determined by the refinement of the Flack par...

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Bibliographic Details
Published in:Crystallography reports Vol. 63; no. 3; pp. 412 - 417
Main Authors: Chantrapromma, S., Boonnak, N., Pitakpornpreecha, T., Yordthong, T., Chidan Kumar, C. S., Fun, H. K.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-05-2018
Springer Nature B.V
Subjects:
60 APPLIED LIFE SCIENCES
Biocompatibility
Biotechnology
CELL PROLIFERATION
Configurations
CONNECTIVE TISSUE CELLS
Crystal structure
Crystallography and Scattering Methods
Diffraction
HYDROGEN
Hydrogen bonds
INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY
INTERACTIONS
Molecular chains
MOLECULES
MONOCLINIC LATTICES
MONOCRYSTALS
Physics
Physics and Astronomy
Single crystals
Structure of Organic Compounds
TWO-DIMENSIONAL SYSTEMS
X-RAY DIFFRACTION
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Summary:Andrographolide, C 20 H 30 O 5 , is a labdane diterpenoid which was isolated from the leave of Andrographis paniculata . Its crystal structure is determined by single crystal X-ray diffraction: monoclinic, sp. gr. P 2 1 , Z = 2. Absolute configuration is determined by the refinement of the Flack parameter to 0.21(19). In the crystal, molecules are linked by O–H···O hydrogen bonds and C–H···O interactions into two dimensional network parallel to the (001) plane. Its proliferation of osteoblast cell lines is reported.
ISSN:1063-7745
1562-689X
DOI:10.1134/S1063774518030069