Search Results - "Pissurlenkar, Raghuvir R.S"

Identification of novel potential anti-diabetic candidates targeting human pancreatic [alpha]-amylase and human [alpha]-glycosidase: an exhaustive structure-based screening by Maliwal, Deepika, Pissurlenkar, Raghuvir R.S, Telvekar, Vikas

“…Diabetes is a major health issue that has reached alarming levels, affecting nearly half a billion people worldwide. It is a serious and long-term medical…”
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Identification of novel potential anti-diabetic candidates targeting human pancreatic α-amylase and human α-glycosidase: an exhaustive structure-based screening by Maliwal, Deepika, Pissurlenkar, Raghuvir R.S, Telvekar, Vikas

“…Diabetes is a major health issue that has reached alarming levels, affecting nearly half a billion people worldwide. It is a serious and long-term medical…”
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Synthesis, in-silico studies, and biological evaluation of some novel 3-thiazolyl-indoles as CDK2–inhibitors by Gomha, Sobhi M., Zaki, Magdi E.A., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Ibrahim, Mohamed S., Fathalla, Maher, Hussein, Ahmed M.

“…The essential enzyme cyclin-dependent kinase 2 (CDK2) is a promising target for anticancer drug development due to its pivotal role in regulating the cell…”
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Extracting structural requirements for activity of GPR119 agonists: a hologram quantitative structure activity relationship (HQSAR) study by Ugarkar, Apoorva G, Ambre, Premlata K, Coutinho, Evans C, Nandan, Santosh, Pissurlenkar, Raghuvir R.S

“…GPR119 is a potential target for the treatment of diabetes mellitus. GPR119 agonists minimize the side-effects observed with sulphonyl ureas and glucagon-like…”
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Identification of new checkpoint kinase-1 (Chk1) inhibitors by docking, 3D-QSAR, and pharmacophore-modeling methods by Ambre, Premlata K, Pissurlenkar, Raghuvir R.S, Coutinho, Evans C, Iyer, Radhakrishnan P

“…Inhibition of checkpoint kinase-1 (Chk1) by small molecules is of great therapeutic interest in the field of oncology and for understanding cell-cycle…”
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Comprehensive computational study in the identification of novel potential cholesterol lowering agents targeting proprotein convertase subtilisin/kexin type 9 by Maliwal, Deepika, Pissurlenkar, Raghuvir R. S., Telvekar, Vikas

“…The enzymatic target proprotein convertase subtilisin/kexin type 9 (PCSK9) is critically involved in the regulation of the lipoprotein metabolism leading to…”
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Synthesis, biological screening and in silico studies of new N-phenyl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine derivatives as potential antifungal and antitubercular agents by Nandurkar, Yogesh, Bhoye, Manish R., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Chavan, Abhijit, Katade, Sushma, Mhaske, Pravin C.

“…A new series of N-aryl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine, (8a-x) have been synthesized by a cyclo-condensation reaction of…”
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Synthesis, antidiabetic activity and in silico studies of benzo[b]thiophene based small molecule α-amylase inhibitors by Joshi, Rupal J., Dholariya, Monil P., Chothani, Savankumar R., Chamakiya, Chirag A., Varu, Hardik L., Karmur, Manisha B., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Bapodra, Atul H., Patel, Anilkumar S., Kapuriya, Naval P.

“…•Benzo[b]thiophene based small molecule α-amylase inhibitors.•Significant antidiabetic activity with IC50 ranging from 5.37 to 29.89 μM.•Compound 3b more…”
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Solvent-free synthesis, biological evaluation and in silico studies of novel 2-amino-7-(bis(2-hydroxyethyl)amino)-4H-chromene-3-carbonitrile derivatives as potential a-amylase inhibitors by Chothani, Savankumar R., Dholariya, Monil P., Joshi, Rupal J., Chamakiya, Chirag A., Maliwal, Deepika, Pissurlenkar, Raghuvir R.S., Patel, Anilkumar S., Bhalodia, Jasmin J., Ambasana, Mrunal A., Patel, Rashmiben B., Bapodra, Atul H., Kapuriya, Naval P.

“…•Solvent free multicomponent protocol for novel 2-amino-4H-chromene derivatives.•Structure determination by IR, mass, 1H & 13C NMR spectroscopy and elemental…”
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Curcumin and kaempferol prevent lysozyme fibril formation by modulating aggregation kinetic parameters by Borana, Mohanish S., Mishra, Pushpa, Pissurlenkar, Raghuvir R.S., Hosur, Ramakrishna V., Ahmad, Basir

“…Interaction of small molecule inhibitors with protein aggregates has been studied extensively, but how these inhibitors modulate aggregation kinetic parameters…”
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The reorganization of conformations, stability and aggregation of serum albumin isomers through the interaction of glycopeptide antibiotic teicoplanin: A thermodynamic and spectroscopy study by Muthu, Shivani A., Jadav, Helly Chetan, Srivastava, Sadhavi, Pissurlenkar, Raghuvir R.S., Ahmad, Basir

“…The drugs-protein binding study is of growing importance for drug-repurposing against amyloidosis. In this work, we study the binding of teicoplanin (TPN), a…”
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New thiazolyl-isoxazole derivatives as potential anti-infective agents: design, synthesis, in vitro and in silico antimicrobial efficacy by Bhoye, Manish R, Shinde, Abhijit, Shaikh, Abdul Latif N, Shisode, Vilas, Chavan, Abhijit, Maliwal, Deepika, Pissurlenkar, Raghuvir R S, Mhaske, Pravin C

“…Antimicrobial resistance threatens the efficacious prevention and treatment of infectious diseases caused by microorganisms. To combat microbial infections,…”
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An Efficient Synthesis, Antimicrobial Evaluation and In Silico Studies of 1,2,3‐Triazolyl‐isoxazolyl‐ethanol Derivatives by Bhoye, Manish R., Latif Shaikh, Abdul, Walunj, Yogesh, Pissurlenkar, Raghuvir R. S., Chavan, Abhijit, Mhaske, Pravin C.

“…A series of 2‐(1‐substituted benzyl‐1H‐1,2,3‐triazol‐4‐yl)‐1‐(5‐arylisoxazol‐3‐yl)ethanol (8 a–p) have been designed and efficiently synthesized. The structure…”
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Physical basis for the ofloxacin-induced acceleration of lysozyme aggregation and polymorphism in amyloid fibrils by Muthu, Shivani A., Mothi, Nivin, Shiriskar, Sonali M., Pissurlenkar, Raghuvir R.S., Kumar, Anil, Ahmad, Basir

“…Aggregation of globular proteins is an intractable problem which generally originates from partially folded structures. The partially folded structures first…”
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The cocrystal of 3-((4-(3-isocyanobenzyl) piperazine-1-yl) methyl) benzonitrile with 5-hydroxy isophthalic acid prevents protofibril formation of serum albumin by Shabbir, Sadiya, Muslim, Mohd, Muthu, Shivani A., Pissurlenkar, Raghuvir R. S., Fatima, Shaista, Ali, Arif, Ahmad, Aiman, Ahmad, Musheer, Ahmad, Basir

“…The formation of amyloid-like fibrils is a central problem in biophysical chemistry and medicine. Fibril formation and their deposition in various tissues and…”
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Synthesis and studies of covalently linked meso-furyl boron-dipyrromethene-ferrocene conjugates by Khan, Tamanna K., Pissurlenkar, Raghuvir R.S., Shaikh, Mushtaque S., Ravikanth, M.

“…Four meso-furyl BODIPY-ferrocene conjugates 1– 4 in which one or more ferrocene groups were connected directly to BODIPY core or meso-furyl group were…”
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Synthesis, anticancer evaluation and in silico studies of novel N‐substituted arylidenethiazolidine‐2,4‐dione derivatives as adenosine monophosphate‐activated protein kinase activators by Chothani, Savankumar R., Chamakiya, Chirag A., Joshi, Rupal J., Karmur, Manisha B., Karmur, Sheetal B., Varu, Hardik L., Pissurlenkar, Raghuvir R. S., Patel, Anilkumar S., Kapuriya, Naval P.

“…Design and development of AMP‐activated protein kinase (AMPK) activator emerged as a potential therapeutic approach for various types of cancers. In this…”
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Effects of hesperidin, a flavanone glycoside interaction on the conformation, stability, and aggregation of lysozyme: multispectroscopic and molecular dynamic simulation studies? by Ratnaparkhi, Aditi, Muthu, Shivani A., Shiriskar, Sonali M., Pissurlenkar, Raghuvir R.S., Choudhary, Sinjan, Ahmad, Basir

“…Hesperidin (HESP), a flavanone glycoside, shows high antioxidant properties and posses ability to go through the blood-brain barrier. Therefore, it could be a…”
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Design, Synthesis and Antidiabetic Activity of Biphenylcarbonitrile‐Thiazolidinedione Conjugates as Potential α‐Amylase Inhibitors by Rathod, Chirag H., Nariya, Pankajkumar B., Maliwal, Deepika, Pissurlenkar, Raghuvir RS, Kapuriya, Naval P., Patel, Anilkumar S.

“…The α‐amylase inhibition has been considered as an effective therapeutic approach against chronic Type 2 Diabetes mellitus (DM). In the present study, a series…”
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Effects of 2-amino-8-hydroxyquinoline interaction on the conformation of physiological isomers of human serum albumin by Shiriskar, Sonali M., Agarwal, Neeraj, Pissurlenkar, Raghuvir R. S., Ahmad, Basir

“…The methods of synthetic chemistry create small molecules rapidly for screening, and ligand–protein interaction studies provide information on how a potential…”
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