Search Results - "Piskunova, Tatiana S."

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice by Anisimov, Vladimir N., Zabezhinski, Mark A., Popovich, Irina G., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Margarita L., Yurova, Maria N., Rosenfeld, Svetlana V., Blagosklonny, Mikhail V

“…The nutrient-sensing TO R (target of rapamycin) pathway is involved in cellular and organismal aging. Rapamycin, an inhibitor of TO R, extends lifespan in…”
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Metformin slows down aging and extends life span of female SHR mice by Anisimov, Vladimir N., Berstein, Lev M., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Zabezhinski, Mark A., Tyndyk, Margarita L., Yurova, Maria V., Kovalenko, Irina G., Poroshina, Tatiana E., Semenchenko, Anna V.

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice by Anisimov, Vladimir N, Berstein, Lev M, Popovich, Irina G, Zabezhinski, Mark A, Egormin, Peter A, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Kovalenko, Irina G, Poroshina, Tatiana E

“…Hyperglycemia and hyperinsulinemia accelerate both aging and cancer. Antidiabetic biguanides such as metformin decrease glucose, insulin and IGF-1 level…”
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Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo by Anisimov, Vladimir N., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Tyndyk, Margarita L., Yurova, Maria N., Zabezhinski, Mark A., Anikin, Ivan V., Karkach, Arseniy S., Romanyukha, Alexey A.

“…Population studies have shown that treatment with the antidiabetic biguanide metformin significantly reduced cancer risk. In our animal studies, metformin…”
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Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice by Anisimov, Vladimir N., Berstein, Lev M., Egormin, Peter A., Piskunova, Tatiana S., Popovich, Irina G., Zabezhinski, Mark A., Kovalenko, Irina G., Poroshina, Tatiana E., Semenchenko, Anna V., Provinciali, Mauro, Re, Francesca, Franceschi, Claudio

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer…”
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Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N, Antoch, Marina P, Blagosklonny, Mikhail V

“…Aging is associated with obesity and cancer. Calorie restriction both slows down aging and delays cancer. Evidence has emerged that the nutrient-sensing…”
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Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice by Anisimov, Vladimir N, Piskunova, Tatiana S, Popovich, Irina G, Zabezhinski, Mark A, Tyndyk, Margarita L, Egormin, Peter A, Yurova, Maria V, Rosenfeld, Svetlana V, Semenchenko, Anna V, Kovalenko, Irina G, Poroshina, Tatiana E, Berstein, Lev M

“…Studies in mammals have led to the suggestion that hyperglycemia and hyperinsulinemia are important factors both in aging and in the development of cancer. It…”
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Exposure to light at night accelerates aging and spontaneous uterine carcinogenesis in female 129/Sv mice by Popovich, Irina G., Zabezhinski, Mark A., Panchenko, Andrei V., Piskunova, Tatiana S., Semenchenko, Anna V., Tyndyk, Maragriata L., Yurova, Maria N., Anisimov, Vladimir N.

“…The effect of the constant illumination on the development of spontaneous tumors in female 129/Sv mice was investigated. Forty-six female 129/Sv mice starting…”
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Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice by Piskunova, Tatiana S., Yurova, Maria N., Ovsyannikov, Anton I., Semenchenko, Anna V., Zabezhinski, Mark A., Popovich, Irina G., Wang, Zhao-Qi, Anisimov, Vladimir N.

“…Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death,…”
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Rodent models for the preclinical evaluation of drugs suitable for pharmacological intervention in aging by Anisimov, Vladimir N, Zabezhinski, Mark A, Popovich, Irina G, Pliss, Gennady B, Bespalov, Vladimir G, Alexandrov, Valeri A, Stukov, Alexander N, Anikin, Ivan V, Alimova, Irina N, Egormin, Peter А, Panchenko, Andrey V, Piskunova, Tatiana S, Semenchenko, Anna V, Tyndyk, Margarita L, Yurova, Maria N

“…There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span,…”
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Body weight is not always a good predictor of longevity in mice by Anisimov, Vladimir N, Arbeev, Konstantin G, Popovich, Irina G, Zabezhinksi, Mark A, Rosenfeld, Svetlana V, Piskunova, Tatiana S, Arbeeva, Lyubov S, Semenchenko, Anna V, Yashin, Anatoli I

“…There have been some observations that low body weight and a low level of some hormones (e.g. IGF-1) during the first half of life are predictors of longer…”
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Rapamycin Extends Maximal Lifespan in Cancer-Prone Mice by ANISIMOV, Vladimir N, ZABEZHINSKI, Mark A, POPOVICH, Irina G, PISKUNOVA, Tatiana S, SEMENCHENKO, Anna V, TYNDYK, Margarita L, YUROVA, Maria N, ANTOCH, Marina P, BLAGOSKLONNY, Mikhail V

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