Search Results - "Pisetsky, DS"

Tumor Necrosis Factor Blockers in Rheumatoid Arthritis by Pisetsky, David S

“…For patients with rheumatoid arthritis, a new era in treatment has begun. This optimistic view, shared widely by rheumatologists, reflects the introduction in…”
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HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease by Harris, Helena Erlandsson, Andersson, Ulf, Pisetsky, David S.

“…HMGB1 is a non-histone nuclear protein that can serve as an alarmin to promote inflammation. In this Review, the authors present an overview of the structure…”
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Microparticles as autoantigens in systemic lupus erythematosus by Mobarrez, Fariborz, Svenungsson, Elisabet, Pisetsky, David S.

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antibodies to components of the cell nucleus…”
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Microparticles in the blood of patients with SLE: Size, content of mitochondria and role in circulating immune complexes by Mobarrez, Fariborz, Fuzzi, Enrico, Gunnarsson, Iva, Larsson, Anders, Eketjäll, Susanna, Pisetsky, David S., Svenungsson, Elisabet

“…Microparticles (MPs) are small extracellular vesicles released from apoptotic or activated cells through a blebbing process. MPs express surface molecules from…”
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The expression of antibodies to Z-DNA in the blood of patients with systemic lupus erythematosus: Relationship to autoantibodies to B-DNA by Spencer, Diane M., Svenungsson, Elisabet, Gunnarsson, Iva, Caricchio, Roberto, Pisetsky, David S.

“…To explore the antibody response to Z-DNA, a DNA conformation with a zig-zag structure, blood of patients with systemic lupus erythematosus (SLE) and otherwise…”
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Toll-like receptors in the pathogenesis of human disease by Cook, Donald N, Pisetsky, David S, Schwartz, David A

“…Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases…”
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Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations by Mobarrez, Fariborz, Vikerfors, Anna, Gustafsson, Johanna T., Gunnarsson, Iva, Zickert, Agneta, Larsson, Anders, Pisetsky, David S., Wallén, Håkan, Svenungsson, Elisabet

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by circulating autoantibodies and the formation of immune complexes. In…”
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The binding of SLE autoantibodies to mitochondria by Pisetsky, David S., Spencer, Diane M., Mobarrez, Fariborz, Fuzzi, Enrico, Gunnarsson, Iva, Svenungsson, Elisabet

“…Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by immune complexes. Because these complexes contain mitochondrial…”
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The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers by Mobarrez, Fariborz, Antoniewicz, Lukasz, Bosson, Jenny A, Kuhl, Jeanette, Pisetsky, David S, Lundbäck, Magnus

“…Cigarette smoking, both active and passive, is one of the leading causes of morbidity and mortality in cardiovascular disease. To assess the impact of brief…”
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High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease by Pisetsky, David S, Erlandsson-Harris, Helena, Andersson, Ulf

“…High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription…”
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Immunostimulatory DNA: A clear and present danger by Pisetsky, David S

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Microparticles as autoantigens in human and murine lupus by Ullal, A, Pisetsky, DS

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Effect of Lipopolysaccharide Administration on the Number, Phenotype and Content of Nuclear Molecules in Blood Microparticles of Normal Human Subjects by Soop, A., Hållström, L., Frostell, C., Wallén, H., Mobarrez, F., Pisetsky, D. S.

“…Microparticles (MPs) are small membrane‐bound vesicles that arise from activated and dying cells and promote inflammation and thrombosis. To characterize the…”
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CD40L expression in plasma of volunteers following LPS administration: A comparison between assay of CD40L on platelet microvesicles and soluble CD40L by Mobarrez, Fariborz, Sjövik, Carolina, Soop, Anne, Hållström, Lars, Frostell, Claes, Pisetsky, David S., Wallén, Håkan

“…Abstract CD40 ligand (CD40L) is a transmembrane protein that is mainly expressed on activated T cells and platelets. This protein, however, may also be shed…”
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The expression of microvesicles in the blood of patients with Graves' disease and its relationship to treatment by Mobarrez, Fariborz, Abraham-Nordling, Mirna, Aguilera-Gatica, Katherina, Friberg, Inger, Antovic, Aleksandra, Pisetsky, David S., Jörneskog, Gun, Wallen, Håkan

“…Summary Objective Graves' disease (GD) is an autoimmune disease characterized by the presence of circulating autoantibodies against thyroid‐stimulating hormone…”
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Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies by Grundtman, Cecilia, Bruton, Joseph, Yamada, Takashi, Östberg, Therese, Pisetsky, David S, Harris, Helena Erlandsson, Andersson, Ulf, Lundberg, Ingrid E, Westerblad, Håkan

“…Idiopathic inflammatory myopathies (IIMs) are heterogeneous rheumatic disorders of unknown cause characterized by muscle weakness, inflammatory cell…”
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A Holistic Approach to Pain Management in the Rheumatic Diseases by Golenbiewski, Jon T., Pisetsky, David S.

“…Purpose of the review Pain is the most common symptom of patients with rheumatic disease, and its characteristics can be used to diagnose disease, assess…”
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The Induction of Matrix Metalloproteinase and Cytokine Expression in Synovial Fibroblasts Stimulated with Immune Cell Microparticles by Jörg H. W. Distler, Jüngel, Astrid, Huber, Lars C., Seemayer, Christian A., Reich, Charles F., Gay, Renate E., Michel, Beat A., Fontana, Adriano, Gay, Steffen, Pisetsky, David S., Distler, Oliver, Dinarello, Charles A.

“…Rheumatoid arthritis is a chronic inflammatory disease characterized by destruction of cartilage and bone that is mediated by synovial fibroblasts. To…”
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The role of biomechanics and inflammation in cartilage injury and repair by Guilak, Farshid, Fermor, Beverley, Keefe, Francis J, Kraus, Virginia B, Olson, Steven A, Pisetsky, David S, Setton, Lori A, Weinberg, J Brice

“…Osteoarthritis is a painful and debilitating disease characterized by progressive degenerative changes in the articular cartilage and other joint tissues…”
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The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells by Choi, Jin‐Jung, Reich, Charles F., Pisetsky, David S.

“…Summary Cell death is a ubiquitous process that occurs by apoptosis or necrosis depending on the triggering event. While apoptotic and necrotic cells differ…”
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