Search Results - "Piser, Timothy"

Linking the cytokine and neurocircuitry hypotheses of depression: A translational framework for discovery and development of novel anti-depressants by Piser, Timothy M

“…Abstract Recent studies suggest a model of depression that links the cytokine hypothesis from the field of psychoneuroimmunology with the neurocircuitry…”
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Adjunctive Lanicemine (AZD6765) in Patients with Major Depressive Disorder and History of Inadequate Response to Antidepressants: A Randomized, Placebo-Controlled Study by Sanacora, Gerard, Johnson, Michael R, Khan, Arif, Atkinson, Sarah D, Riesenberg, Robert R, Schronen, Juan P, Burke, Michael A, Zajecka, John M, Barra, Luis, Su, Hong-Lin, Posener, Joel A, Bui, Khanh H, Quirk, Michael C, Piser, Timothy M, Mathew, Sanjay J, Pathak, Sanjeev

“…The objective of this study was to investigate the efficacy and safety of adjunctive lanicemine (NMDA channel blocker) in the treatment of major depressive…”
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Assessment of gait and balance impairment in people with spinocerebellar ataxia using wearable sensors by Zhou, He, Nguyen, Hung, Enriquez, Ana, Morsy, Louie, Curtis, Michael, Piser, Timothy, Kenney, Christopher, Stephen, Christopher D., Gupta, Anoopum S., Schmahmann, Jeremy D., Vaziri, Ashkan

“…Objective To explore the use of wearable sensors for objective measurement of motor impairment in spinocerebellar ataxia (SCA) patients during clinical…”
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3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors Protect Cortical Neurons from Excitotoxicity by Zacco, Anna, Togo, James, Spence, Katherine, Ellis, Amanda, Lloyd, Darlene, Furlong, Steve, Piser, Timothy

“…3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, or statins, reduce the incidence of strokes and reduce infarct volume after cerebral ischemia in…”
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Identification of short-acting κ-opioid receptor antagonists with anxiolytic-like activity by Peters, Matthew F., Zacco, Anna, Gordon, John, Maciag, Carla M., Litwin, Linda C., Thompson, Carolann, Schroeder, Patricia, Sygowski, Linda A., Piser, Timothy M., Brugel, Todd A.

“…The κ-opioid receptor plays a central role in mediating the response to stressful life events. Inhibiting κ-opioid receptor signaling is proposed as a…”
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Cannabinoid Receptor Agonists Inhibit Glutamatergic Synaptic Transmission in Rat Hippocampal Cultures by Shen, Maoxing, Piser, Timothy M, Seybold, Virginia S, Thayer, Stanley A

“…Activation of cannabinoid receptors inhibits voltage-gated Ca2+ channels and activates K+ channels, reminiscent of other G-protein-coupled signaling pathways…”
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Immediate and Sustained Improvements in Working Memory After Selective Stimulation of α7 Nicotinic Acetylcholine Receptors by Castner, Stacy A, Smagin, Gennady N, Piser, Timothy M, Wang, Yi, Smith, Jeffrey S, Christian, Edward P, Mrzljak, Ladislav, Williams, Graham V

“…Background Nicotine improves cognition in humans and animal models of neuropsychiatric disorders. Here, we sought to establish whether selective stimulation of…”
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In vitro metabolism of α7 neuronal nicotinic receptor agonist AZD0328 and enzyme identification for its N-oxide metabolite by Zhou, Diansong, Zhang, Minli, Ye, Xiaomei, Gu, Chungang, Piser, Timothy M., Lanoue, Bernard A., Schock, Sara A., Cheng, Yi-Fang, Grimm, Scott W.

“…AZD0328 was pharmacologically characterized as a α7 neuronal nicotinic receptor agonist intended for treatment of Alzheimer′s disease. In vitro AZD0328 cross…”
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Purification, characterization and catalytic properties of human sterol 8-isomerase by Nes, W David, Zhou, Wenxu, Dennis, Allen L, Li, Haoxia, Jia, Zhonghua, Keith, Richard A, Piser, Timothy M, Furlong, Stephen T

“…CHO 2, encoding human sterol 8-isomerase (hSI), was introduced into plasmids pYX213 or pET23a. The resulting native protein was overexpressed in erg 2 yeast…”
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Microplate gel-filtration method for radioligand-binding assays by Liu, Jianwei, Zacco, Anna, Piser, Timothy M, Scott, Clay W

“…A thin-layer gel-filtration chromatographic method has been developed in a 96-well format to separate free and protein-bound ligand in radioligand-binding…”
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Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays by Stoiljkovic, Milan, Leventhal, Liza, Chen, Angela, Chen, Ting, Driscoll, Rachelle, Flood, Dorothy, Hodgdon, Hilliary, Hurst, Raymond, Nagy, David, Piser, Timothy, Tang, Cuyue, Townsend, Matthew, Tu, Zhiming, Bertrand, Daniel, Koenig, Gerhard, Hajós, Mihaly

“…[Display omitted] Pharmacological activation of α7 nicotinic acetylcholine receptors (α7 nAChRs) may improve cognition in schizophrenia and Alzheimer’s…”
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Differential Coupling of M1 Muscarinic and α7 Nicotinic Receptors to Inhibition of Pemphigus Acantholysis by Chernyavsky, Alex I., Arredondo, Juan, Piser, Timothy, Karlsson, Evert, Grando, Sergei A.

“…The mechanisms mediating and regulating assembly and disassembly of intercellular junctions is a subject of intensive research. The IgG autoantibodies produced…”
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Differential Coupling of M1 Muscarinic and α7 Nicotinic Receptors to Inhibition of Pemphigus Acantholysis by Alex I. Chernyavsky, Juan Arredondo, Timothy Piser, Evert Karlsson, Sergei A. Grando

“…The mechanisms mediating and regulating assembly and disassembly of intercellular junctions is a subject of intensive research. The IgG autoantibodies produced…”
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Differential Coupling of M sub(1) Muscarinic and alpha 7 Nicotinic Receptors to Inhibition of Pemphigus Acantholysis by Chernyavsky, Alex I, Arredondo, Juan, Piser, Timothy, Karlsson, Evert, Grando, Sergei A

“…The mechanisms mediating and regulating assembly and disassembly of intercellular junctions is a subject of intensive research. The IgG autoantibodies produced…”
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Cloning and Characterization of Two K+ Inward Rectifier (Kir) 1.1 Potassium Channel Homologs from Human Kidney (Kir1.2 and Kir1.3) by Shuck, M E, Piser, T M, Bock, J H, Slightom, J L, Lee, K S, Bienkowski, M J

“…The DNA sequence encoding the rat brain inward rectifier-10 K + channel was amplified from rat brain RNA using reverse transcription-polymerase chain reaction…”
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Differential coupling of M1 muscarinic and alpha7 nicotinic receptors to inhibition of pemphigus acantholysis by Chernyavsky, Alex I, Arredondo, Juan, Piser, Timothy, Karlsson, Evert, Grando, Sergei A

“…The mechanisms mediating and regulating assembly and disassembly of intercellular junctions is a subject of intensive research. The IgG autoantibodies produced…”
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HIV-1 envelope protein evokes intracellular calcium oscillations in rat hippocampal neurons by Lo, T M, Fallert, C J, Piser, T M, Thayer, S A

“…Treatment of single rat hippocampal neurons with 200 pM recombinant HIV-1 envelope glycoprotein, gp120, resulted in large increases in the intracellular free…”
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Pharmacologic modulation of the voltage-gated calcium channels coupled to glutamatergic synaptic transmission by Piser, Timothy Martin

“…Neurotransmitter release is coupled to electrical depolarization by influx of Ca$\sp{2+}$ through voltage-gated channels. I characterized inhibition of…”
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Complete and reversible block by ω-grammotoxin SIA of glutamatergic synaptic transmission between cultured rat hippocampal neurons by Piser, Timothy M., Lampe, Richard A., Keith, Richard A., Thayer, Stanley A.

“…ω-Grammotoxin SIA (ω-GsTx SIA), a peptide isolated from tarantula venom, inhibits synaptosomal Ca 2+ influx and neurotransmitter release, and blocks N-, P-,…”
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Effects of stimulus intensity on the inhibition by omega-conotoxin GVIA and neomycin of K(+_-evoked [3H]norepinephrine release from hippocampal brain slices and synaptosomal calcium influx by Keith, R A, Horn, M B, Piser, T M, Mangano, T J

“…The effects of various K+ concentrations on the inhibition of [3H]norepinephrine release from rat hippocampal brain slices and evoked synaptosomal 45Ca2+…”
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