Search Results - "Piscitelli, Chayne L."

Unlocking the molecular secrets of sodium-coupled transporters by Krishnamurthy, Harini, Piscitelli, Chayne L, Gouaux, Eric

“…Transmembrane sodium-ion gradients provide energy that can be harnessed by 'secondary transporters' to drive the translocation of solute molecules into a cell…”
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Competitive Inhibitor Traps LeuT in an Open-to-Out Conformation by Singh, Satinder K, Piscitelli, Chayne L, Yamashita, Atsuko, Gouaux, Eric

“…Secondary transporters are workhorses of cellular membranes, catalyzing the movement of small molecules and ions across the bilayer and coupling substrate…”
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Neurotransmitter/sodium symporter orthologue LeuT has a single high-affinity substrate site by Gouaux, Eric, Piscitelli, Chayne L, Krishnamurthy, Harini

“…Neurotransmitter/sodium symporters (NSSs) couple the uptake of neurotransmitter with one or more sodium ions, removing neurotransmitter from the synaptic…”
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A Molecular Pharmacologist's Guide to G Protein-Coupled Receptor Crystallography by Piscitelli, Chayne L, Kean, James, de Graaf, Chris, Deupi, Xavier

“…G protein-coupled receptor (GPCR) structural biology has progressed dramatically in the last decade. There are now over 120 GPCR crystal structures deposited…”
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Insights into transport mechanism from LeuT engineered to transport tryptophan by Piscitelli, Chayne L, Gouaux, Eric

“…LeuT is a bacterial homologue of the neurotransmitter:sodium symporter (NSS) family and, being the only NSS member to have been structurally characterized by…”
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Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling by Thieltges, Katherine M., Avramovic, Dragana, Piscitelli, Chayne L., Markovic-Mueller, Sandra, Binz, Hans Kaspar, Ballmer-Hofer, Kurt

“…Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The…”
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Equilibrium between Metarhodopsin-I and Metarhodopsin-II Is Dependent on the Conformation of the Third Cytoplasmic Loop by Piscitelli, Chayne L., Angel, Thomas E., Bailey, Brian W., Hargrave, Paul, Dratz, Edward A., Lawrence, C. Martin

“…Rhodopsin is a G-protein-coupled receptor (GPCR) that is the light detector in the rod cells of the eye. Rhodopsin is the best understood member of the large…”
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1372 TriTCE Co-Stim: a novel trispecific T cell engager platform, with integrated CD28 costimulation, engineered to widen the therapeutic window for treatment of poorly infiltrated tumors by Newhook, Lisa, Bhojane, Purva, Repenning, Peter, Lau, Desmond, Escalante, Nichole, Escanda, Diego Perez, Shao, Polly, Poffenberger, Maya, Robinson, Alec, Patel, Kesha, Livernois, Alexandra, Piscitelli, Chayne L, Afacan, Nicole, Kreudenstein, Thomas Spreter von, Weisser, Nina

“…BackgroundBispecific T cell engagers (TCEs) have shown clinical benefit in treating hematological cancers, but limited success in solid tumors. Overcoming the…”
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Structure of β-adrenergic receptors by Brueckner, Florian, Piscitelli, Chayne L, Tsai, Ching-Ju, Standfuss, Jörg, Deupi, Xavier, Schertler, Gebhard F X

“…β-Adrenergic receptors (βARs) control key physiological functions by transducing signals encoded in catecholamine hormones and neurotransmitters to activate…”
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Insights into transport mechanism from LeuT engineered to transport tryptophan: Insights into transport mechanism by Piscitelli, Chayne L, Gouaux, Eric

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Abstract 6716: DLL3 TriTCE Co-Stim: A next generation trispecific T cell engager with integrated CD28 costimulation for the treatment of DLL3-expressing cancers by Repenning, Peter, Lau, Desmond, Hernaez, Diana C., Robinson, Alec, Escanda, Diego P., Rocha, Mariana, Moreno, Begonia S., Zhang, John, Shao, Polly, Escalante, Nichole, Newhook, Lisa, Bhojane, Purva, Piscitelli, Chayne L., Moore, Paul A., Von Kreudenstein, Thomas Spreter, Weisser, Nina E.

“…Abstract Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with a poor prognosis and high unmet medical need. Current standards of care,…”
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Abstract 6719: TriTCE Co-Stim: A next generation trispecific T cell engager platform with integrated CD28 costimulation, engineered to improve responses in the treatment of solid tumors by Newhook, Lisa, Bhojane, Purva, Stahl, Kurt, Escalante, Nichole E., Repenning, Peter, Escanda, Diego Perez, Shao, Polly, Poffenberger, Maya C., Robinson, Alec, Patel, Kesha, Livernois, Alexandra, Piscitelli, Chayne L., Afacan, Nicole, Moore, Paul A., Weisser, Nina E., von Kreudenstein, Thomas Spreter

“…Abstract Bispecific T cell engagers (TCEs) have exhibited clinical successes in the treatment of hematological cancers, while treatment of solid tumors remains…”
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Abstract 2982: TriTCE CPI, next generation trispecific T cell engagers with integrated checkpoint inhibition (CPI) for the treatment of solid tumors by Poffenberger, Maya C., Verstraete, Meghan M., Von Rossum, Anna, Zwierzchowski, Patricia, Zago, Matteo, Luu, Veronica, Arrafi, Sifa, Cao, Siran, Pratap, Harsh, Piscitelli, Chayne L., Weisser, Nina E., von Kreudenstein, Thomas Spreter

“…Abstract CD3-bispecific T cell engager (TCE) therapies have exhibited clinical utility against hematological malignancies, but successes in solid tumor…”
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Abstract 5121: TriTCE Co-stim, next generation costimulatory trispecific T cell engagers for the treatment of solid tumors by Newhook, Lisa, Bhojane, Purva P., Repenning, Peter W., Escanda, Diego Perez, Escalante, Nichole K., Zwierzchowski, Patricia, Robinson, Alec, Clifford, Lauren, Pratap, Harsh, Douda, David N., Piscitelli, Chayne L., Afacan, Nicole J., von Kreudenstein, Thomas Spreter, Weisser, Nina E.

“…Abstract Bispecific T cell engager (TCE) therapies have exhibited clinical utility against hematological cancers, but limited success in solid tumors…”
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Abstract 2658: ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload by Madera, Laurence, Rojas, Andrea Hernández, Colombo, Raffaele, Wu, Alex, Piscitelli, Chayne L., Urosev, Dunja, Bissessur, Allysha, Cheng, Chi Wing, Duan, Renee, Kim, Catrina, Yin, Kevin, Fung, Vincent, Wu, Kaylee, Cheung, Winnie, Alonzo, Diego A., Petersen, Mark E., Barnscher, Stuart D., Rich, Jamie R.

“…Abstract Background: Glypican-3 (GPC3) is a cell-surface oncofetal glycoprotein frequently expressed in hepatocellular carcinoma (HCC) with minimal presence in…”
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Unlocking the molecular secrets of sodium-coupled transporters : Membrane protein biophysics by KRISHNAMURTHY, Harini, PISCITELLI, Chayne L, GOUAUX, Eric

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