Search Results - "Pisaneschi, Federica"

Development and Validation of a PET/SPECT Radiopharmaceutical in Oncology by Pisaneschi, Federica, Viola, Nerissa T.

“…In oncology, biomarker research aimed to provide insights on cancer biology via positron emission tomography (PET) and single photon emission tomography…”
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RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging by Sutton, Margie N., Gammon, Seth T., Muzzioli, Riccardo, Pisaneschi, Federica, Radaram, Bhasker, Yang, Ping, Piwnica-Worms, David

“…Purpose Macropinocytosis serves as a highly conserved endocytotic process that has recently been shown as a critical mechanism by which RAS-transformed cells…”
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PET/MR Imaging of a Lung Metastasis Model of Clear Cell Renal Cell Carcinoma with (2S,4R)-4-[18F]Fluoroglutamine by Pollard, Alyssa C., Paolillo, Vincenzo, Radaram, Bhasker, Qureshy, Sarah, Li, Li, Maity, Tapati, Wang, Lei, Uddin, Md. Nasir, Wood, Christopher G., Karam, Jose A., Pagel, Mark D., Piwnica-Worms, David, Millward, Steven W., Fowlkes, Natalie Wall, Norton, William, Engel, Brian J., Pisaneschi, Federica, Zacharias, Niki M.

“…Purpose Metabolic reprogramming plays an important role in the tumorigenesis of clear cell renal cell carcinoma (ccRCC). Currently, positron emission…”
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Development of a Potential Gallium-68-Labelled Radiotracer Based on DOTA-Curcumin for Colon-Rectal Carcinoma: From Synthesis to In Vivo Studies by Orteca, Giulia, Pisaneschi, Federica, Rubagotti, Sara, Liu, Tracy W, Biagiotti, Giacomo, Piwnica-Worms, David, Iori, Michele, Capponi, Pier Cesare, Ferrari, Erika, Asti, Mattia

“…Colorectal cancer is the third most commonly occurring cancer in men and the second most commonly occurring cancer in women worldwide. We have recently…”
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An enolase inhibitor for the targeted treatment of ENO1-deleted cancers by Lin, Yu-Hsi, Satani, Nikunj, Hammoudi, Naima, Yan, Victoria C., Barekatain, Yasaman, Khadka, Sunada, Ackroyd, Jeffrey J., Georgiou, Dimitra K., Pham, Cong-Dat, Arthur, Kenisha, Maxwell, David, Peng, Zhenghong, Leonard, Paul G., Czako, Barbara, Pisaneschi, Federica, Mandal, Pijus, Sun, Yuting, Zielinski, Rafal, Pando, Susana Castro, Wang, Xiaobo, Tran, Theresa, Xu, Quanyu, Wu, Qi, Jiang, Yongying, Kang, Zhijun, Asara, John M., Priebe, Waldemar, Bornmann, William, Marszalek, Joseph R., DePinho, Ronald A., Muller, Florian L.

“…Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We have previously identified a subset of cancers harbouring homozygous…”
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Radiometal-Based PET/MRI Contrast Agents for Sensing Tumor Extracellular pH by Pollard, Alyssa C, de la Cerda, Jorge, Schuler, F William, Pollard, Tyler R, Kotrotsou, Aikaterini, Pisaneschi, Federica, Pagel, Mark D

“…Acidosis is a useful biomarker for tumor diagnoses and for evaluating early response to anti-cancer treatments. Despite these useful applications, there are…”
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The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues by Pisaneschi, Federica, Yu-Hsi, Lin, Leonard, Paul G, Satani, Nikunj, Yan, Victoria C, Hammoudi, Naima, Raghavan, Sudhir, Link, Todd M, Georgiou, Dimitra K, Czako, Barbara, Muller, Florian L

“…We recently reported that SF2312 ((1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid), a phosphonate antibiotic with a previously unknown mode of action, is a…”
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Apoptosis Detection in Retinal Ganglion Cells Using Quantitative Changes in Multichannel Fluorescence Colocalization by Qiu, Xudong, Gammon, Seth T, Johnson, James R, Pisaneschi, Federica, Millward, Steven W, Barnett, Edward M, Piwnica-Worms, David

“…KcapTR488 is a dual-fluorophore peptide sensor for the real-time reporting of programmed cell death by fluorescence imaging. KcapTR488 contains a nuclear…”
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Positron Emission Tomographic Imaging of CXCR4 in Cancer: Challenges and Promises by George, Guillaume Pierre Charles, Pisaneschi, Federica, Nguyen, Quang-Dé, Aboagye, Eric Ofori

“…Molecular imaging is an attractive platform for noninvasive detection and assessment of cancer. In recent years, the targeted imaging of the C–X–C chemokine…”
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Identification of ABC Transporter Interaction of a Novel Cyanoquinoline Radiotracer and Implications for Tumour Imaging by Positron Emission Tomography by Slade, Rozanna L, Pisaneschi, Federica, Nguyen, Quang-De, Smith, Graham, Carroll, Laurence, Beckley, Alice, Kaliszczak, Maciej A, Aboagye, Eric O

“…The epidermal growth factor receptor (EGFR) is overexpressed in many cancers including lung, ovarian, breast, head and neck and brain. Mutation of this…”
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Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [ 18 F]FAZA PET In Vivo by Gammon, Seth T, Pisaneschi, Federica, Bandi, Madhavi L, Smith, Melinda G, Sun, Yuting, Rao, Yi, Muller, Florian, Wong, Franklin, De Groot, John, Ackroyd, Jeffrey, Mawlawi, Osama, Davies, Michael A, Gopal, Y N Vashisht, Di Francesco, M Emilia, Marszalek, Joseph R, Dewhirst, Mark, Piwnica-Worms, David

“…Tumors lack a well-regulated vascular supply of O and often fail to balance O supply and demand. Net O tension within many tumors may not only depend on O…”
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Evaluation of the Biodistribution of Serinolamide-Derivatized C60 Fullerene by Zaibaq, Nicholas G., Pollard, Alyssa C., Collins, Michael J., Pisaneschi, Federica, Pagel, Mark D., Wilson, Lon J.

“…Carbon nanoparticles have consistently been of great interest in medicine. However, there are currently no clinical materials based on carbon nanoparticles,…”
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Preclinical evaluation of 3-18F-fluoro-2,2-dimethylpropionic acid as an imaging agent for tumor detection by Witney, Timothy H, Pisaneschi, Federica, Alam, Israt S, Trousil, Sebastian, Kaliszczak, Maciej, Twyman, Frazer, Brickute, Diana, Nguyen, Quang-Dé, Schug, Zachary, Gottlieb, Eyal, Aboagye, Eric O

“…Deregulated cellular metabolism is a hallmark of many cancers. In addition to increased glycolytic flux, exploited for cancer imaging with (18)F-FDG, tumor…”
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Stereodivergent Approach to Enantiopure Hydroxyindolizidines Through 1,3-Dipolar Cycloaddition of 3-Hydroxypyrroline N-Oxide Derivatives by Cordero, Franca M., Pisaneschi, Federica, Gensini, Martina, Goti, Andrea, Brandi, Alberto

“…The (3S)‐3‐alkoxypyrroline N‐oxides 7 and 27 were easily prepared from L‐malic acid and used as starting materials for enantiospecific syntheses of…”
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Selective Ring Contraction of 5-Spirocyclopropane Isoxazolidines Mediated by Acids by Cordero, Franca M, Pisaneschi, Federica, Salvati, Maria, Paschetta, Valentina, Ollivier, Jean, Salaün, Jacques, Brandi, Alberto

“…Thermolysis of 3,4-cis ring-fused 5-spirocyclopropane isoxazolidines 16, 18−21, 33, 34, 38a, and 61, in the presence of a protic acid at 70−110 °C, yielded…”
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A Concise Total Synthesis of (+)-Heliotridine by Pisaneschi, Federica, Cordero, Franca M., Brandi, Alberto

“…A practical synthesis of the necine base (+)‐heliotridine (1) is reported here. The present total synthesis is based on the highly selective 1,3‐dipolar…”
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Imaging of innate immunity activation in vivo with a redox-tuned PET reporter by Pisaneschi, Federica, Gammon, Seth T., Paolillo, Vincenzo, Qureshy, Sarah A., Piwnica-Worms, David

“…High-redox-potential reactive oxygen species and reactive nitrogen species (ROS/RNS), generated by NADPH oxidase-2 (NOX2), myeloperoxidase (MPO) and related…”
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SP-041 - ENBPI ligand for 68Ga: synthesis, radiolabeling optimization, and pilot myocardial perfusion imaging with ECG-gated PET by Muzzioli, Riccardo, Pisaneschi, Federica, Gammon, Seth, Piwnica-Worms, David

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ENBPI ligand for 68Ga: synthesis, radiolabeling optimization, and pilot myocardial perfusion imaging with ECG-gated PET by Muzzioli, Riccardo, Pisaneschi, Federica, Gammon, Seth, Piwnica-Worms, David

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cGMP synthesis of 4-[18F]fluoro-1-naphthol, a novel PET tracer for imaging activation of innate immunity by Pisaneschi, Federica, Paolillo, Vincenzo, Ta, Robert, Lin, Mai, Manning, Charles, Gammon, Seth, Piwnica-Worms, David

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