Search Results - "Pisabarro, M T"

Rational Design of Specific High-Affinity Peptide Ligands for the Abl-SH3 Domain by Pisabarro, M. T, Serrano, L

“…SH3 domains bind proline-rich peptides with affinities in the order of 0.2−50 μM. In general, these domains are quite promiscuous, and the same peptide can…”
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Prediction of Drug Binding Affinities by Comparative Binding Energy Analysis by Ortiz, Angel R, Pisabarro, M. Teresa, Gago, Federico, Wade, Rebecca C

“…A new computational method for deducing quantitative structure-activity relationships (QSARs) using structural data from ligand-macromolecule complexes is…”
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Characterization of interfacial solvent in protein complexes and contribution of wet spots to the interface description by Teyra, Joan, Pisabarro, M. T.

“…Water networks in protein interfaces can complement direct interactions contributing significantly to molecular recognition, function, and stability of protein…”
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Identification of paracaspases and metacaspases: two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma by Uren, A G, O'Rourke, K, Aravind, L A, Pisabarro, M T, Seshagiri, S, Koonin, E V, Dixit, V M

“…Caspases are cysteine proteases essential to apoptosis. We have identified two families of caspase-like proteins, Paracaspases (found in metazoans and…”
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Structure−Function Analysis of a Phage Display-Derived Peptide That Binds to Insulin-like Growth Factor Binding Protein 1 by Skelton, Nicholas J, Chen, Yvonne M, Dubree, Nathan, Quan, Clifford, Jackson, David Y, Cochran, Andrea, Zobel, Kerry, Deshayes, Kurt, Baca, Manuel, Pisabarro, M. Teresa, Lowman, Henry B

“…Highly structured, peptide antagonists of the interaction between insulin-like growth factor 1 (IGF-I) and IGF binding protein 1 (IGFBP-1) have recently been…”
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ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas by Vucic, Domagoj, Stennicke, Henning R., Pisabarro, Maria Teresa, Salvesen, Guy S., Dixit, Vishva M.

“…Background: Inhibitors of apoptosis (IAPs) are a family of cell death inhibitors found in viruses and metazoans. All IAPs have at least one baculovirus IAP…”
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Obligatory steps in protein folding and the conformational diversity of the transition state by Martinez, J C, Pisabarro, M T, Serrano, L

“…We have analyzed the existence of obligatory steps in the folding reaction of the alpha-spectrin SH3 domain by mutating Asp 48 (D48G), which is at position i+3…”
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Origins of PDZ domain ligand specificity. Structure determination and mutagenesis of the Erbin PDZ domain by Skelton, Nicholas J, Koehler, Michael F T, Zobel, Kerry, Wong, Wai Lee, Yeh, Sherry, Pisabarro, M Theresa, Yin, Jian Ping, Lasky, Laurence A, Sidhu, Sachdev S

“…The LAP (leucine-rich repeat and PDZ-containing) family of proteins play a role in maintaining epithelial and neuronal cell size, and mutation of these…”
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A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration by Gille, Hendrik, Kowalski, Joe, Yu, Lanlan, Chen, Helen, Pisabarro, M.Teresa, Davis-Smyth, Terri, Ferrara, Napoleone

“…Vascular endothelial growth factor (VEGF) has two highly homologous tyrosine kinase receptors: Flt‐1 (VEGFR‐1) and KDR (VEGFR‐2). KDR is strongly…”
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Molecular model of the interaction of bee venom phospholipase A2 with manoalide by Ortiz, Angel R, Pisabarro, M. Teresa, Gago, Federico

“…A molecular model of the interaction between manoalide (MLD) and bee venom phospholipase A2 (bv-PLA2) has been derived making use of a combination of…”
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Analysis of PDZ Domain-Ligand Interactions Using Carboxyl-terminal Phage Display by Fuh, Germaine, Pisabarro, M.Teresa, Li, Ying, Quan, Clifford, Lasky, Laurence A., Sidhu, Sachdev S.

“…PDZ domains mediate protein-protein interactions at specialized subcellular sites, such as epithelial cell tight junctions and neuronal post-synaptic…”
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Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions by Pisabarro, M.Teresa, Serrano, Luis, Wilmanns, Matthias

“…The Abl-SH3 domain is implicated in negative regulation of the Abl kinase by mediating protein-protein interactions. High-affinity SH3 ligands could compete…”
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PTEN 2, a Golgi-associated Testis-specific Homologue of the PTEN Tumor Suppressor Lipid Phosphatase by Wu, Yan, Dowbenko, Donald, Pisabarro, M.Teresa, Dillard-Telm, Lisa, Koeppen, Hartmut, Lasky, Laurence A.

“…The tumor suppressor PTEN is a phosphatidylinositol phospholipid phosphatase, which indirectly down-regulates the activity of the protein kinase B/Akt survival…”
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Implications of a consensus recognition site for phosphatidylcholine separate from the active site in cobra venom phospholipases A2 by Ortiz, Angel R, Pisabarro, M. Teresa, Gallego, Jose, Gago, Federico

“…A model structure of Naja naja kaouthia cobra venom phospholipase A2 has been constructed by utilizing molecular modeling techniques. Analysis of the model and…”
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Homology modeling of the Abl-SH3 domain by Pisabarro, M T, Ortiz, A R, Serrano, L, Wade, R C

“…A tertiary structure model of the Abl-SH3 domain is predicted by using homology modeling techniques coupled to molecular dynamics simulations. Two template…”
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Molecular modeling of the interaction of polyproline-based peptides with the Abl-SH3 domain: rational modification of the interaction by Pisabarro, M T, Ortiz, A R, Viguera, A R, Gago, F, Serrano, L

“…A molecular model of the interaction of polyproline-rich peptides with the Abl-SH3 domain is proposed, based on docking calculations with the DOCK program…”
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Rational modification of human synovial fluid phospholipase A2 inhibitors by Pisabarro, M. Teresa, Ortiz, Angel R, Palomer, Albert, Cabre, Francesc, Garcia, Luisa, Wade, Rebecca C, Gago, Federico, Mauleon, David, Carganico, Germano

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Structure Analysis of Two CheY Mutants: Importance of the Hydrogen-Bond Contribution to Protein Stability by Wilcock, Deborah, Pisabarro, María Teresa, López-Hernandez, Eva, Serrano, Luis, Coll, Miquel

“…The crystal structures of two double mutants (F14N/V21T and F14N/V86T) of the signal transduction protein CheY have been determined to a resolution of 2.4 and…”
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An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division by Buchholz, Frank, Kittler, Ralf, Putz, Gabriele, Pelletier, Laurence, Poser, Ina, Heninger, Anne-Kristin, Drechsel, David, Fischer, Steffi, Konstantinova, Irena, Habermann, Bianca, Grabner, Hannes, Yaspo, Marie-Laure, Himmelbauer, Heinz, Korn, Bernd, Neugebauer, Karla, Pisabarro, Maria Teresa

“…RNA interference (RNAi) is an evolutionarily conserved defence mechanism whereby genes are specifically silenced through degradation of messenger RNAs; this…”
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SMAC Negatively Regulates the Anti-apoptotic Activity of Melanoma Inhibitor of Apoptosis (ML-IAP) by Vucic, Domagoj, Deshayes, Kurt, Ackerly, Heidi, Pisabarro, Maria Teresa, Kadkhodayan, Saloumeh, Fairbrother, Wayne J., Dixit, Vishva M.

“…Inhibitors of apoptosis (IAPs) physically interact with a variety of pro-apoptotic proteins and inhibit apoptosis induced by diverse stimuli. X-linked IAP…”
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