Search Results - "Pirraglia, Elizabeth"

Lower mortality risk in APOE4 carriers with normal cognitive ageing by Pirraglia, Elizabeth, Glodzik, Lidia, Shao, Yongzhao

“…Abnormal cognitive ageing, including dementia, poses serious challenges to health and social systems in ageing populations. As such, characterizing factors…”
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Obstructive Sleep Apnea Severity Affects Amyloid Burden in Cognitively Normal Elderly. A Longitudinal Study by Sharma, Ram A, Varga, Andrew W, Bubu, Omonigho M, Pirraglia, Elizabeth, Kam, Korey, Parekh, Ankit, Wohlleber, Margaret, Miller, Margo D, Andrade, Andreia, Lewis, Clifton, Tweardy, Samuel, Buj, Maja, Yau, Po L, Sadda, Reem, Mosconi, Lisa, Li, Yi, Butler, Tracy, Glodzik, Lidia, Fieremans, Els, Babb, James S, Blennow, Kaj, Zetterberg, Henrik, Lu, Shou E, Badia, Sandra G, Romero, Sergio, Rosenzweig, Ivana, Gosselin, Nadia, Jean-Louis, Girardin, Rapoport, David M, de Leon, Mony J, Ayappa, Indu, Osorio, Ricardo S

“…Recent evidence suggests that obstructive sleep apnea (OSA) may be a risk factor for developing mild cognitive impairment and Alzheimer's disease. However, how…”
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Obstructive sleep apnea and longitudinal Alzheimer's disease biomarker changes by Bubu, Omonigho M, Pirraglia, Elizabeth, Andrade, Andreia G, Sharma, Ram A, Gimenez-Badia, Sandra, Umasabor-Bubu, Ogie Q, Hogan, Megan M, Shim, Amanda M, Mukhtar, Fahad, Sharma, Nidhi, Mbah, Alfred K, Seixas, Azizi A, Kam, Korey, Zizi, Ferdinand, Borenstein, Amy R, Mortimer, James A, Kip, Kevin E, Morgan, David, Rosenzweig, Ivana, Ayappa, Indu, Rapoport, David M, Jean-Louis, Girardin, Varga, Andrew W, Osorio, Ricardo S

“…To determine the effect of self-reported clinical diagnosis of obstructive sleep apnea (OSA) on longitudinal changes in brain amyloid PET and CSF biomarkers…”
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The interaction between sleep-disordered breathing and apolipoprotein E genotype on cerebrospinal fluid biomarkers for Alzheimer's disease in cognitively normal elderly individuals by Osorio, Ricardo S, Ayappa, Indu, Mantua, Janna, Gumb, Tyler, Varga, Andrew, Mooney, Anne M, Burschtin, Omar E, Taxin, Zachary, During, Emmanuel, Spector, Nicole, Biagioni, Milton, Pirraglia, Elizabeth, Lau, Hiuyan, Zetterberg, Henrik, Blennow, Kaj, Lu, Shou-En, Mosconi, Lisa, Glodzik, Lidia, Rapoport, David M, de Leon, Mony J

“…Abstract Previous studies have suggested a link between sleep disordered breathing (SDB) and dementia risk. In the present study, we analyzed the relationship…”
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Plasma tau complements CSF tau and P-tau in the diagnosis of Alzheimer's disease by Fossati, Silvia, Ramos Cejudo, Jaime, Debure, Ludovic, Pirraglia, Elizabeth, Sone, Je Yeong, Li, Yi, Chen, Jingyun, Butler, Tracy, Zetterberg, Henrik, Blennow, Kaj, de Leon, Mony J.

“…Plasma tau may be an accessible biomarker for Alzheimer's disease (AD), but the correlation between plasma and cerebrospinal fluid (CSF) tau and the value of…”
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Decreased CSF clearance and increased brain amyloid in Alzheimer's disease by Li, Yi, Rusinek, Henry, Butler, Tracy, Glodzik, Lidia, Pirraglia, Elizabeth, Babich, John, Mozley, P David, Nehmeh, Sadek, Pahlajani, Silky, Wang, Xiuyuan, Tanzi, Emily B, Zhou, Liangdong, Strauss, Sara, Carare, Roxana O, Theise, Neil, Okamura, Nobuyuki, de Leon, Mony J

“…In sporadic Alzheimer's disease (AD), brain amyloid-beta (Aβ) deposition is believed to be a consequence of impaired Aβ clearance, but this relationship is not…”
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The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer's disease by de Leon, Mony J, Pirraglia, Elizabeth, Osorio, Ricardo S, Glodzik, Lidia, Saint-Louis, Les, Kim, Hee-Jin, Fortea, Juan, Fossati, Silvia, Laska, Eugene, Siegel, Carole, Butler, Tracy, Li, Yi, Rusinek, Henry, Zetterberg, Henrik, Blennow, Kaj

“…Cerebrospinal fluid (CSF) studies consistently show that CSF levels of amyloid-beta 1-42 (Aβ42) are reduced and tau levels increased prior to the onset of…”
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Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease by Li, Yi, Rinne, Juha O., Mosconi, Lisa, Pirraglia, Elizabeth, Rusinek, Henry, DeSanti, Susan, Kemppainen, Nina, Någren, Kjell, Kim, Byeong-Chae, Tsui, Wai, de Leon, Mony J.

“…Objective The objective of the study is to compare the diagnostic value of regional sampling of the cerebral metabolic rate of glucose metabolism (MRglc) using…”
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Maternal family history of Alzheimer's disease predisposes to reduced brain glucose metabolism by Mosconi, Lisa, Brys, Miroslaw, Switalski, Remigiusz, Mistur, Rachel, Glodzik, Lidia, Pirraglia, Elizabeth, Tsui, Wai, De Santi, Susan, de Leon, Mony J

“…Having a parent affected with late-onset Alzheimer's disease (AD) is a risk factor for developing AD among cognitively normal subjects. We examined whether…”
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Prediction and longitudinal study of CSF biomarkers in mild cognitive impairment by Brys, Miroslaw, Pirraglia, Elizabeth, Rich, Kenneth, Rolstad, Sindre, Mosconi, Lisa, Switalski, Remigiusz, Glodzik-Sobanska, Lidia, De Santi, Susan, Zinkowski, Ray, Mehta, Pankaj, Pratico, Domenico, Saint Louis, Leslie A, Wallin, Anders, Blennow, Kaj, de Leon, Mony J

“…Abstract Objectives To longitudinally evaluate five cerebrospinal fluid (CSF) biomarkers in the transition from mild cognitive impairment (MCI) to Alzheimer's…”
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Reduced retention of Pittsburgh compound B in white matter lesions by Glodzik, Lidia, Rusinek, Henry, Li, Jinyu, Zhou, Cyrus, Tsui, Wai, Mosconi, Lisa, Li, Yi, Osorio, Ricardo, Williams, Schantel, Randall, Catherine, Spector, Nicole, McHugh, Pauline, Murray, John, Pirraglia, Elizabeth, Vallabhajolusa, Shankar, de Leon, Mony

“…Purpose One of the interesting features of the amyloid tracer Pittsburgh compound B (PiB) is that it generates a signal in the white matter (WM) in both…”
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Does mild cognitive impairment increase the risk of developing postoperative cognitive dysfunction? by Bekker, Alex, M.D., Ph.D, Lee, Cynthia, B.S, de Santi, Susan, Ph.D, Pirraglia, Elizabeth, M.S, Zaslavsky, Alexander, M.D, Farber, Sonya, M.A, Haile, Michael, M.D, de Leon, Mony J., Ed.D

“…Abstract Background Increasingly, postoperative cognitive dysfunction (POCD) is recognized as a complication after surgery in the elderly. We sought to…”
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Cortical laminar binding of PET amyloid and tau tracers in Alzheimer disease by Li, Yi, Tsui, Wai, Rusinek, Henry, Butler, Tracy, Mosconi, Lisa, Pirraglia, Elizabeth, Mozley, David, Vallabhajosula, Shankar, Harada, Ryuichi, Furumoto, Shozo, Furukawa, Katsutoshi, Arai, Hiroyuki, Kudo, Yukitsuka, Okamura, Nobuyuki, de Leon, Mony J

“…Neurofibrillary tau pathology and amyloid β (Aβ) plaques, characteristic lesions of Alzheimer disease (AD), show different neocortical laminar distributions…”
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Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET by de Leon, Mony J, Li, Yi, Okamura, Nobuyuki, Tsui, Wai H, Saint-Louis, Les A, Glodzik, Lidia, Osorio, Ricardo S, Fortea, Juan, Butler, Tracy, Pirraglia, Elizabeth, Fossati, Silvia, Kim, Hee-Jin, Carare, Roxana O, Nedergaard, Maiken, Benveniste, Helene, Rusinek, Henry

“…Evidence supporting the hypothesis that reduced cerebrospinal fluid (CSF) clearance is involved in the pathophysiology of Alzheimer disease (AD) comes…”
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Sleep-disordered breathing advances cognitive decline in the elderly by Osorio, Ricardo S, Gumb, Tyler, Pirraglia, Elizabeth, Varga, Andrew W, Lu, Shou-en, Lim, Jason, Wohlleber, Margaret E, Ducca, Emma L, Koushyk, Viachaslau, Glodzik, Lidia, Mosconi, Lisa, Ayappa, Indu, Rapoport, David M, de Leon, Mony J

“…OBJECTIVE:To examine whether the presence of sleep-disordered breathing (SDB) is associated with an earlier age at mild cognitive impairment (MCI) or Alzheimer…”
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Periodontal disease associates with higher brain amyloid load in normal elderly by Kamer, Angela R, Pirraglia, Elizabeth, Tsui, Wai, Rusinek, Henry, Vallabhajosula, Shankar, Mosconi, Lisa, Yi, Li, McHugh, Pauline, Craig, Ronald G, Svetcov, Spencer, Linker, Ross, Shi, Chen, Glodzik, Lidia, Williams, Schantel, Corby, Patricia, Saxena, Deepak, de Leon, Mony J

“…Abstract The accumulation of amyloid-β (Aβ) plaques is a central feature of Alzheimer's disease (AD). First reported in animal models, it remains uncertain if…”
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Multifocal repetitive TMS for motor and mood symptoms of Parkinson disease: A randomized trial by Brys, Miroslaw, Fox, Michael D, Agarwal, Shashank, Biagioni, Milton, Dacpano, Geraldine, Kumar, Pawan, Pirraglia, Elizabeth, Chen, Robert, Wu, Allan, Fernandez, Hubert, Shukla, Aparna Wagle, Lou, Jau-Shin, Gray, Zachary, Simon, David K, Di Rocco, Alessandro, Pascual-Leone, Alvaro

“…OBJECTIVE:To assess whether multifocal, high-frequency repetitive transcranial magnetic stimulation (rTMS) of motor and prefrontal cortex benefits motor and…”
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Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly by Varga, Andrew W., Wohlleber, Margaret E., Giménez, Sandra, Romero, Sergio, Alonso, Joan F., Ducca, Emma L., Kam, Korey, Lewis, Clifton, Tanzi, Emily B., Tweardy, Samuel, Kishi, Akifumi, Parekh, Ankit, Fischer, Esther, Gumb, Tyler, Alcolea, Daniel, Fortea, Juan, Lleó, Alberto, Blennow, Kaj, Zetterberg, Henrik, Mosconi, Lisa, Glodzik, Lidia, Pirraglia, Elizabeth, Burschtin, Omar E., de Leon, Mony J., Rapoport, David M., Lu, Shou-en, Ayappa, Indu, Osorio, Ricardo S.

“…Abstract Study Objectives: Emerging evidence suggests a role for sleep in contributing to the progression of Alzheimer disease (AD). Slow wave sleep (SWS) is…”
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FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease by Mosconi, Lisa, Mistur, Rachel, Switalski, Remigiusz, Tsui, Wai Hon, Glodzik, Lidia, Li, Yi, Pirraglia, Elizabeth, De Santi, Susan, Reisberg, Barry, Wisniewski, Thomas, de Leon, Mony J.

“…Purpose We report the first clinicopathological series of longitudinal FDG-PET scans in post-mortem (PM) verified cognitively normal elderly (NL) followed to…”
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Traumatic brain injury and age at onset of cognitive decline in corticobasal degeneration, corticobasal syndrome, and progressive supranuclear palsy by Spiegel, Jonathan, Sone, Je Yeong, Butler, Tracy, Pirraglia, Elizabeth, de Leon, Mony J.

“…Background Traumatic brain injury (TBI) has been repeatedly shown to be a risk factor for several neurodegenerative diseases. However, no studies have yet…”
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