Search Results - "Pirot, P"

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis by Allagnat, F, Christulia, F, Ortis, F, Pirot, P, Lortz, S, Lenzen, S, Eizirik, D. L, Cardozo, A. K

“…Aims/hypothesis Pro-inflammatory cytokines involved in the pathogenesis of type 1 diabetes deplete endoplasmic reticulum (ER) Ca²⁺ stores, leading to ER-stress…”
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Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs by Pirot, P, Naamane, N, Libert, F, Magnusson, N. E, Ørntoft, T. F, Cardozo, A. K, Eizirik, D. L

“…Aims/hypothesis Pancreatic beta cells respond to endoplasmic reticulum (ER) stress by activating the unfolded protein response. If the stress is prolonged, or…”
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Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells by Ortis, F, Pirot, P, Naamane, N, Kreins, A. Y, Rasschaert, J, Moore, F, Théâtre, E, Verhaeghe, C, Magnusson, N. E, Chariot, A, Ørntoft, T. F, Eizirik, D. L

“…Aims/hypothesis IL-1β and TNF-α contribute to pancreatic beta cell death in type 1 diabetes. Both cytokines activate the transcription factor nuclear factor-κB…”
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Interferon-γ potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms by PIROT, P, EIZIRIK, D. L, CARDOZO, A. K

“…A tight control of endoplasmic reticulum homeostasis is crucial for beta cell function and survival. We recently described that IL-1beta plus IFN-gamma deplete…”
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Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells by Ortis, F, Pirot, P, Naamane, N, Kreins, A Y, Rasschaert, J, Moore, F, Théâtre, E, Verhaeghe, C, Magnusson, N E, Chariot, A, Orntoft, T F, Eizirik, D L

“…IL-1beta and TNF-alpha contribute to pancreatic beta cell death in type 1 diabetes. Both cytokines activate the transcription factor nuclear factor-kappaB…”
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Interferon-[gamma] potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms by Pirot, P, Eizirik, D L, Cardozo, A K

“…A tight control of endoplasmic reticulum homeostasis is crucial for beta cell function and survival. We recently described that IL-1beta plus IFN-gamma deplete…”
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Direct regulation of the Nrarp gene promoter by the Notch signaling pathway by Pirot, Pierre, Grunsven, Leo A. van, Marine, Jean-Christophe, Huylebroeck, Danny, Bellefroid, Eric J.

“…Nrarp encodes for an evolutionarily conserved small ankyrin repeat-containing protein that functions as a negative regulator of Notch signaling. Interestingly,…”
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Induction of nuclear factor-[kappa]B and its downstream genes by TNF-[alpha] and IL-1[beta] has a pro-apoptotic role in pancreatic beta cells by Ortis, F, Pirot, P, Naamane, N, Kreins, A Y, Rasschaert, J, Moore, F, Théâtre, E, Verhaeghe, C, Magnusson, N E, Chariot, A, Ørntoft, T F, Eizirik, D L

“…IL-1β and TNF-α contribute to pancreatic beta cell death in type 1 diabetes. Both cytokines activate the transcription factor nuclear factor-κB (NF-κB), but…”
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Induction of nuclear factor-KB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells by ORTIS, F, PIROT, P, ORNTOFT, T. F, EIZIRIK, D. L, NAAMANE, N, KREINS, A. Y, RASSCHAERT, J, MOORE, F, THEATRE, E, VERHAEGHE, C, MAGNUSSON, N. E, CHARIOT, A

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