Search Results - "Pirondi, Silvia"
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Optimization of Peptides That Target Human Thymidylate Synthase to Inhibit Ovarian Cancer Cell Growth
Published in Journal of medicinal chemistry (27-02-2014)“…Thymidylate synthase (TS) is a target for pemetrexed and the prodrug 5-fluorouracil (5-FU) that inhibit the protein by binding at its active site. Prolonged…”
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Internalization and Stability of a Thymidylate Synthase Peptide Inhibitor in Ovarian Cancer Cells
Published in Journal of medicinal chemistry (26-12-2014)“…Information on the cellular internalization and stability of the ovarian cancer cell growth inhibitor peptide, LSCQLYQR (LR), is vital for lead optimization…”
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Mass Spectrometric/Bioinformatic Identification of a Protein Subset That Characterizes the Cellular Activity of Anticancer Peptides
Published in Journal of proteome research (07-11-2014)“…The preclinical study of the mechanism of action of anticancer small molecules is challenging due to the complexity of cancer biology and the fragmentary…”
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Biological evaluation of MR36, a novel non-polyglutamatable thymidylate synthase inhibitor that blocks cell cycle progression in melanoma cell lines
Published in Investigational new drugs (01-08-2012)“…Summary Melanoma is one of the most common cancers, and its incidence has continued to increase over the past few decades. Chemotherapy resistance and related…”
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