Search Results - "Piron, Julien"

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation by Coyan, Fabien C, Abderemane-Ali, Fayal, Amarouch, Mohamed Yassine, Piron, Julien, Mordel, Jérôme, Nicolas, Céline S, Steenman, Marja, Mérot, Jean, Marionneau, Céline, Thomas, Annick, Brasseur, Robert, Baró, Isabelle, Loussouarn, Gildas

“…Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1, including R243H,…”
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Impaired KCNQ1–KCNE1 and Phosphatidylinositol-4,5-Bisphosphate Interaction Underlies the Long QT Syndrome by Park, Kyu-Ho, Piron, Julien, Dahimene, Shehrazade, Mérot, Jean, Baró, Isabelle, Escande, Denis, Loussouarn, Gildas

“…Nearly a hundred different KCNQ1 mutations have been reported as leading to the cardiac long QT syndrome, characterized by prolonged QT interval, syncopes, and…”
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Phosphatidylinositol-4,5-Bisphosphate (PIP2) Stabilizes the Open Pore Conformation of the Kv11.1 (hERG) Channel by Rodriguez, Nicolas, Amarouch, Mohamed Yassine, Montnach, Jérôme, Piron, Julien, Labro, Alain J., Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas

“…Phosphatidylinositol-4,5-bisphosphate (PIP2) is a phospholipid that has been shown to modulate several ion channels, including some voltage-gated channels like…”
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Doxorubicin Delivery into Tumor Cells with Ultrasound and Microbubbles by Escoffre, J. M, Piron, J, Novell, A, Bouakaz, A

“…Doxorubicin is a potent chemotherapeutic whose severe side effects limit its application. Drug-targeted delivery with noninvasive techniques is required to…”
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Microbubble attenuation and destruction: are they involved in sonoporation efficiency? by Escoffre, J., Novell, A., Piron, J., Zeghimi, A., Doinikov, A., Bouakaz, A.

“…This technical note investigates the involvement of microbubble attenuation and destruction in sonoporation mechanisms. First, we evaluate sonoporation…”
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KCNE1–KCNQ1 osmoregulation by interaction of phosphatidylinositol‐4,5‐bisphosphate with Mg2+ and polyamines by Piron, Julien, Choveau, Frank S., Amarouch, Mohammed Yassine, Rodriguez, Nicolas, Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas

“…KCNQ1 osmosensitivity is of physiological and pathophysiological relevance in epithelial and cardiac cells, but the mechanism involved remains elusive. In…”
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In KCNQ1 Channels, a Long QT Mutation Induces a Regulation by Cholesterol Instead of Phosphatidylinositol-4,5-Bisphosphate by Coyan, Fabien C., Amarouch, Mohamed-Yassine, Abderemane Ali, Fayal, Piron, Julien, Mordel, Jérome, Nicolas, Céline S., Steenman, Marja, Mérot, Jean, Marionneau, Céline, Thomas, Annick, Brasseur, Robert, Baró, Isabelle, Loussouarn, Gildas

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Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block by Bignolais, Olivier, Quang, Khai Le, Naud, Patrice, El Harchi, Aziza, Briec, François, Piron, Julien, Bourge, Anne, Leoni, Anne-Laure, Charpentier, Flavien, Demolombe, Sophie

“…Abstract Complete atrioventricular block (CAVB) and related ventricular bradycardia are known to induce ventricular hypertrophy and arrhythmias. Different…”
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Biological Pacemaker Engineered by Nonviral Gene Transfer in a Mouse Model of Complete Atrioventricular Block by Piron, Julien, Quang, Khai Le, Briec, François, Amirault, Jean-Christophe, Leoni, Anne-Laure, Desigaux, Léa, Escande, Denis, Pitard, Bruno, Charpentier, Flavien

“…We hypothesized that a nonviral gene delivery of the hyperpolarization-activated HCN2 channel combined with the β2-adrenergic receptor (ADRB2) would generate a…”
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KCNE1-KCNQ1 osmoregulation by interaction of phosphatidylinositol-4,5-bisphosphate with Mg 2+ and polyamines: Mechanism of KCNE1-KCNQ1 osmoregulation by Piron, Julien, Choveau, Frank S., Amarouch, Mohammed Yassine, Rodriguez, Nicolas, Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas

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KCNQ1-R539W Mutation Substitutes Cholesterol for Phosphatidylinositol-4, 5-Bisphosphate in Channel Regulation by Piron, Julien, Amarouch, Mohamed Yassine, Mordel, Jérôme, Nicolas, Céline S., Thomas, Annick, Brasseur, Robert, Charpentier, Flavien, Mérot, Jean, Baró, Isabelle, Loussouarn, Gildas

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A Long QT Mutation Substitutes Cholesterol for Phosphatidylinositol-4,5-Bisphosphate in KCNQ1 Channel Regulation: e93255 by Coyan, Fabien C, Abderemane-Ali, Fayal, Amarouch, Mohamed Yassine, Piron, Julien, Mordel, Jerome, Nicolas, Celine S, Steenman, Marja, Merot, Jean, Marionneau, Celine, Thomas, Annick

“…Introduction Phosphatidylinositol-4,5-bisphosphate (PIP2) is a cofactor necessary for the activity of KCNQ1 channels. Some Long QT mutations of KCNQ1,…”
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Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity by ROYER, Anne, DEMOLOMBE, Sophie, MOTOIKE, Howard K, CHEVALLIER, Jean-Christophe, LOUSSOUAM, Gildas, CLANCY, Colleen E, ESCANDE, Denis, CHARPENTIER, Flavien, AZIZA EL HARCHI, KHAÏ LE QUANG, PIRON, Julien, TOUMANIANTZ, Gilles, MAZURAIS, David, BELLOCQ, Chloé, LANDE, Gilles, TERRENOIRE, Cécile

“…The K(+) channel encoded by the human ether-a-go-go-related gene (HERG) is crucial for repolarization in the human heart. In order to investigate the impact of…”
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Enhanced gene transfection using ultrasound and Vevo Micromarker® microbubbles: Microbubbles-assisted ultrasound and gene delivery by Piron, Julien, Escoffre, Jean-Michel, Kaddur, Kadija, Novell, Anthony, Bouakaz, Ayache

“…Contrast agents for ultrasound imaging, composed of tiny gas microbubbles, have become a reality in clinical routine. Recent experimental studies showed that…”
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Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles by Piron, J., Kaddur, K., Bouakaz, A.

“…Doxorubicin is an important potent anti-cancer drug and is used for the treatment of various malignancies. Although its effectiveness is proved, its adverse…”
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