Search Results - "Pirollo, Kathleen"

Targeted nanocomplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide by Kim, Sang-Soo, Harford, Joe B, Moghe, Manish, Rait, Antonina, Pirollo, Kathleen F, Chang, Esther H

“…Abstract Intrinsic therapeutic resistance especially in cancer stem cells (CSCs) together with extensive tumor cell infiltration and restricted permeation of…”
Get full text

Effective treatment of glioblastoma requires crossing the blood–brain barrier and targeting tumors including cancer stem cells: The promise of nanomedicine by Kim, Sang-Soo, Harford, Joe B., Pirollo, Kathleen F., Chang, Esther H.

“…Glioblastoma multiforme (GBM) is the most aggressive and lethal type of brain tumor. Both therapeutic resistance and restricted permeation of drugs across the…”
Get full text

Phase I Study of a Systemically Delivered p53 Nanoparticle in Advanced Solid Tumors by Senzer, Neil, Nemunaitis, John, Nemunaitis, Derek, Bedell, Cynthia, Edelman, Gerald, Barve, Minal, Nunan, Robert, Pirollo, Kathleen F, Rait, Antonina, Chang, Esther H

“…Selective delivery of therapeutic molecules to primary and metastatic tumors is optimal for effective cancer therapy. A liposomal nanodelivery complex (scL)…”
Get full text

Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study by Pirollo, Kathleen F, Nemunaitis, John, Leung, Po Ki, Nunan, Robert, Adams, Jana, Chang, Esther H

“…Loss of p53 suppressor function, through mutations or inactivation of the p53 pathway, occurs in most human cancers. SGT-53 is a liposomal nanocomplex designed…”
Get full text

Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma by Kim, Sang-Soo, Rait, Antonina, Kim, Eric, DeMarco, James, Pirollo, Kathleen F, Chang, Esther H

“…Highlights • GBM is the most aggressive and lethal type of brain tumor with a poor prognosis. • Novel strategies are needed to improve limited efficacy of TMZ…”
Get full text

A Nanoparticle Carrying the p53 Gene Targets Tumors Including Cancer Stem Cells, Sensitizes Glioblastoma to Chemotherapy and Improves Survival by Kim, Sang-Soo, Rait, Antonina, Kim, Eric, Pirollo, Kathleen F, Nishida, Maki, Farkas, Natalia, Dagata, John A, Chang, Esther H

“…Temozolomide (TMZ)-resistance in glioblastoma multiforme (GBM) has been linked to upregulation of O 6-methylguanine-DNA methyltransferase (MGMT). Wild-type…”
Get full text

Integrated Genomic and Functional microRNA Analysis Identifies miR-30-5p as a Tumor Suppressor and Potential Therapeutic Nanomedicine in Head and Neck Cancer by Saleh, Anthony D, Cheng, Hui, Martin, Scott E, Si, Han, Ormanoglu, Pinar, Carlson, Sophie, Clavijo, Paul E, Yang, Xinping, Das, Rita, Cornelius, Shaleeka, Couper, Jamie, Chepeha, Douglas, Danilova, Ludmila, Harris, Thomas M, Prystowsky, Michael B, Childs, Geoffrey J, Smith, Richard V, Robertson, A Gordon, Jones, Steven J M, Cherniack, Andrew D, Kim, Sang S, Rait, Antonina, Pirollo, Kathleen F, Chang, Esther H, Chen, Zhong, Van Waes, Carter

“…To identify deregulated and inhibitory miRNAs and generate novel mimics for replacement nanomedicine for head and neck squamous cell carcinomas (HNSCC). We…”
Get full text

TP53 Gene Therapy as a Potential Treatment for Patients with COVID-19 by Harford, Joe B, Kim, Sang Soo, Pirollo, Kathleen F, Chang, Esther H

“…SGT-53 is a novel investigational agent that comprises an immunoliposome carrying a plasmid vector driving expression of the human gene that encodes wild-type…”
Get full text

A Pralidoxime Nanocomplex Formulation Targeting Transferrin Receptors for Reactivation of Brain Acetylcholinesterase After Exposure of Mice to an Anticholinesterase Organophosphate by Pirollo, Kathleen F, Moghe, Manish, Guan, Miaoyin, Rait, Antonina S, Wang, Aibing, Kim, Sang-Soo, Chang, Esther H, Harford, Joe B

“…Organophosphates are among the deadliest of known chemicals based on their ability to inactivate acetylcholinesterase in neuromuscular junctions and synapses…”
Get full text

scL-2PAM: A Novel Countermeasure That Ameliorates Neuroinflammation and Neuronal Losses in Mice Exposed to an Anticholinesterase Organophosphate by Moghe, Manish, Kim, Sang-Soo, Guan, Miaoyin, Rait, Antonina, Pirollo, Kathleen F, Harford, Joe B, Chang, Esther H

“…Due to their inhibition of acetylcholinesterase, organophosphates are among the most toxic of chemicals. Pralidoxime (a.k.a 2-PAM) is the only…”
Get full text

Targeted Delivery of Small Interfering RNA : Approaching Effective Cancer Therapies by PIROLLO, Kathleen F, CHANG, Esther H

“…Three of the primary requirements for the development of effective dual-targeting therapeutic modalities for the treatment of cancer are the tumor-targeted…”
Get full text

A Phase l Study of a Tumor-targeted Systemic Nanodelivery System, SGT-94, in Genitourinary Cancers by Siefker-Radtke, Arlene, Zhang, Xin-qiao, Guo, Charles C, Shen, Yu, Pirollo, Kathleen F, Sabir, Sharjeel, Leung, Chris, Leong-Wu, Cindy, Ling, Chi-Ming, Chang, Esther H, Millikan, Randall E, Benedict, William F

“…Gene therapy development has been limited by our inability to target multifocal cancer with systemic delivery. We developed a systemically administered,…”
Get full text

The Clinical Potential of Targeted Nanomedicine: Delivering to Cancer Stem-like Cells by Kim, Sang-Soo, Rait, Antonina, Rubab, Farwah, Rao, Abhi K, Kiritsy, Michael C, Pirollo, Kathleen F, Wang, Shangzi, Weiner, Louis M, Chang, Esther H

“…Cancer stem-like cells (CSCs) have been implicated in recurrence and treatment resistance in many human cancers. Thus, a CSC-targeted drug delivery strategy to…”
Get full text

Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system by PIROLLO, Kathleen F, RAIT, Antonina, QI ZHOU, SUNG HEE HWANG, DAGATA, John A, ZON, Gerald, HOGREFE, Richard I, PALCHIK, Guillermo, CHANG, Esther H

“…The field of small interfering RNA (siRNA) as potent sequence-selective inhibitors of transcription is rapidly developing. However, until now, low transfection…”
Get full text

Nanotherapeutics for Gene Modulation that Prevents Apoptosis in the Brain and Fatal Neuroinflammation by Kim, Sang-Soo, Rait, Antonina, Garrido-Sanabria, Emilio R., Pirollo, Kathleen F., Harford, Joe B., Chang, Esther H.

“…The failure of therapeutic agents to cross the blood-brain barrier (BBB) has been a major impediment in the treatment of neurological disorders and brain…”
Get full text

Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53‐altered tumors by Gunaratne, Preethi H., Pan, Yinghong, Rao, Abhi K., Lin, Chunru, Hernandez‐Herrera, Anadulce, Liang, Ke, Rait, Antonina S., Venkatanarayan, Avinashnarayan, Benham, Ashley L., Rubab, Farwah, Kim, Sang Soo, Rajapakshe, Kimal, Chan, Clara K., Mangala, Lingegowda S., Lopez‐Berestein, Gabriel, Sood, Anil K., Rowat, Amy C., Coarfa, Cristian, Pirollo, Kathleen F., Flores, Elsa R., Chang, Esther H.

“…Background Over 96% of high‐grade ovarian carcinomas and 50% of all cancers are characterized by alterations in the p53 gene. Therapeutic strategies to restore…”
Get full text

Nanomedicine-Based Gene Delivery for a Truncated Tumor Suppressor RB94 Promotes Lung Cancer Immunity by Kim, Sang-Soo, Doherty, Caroline, Moghe, Manish, Rait, Antonina, Pirollo, Kathleen F, Harford, Joe B, Chang, Esther H

“…Because lung cancer remains the most common and lethal of cancers, novel therapeutic approaches are urgently needed. RB94 is a truncated form of retinoblastoma…”
Get full text

A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme by Kim, Sang-Soo, PhD, Rait, Antonina, PhD, Kim, Eric, BSc, Pirollo, Kathleen F., PhD, Chang, Esther H., PhD

“…Abstract Development of temozolomide (TMZ) resistance contributes to the poor prognosis for glioblastoma multiforme (GBM) patients. It was previously…”
Get full text

Does a targeting ligand influence nanoparticle tumor localization or uptake? by Pirollo, Kathleen F, Chang, Esther H

“…Inclusion of a tumor-targeting molecule in nanosized delivery systems increases their in vivo efficacy. However, the biodistribution and pharmacokinetics of…”
Get full text

Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo by Yang, Chengli, PhD, Rait, Antonina, PhD, Pirollo, Kathleen F., PhD, Dagata, John A., PhD, Farkas, Natalia, PhD, Chang, Esther H., PhD

“…Abstract To circumvent the problem of reduction of the supermagnetic properties of superparamagnetic iron oxide (SPIO) nanoparticles after chemical…”
Get full text