Search Results - "Piro, Justin R"

Isolation of phosphatidylethanolamine as a solitary cofactor for prion formation in the absence of nucleic acids by Deleault, Nathan R, Piro, Justin R, Walsh, Daniel J, Wang, Fei, Ma, Jiyan, Geoghegan, James C, Supattapone, Surachai

“…Infectious prions containing the pathogenic conformer of the mammalian prion protein (PrPSc) can be produced de novo from a mixture of the normal conformer…”
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Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions by Deleault, Nathan R, Walsh, Daniel J, Piro, Justin R, Wang, Fei, Wang, Xinhe, Ma, Jiyan, Rees, Judy R, Supattapone, Surachai

“…Prions containing misfolded prion protein (PrP Sᶜ) can be formed with cofactor molecules using the technique of serial protein misfolding cyclic amplification…”
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A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease by Piro, Justin R., Benjamin, Daniel I., Duerr, James M., Pi, YeQing, Gonzales, Cathleen, Wood, Kathleen M., Schwartz, Joel W., Nomura, Daniel K., Samad, Tarek A.

“…Although inflammation in the brain is meant as a defense mechanism against neurotoxic stimuli, increasing evidence suggests that uncontrolled, chronic, and…”
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Inhibition of monoacylglycerol lipase terminates diazepam‐resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet by Terrone, Gaetano, Pauletti, Alberto, Salamone, Alessia, Rizzi, Massimo, Villa, Bianca R., Porcu, Luca, Sheehan, Mark J., Guilmette, Edward, Butler, Christopher R., Piro, Justin R., Samad, Tarek A., Vezzani, Annamaria

“…Summary Objective Status epilepticus (SE) is a life‐threatening and commonly drug‐refractory condition. Novel therapies are needed to rapidly terminate…”
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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation by McAllister, Laura A, Butler, Christopher R, Mente, Scot, O’Neil, Steven V, Fonseca, Kari R, Piro, Justin R, Cianfrogna, Julie A, Foley, Timothy L, Gilbert, Adam M, Harris, Anthony R, Helal, Christopher J, Johnson, Douglas S, Montgomery, Justin I, Nason, Deane M, Noell, Stephen, Pandit, Jayvardhan, Rogers, Bruce N, Samad, Tarek A, Shaffer, Christopher L, da Silva, Rafael G, Uccello, Daniel P, Webb, Damien, Brodney, Michael A

“…Monoacylglycerol lipase (MAGL) inhibition provides a potential treatment approach to neuroinflammation through modulation of both the endocannabinoid pathway…”
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Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase by Butler, Christopher R., Beck, Elizabeth M., Harris, Anthony, Huang, Zhen, McAllister, Laura A., am Ende, Christopher W., Fennell, Kimberly, Foley, Timothy L., Fonseca, Kari, Hawrylik, Steven J., Johnson, Douglas S., Knafels, John D., Mente, Scot, Noell, G. Stephen, Pandit, Jayvardhan, Phillips, Tracy B., Piro, Justin R., Rogers, Bruce N., Samad, Tarek A., Wang, Jane, Wan, Shuangyi, Brodney, Michael A.

“…Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes…”
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Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury by Piro, Justin R, Suidan, Georgette L, Quan, Jie, Pi, YeQing, O'Neill, Sharon M, Ilardi, Marissa, Pozdnyakov, Nikolay, Lanz, Thomas A, Xi, Hualin, Bell, Robert D, Samad, Tarek A

“…Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain…”
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Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development by Biber, Knut, Bhattacharya, Anindya, Campbell, Brian M, Piro, Justin R, Rohe, Michael, Staal, Roland G W, Talanian, Robert V, Möller, Thomas

“…Alzheimer's disease (AD) is a large and increasing unmet medical need with no disease-modifying treatment currently available. Genetic evidence from…”
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Prion Protein Glycosylation Is Not Required for Strain-Specific Neurotropism by PIRO, Justin R, HARRIS, Brent T, NISHINA, Koren, SOTO, Claudio, MORALES, Rodrigo, REES, Judy R, SUPATTAPONE, Surachai

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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In situ photodegradation of incorporated polyanion does not alter prion infectivity by Piro, Justin R, Harris, Brent T, Supattapone, Surachai

“…Single-stranded polyanions ≥40 bases in length facilitate the formation of hamster scrapie prions in vitro, and polyanions co-localize with PrP(Sc) aggregates…”
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Target occupancy study and whole-body dosimetry with a MAGL PET ligand [11C]PF-06809247 in non-human primates by Arakawa, Ryosuke, Takano, Akihiro, Nag, Sangram, Jia, Zhisheng, Amini, Nahid, Maresca, Kevin P., Zhang, Lei, Keliher, Edmund J., Butler, Christopher R., Piro, Justin R., Samad, Tarek A., Smith, Deborah, Nason, Deane, O’Neil, Steve, Trapa, Patrick, Fonseca, Kari R., Litchfield, John, McCarthy, Timothy, Carson, Richard E., Halldin, Christer

“…Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven…”
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Photodegradation illuminates the role of polyanions in prion infectivity by Piro, Justin R., Supattapone, Surachai

“…Understanding the mechanism by which prion infectivity is encoded by the misfolded protein PrP Sc remains a high priority within the prion field. Work from…”
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Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity by Zhang, Lei, Butler, Christopher R, Maresca, Kevin P, Takano, Akihiro, Nag, Sangram, Jia, Zhisheng, Arakawa, Ryosuke, Piro, Justin R, Samad, Tarek, Smith, Deborah L, Nason, Deane M, O’Neil, Steven, McAllister, Laura, Schildknegt, Klaas, Trapa, Patrick, McCarthy, Timothy J, Villalobos, Anabella, Halldin, Christer

“…Monoacylglycerol lipase (MAGL), a serine hydrolase extensively expressed throughout the brain, serves as a key gatekeeper regulating the tone of…”
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Seeding Specificity and Ultrastructural Characteristics of Infectious Recombinant Prions by Piro, Justin R, Wang, Fei, Walsh, Daniel J, Rees, Judy R, Ma, Jiyan, Supattapone, Surachai

“…Infectious mouse prions can be produced from a mixture of bacterially expressed recombinant prion protein (recPrP), palmitoyloleoylphosphatidylglycerol (POPG),…”
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Complex polyamines: unique prion disaggregating compounds by Supattapone, Surachai, Piro, Justin R, Rees, Judy R

“…Among the candidate anti-prion chemotherapeutic agents identified to date, complex polyamines constitute the only class of compounds that possess the ability…”
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Non-reducing alkaline solubilization and rapid on-column refolding of recombinant prion protein by Walsh, Daniel J., Noble, Geoffrey P., Piro, Justin R., Supattapone, Surachai

“…Mature prion protein (PrP) is a 208-residue polypeptide that contains a single disulfide bond. We report an alternative method to purify recombinant mouse PrP…”
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In Situ Photodegradation of Incorporated Polyanion Does Not Alter Prion Infectivity: e1002001 by Piro, Justin R, Harris, Brent T, Supattapone, Surachai

“…Single-stranded polyanions ≥40 bases in length facilitate the formation of hamster scrapie prions in vitro, and polyanions co-localize with PrPSc aggregates in…”
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Cofactor molecules maintain infectious conformation and restrict strain properties in purified prions by Deleault, Nathan R., Walsh, Daniel J., Piro, Justin R., Wang, Fei, Wang, Xinhe, Ma, Jiyan, Rees, Judy R., Supattapone, Surachai

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Biochemical and Biophysical Characterization of Prion Infectivity and Strain Properties by Piro, Justin R

“…The transmissible spongiform encephalopathies (TSEs) are a class of fatal neurodegenerative disorders that can affect animals or humans. The mechanisms of the…”
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Biochemical and Biophysical Characterization of Prion Infectivity and Strain Properties by Piro, Justin R

“…The transmissible spongiform encephalopathies (TSEs) are a class of fatal neurodegenerative disorders that can affect animals or humans. The mechanisms of the…”
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