Search Results - "Pirman, David"

Quantitative Tandem Mass Spectrometric Imaging of Endogenous Acetyl-l-carnitine from Piglet Brain Tissue Using an Internal Standard by Pirman, David A, Yost, Richard A

“…Matrix-assisted laser desorption/ionization (MALDI) based mass spectrometric imaging (MSI) is increasingly being used as an analytical tool to evaluate the…”
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Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase by Padyana, Anil K., Gross, Stefan, Jin, Lei, Cianchetta, Giovanni, Narayanaswamy, Rohini, Wang, Feng, Wang, Rui, Fang, Cheng, Lv, Xiaobing, Biller, Scott A., Dang, Lenny, Mahoney, Christopher E., Nagaraja, Nelamangala, Pirman, David, Sui, Zhihua, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

“…Squalene epoxidase (SQLE), also known as squalene monooxygenase, catalyzes the stereospecific conversion of squalene to 2,3( S )-oxidosqualene, a key step in…”
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Targeting hepatic glutaminase activity to ameliorate hyperglycemia by Miller, Russell A, Shi, Yuji, Lu, Wenyun, Pirman, David A, Jatkar, Aditi, Blatnik, Matthew, Wu, Hong, Cárdenas, César, Wan, Min, Foskett, J Kevin, Park, Junyoung O, Zhang, Yiyi, Holland, William L, Rabinowitz, Joshua D, Birnbaum, Morris J

“…In mice, elevated glucagon during type 2 diabetes promotes more hepatic glutamine flux and greater gluconeogenesis, while reducing glutamine metabolism in the…”
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Quantitative MALDI Tandem Mass Spectrometric Imaging of Cocaine from Brain Tissue with a Deuterated Internal Standard by Pirman, David A, Reich, Richard F, Kiss, András, Heeren, Ron M. A, Yost, Richard A

“…Mass spectrometric imaging (MSI) is an analytical technique used to determine the distribution of individual analytes within a given sample. A wide array of…”
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A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition by Mahoney, Christopher E., Pirman, David, Chubukov, Victor, Sleger, Taryn, Hayes, Sebastian, Fan, Zi Peng, Allen, Eric L., Chen, Ying, Huang, Lingling, Liu, Meina, Zhang, Yingjia, McDonald, Gabrielle, Narayanaswamy, Rohini, Choe, Sung, Chen, Yue, Gross, Stefan, Cianchetta, Giovanni, Padyana, Anil K., Murray, Stuart, Liu, Wei, Marks, Kevin M., Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Nagaraja, Nelamangala, Biller, Scott A., Roddy, Thomas, Popovici-Muller, Janeta, Smolen, Gromoslaw A.

“…Aberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging…”
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EGFR signaling promotes inflammation and cancer stem-like activity in inflammatory breast cancer by Wang, Xiaoping, Reyes, Monica E, Zhang, Dongwei, Funakoshi, Yohei, Trape, Adriana P, Gong, Yun, Kogawa, Takahiro, Eckhardt, Bedrich L, Masuda, Hiroko, Pirman, Jr, David A, Yang, Peiying, Reuben, James M, Woodward, Wendy A, Bartholomeusz, Chandra, Hortobagyi, Gabriel N, Tripathy, Debu, Ueno, Naoto T

“…Inflammatory breast cancer (IBC) is the most lethal and aggressive type of breast cancer, with a strong proclivity to metastasize, and IBC-specific targeted…”
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Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux by Masud, Sanna N., Chandrashekhar, Megha, Aregger, Michael, Tan, Guihong, Zhang, Xiaoyu, Mero, Patricia, Pirman, David A., Zaslaver, Olga, Smolen, Gromoslaw A., Lin, Zhen-Yuan, Wong, Cassandra J., Boone, Charles, Gingras, Anne-Claude, Montenegro-Burke, J. Rafael, Moffat, Jason

“…Pyrvinium is a quinoline-derived cyanine dye and an approved anti-helminthic drug reported to inhibit WNT signaling and have anti-proliferative effects in…”
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Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry by Pirman, David A, Efuet, Ekem, Ding, Xiao-Ping, Pan, Yong, Tan, Lin, Fischer, Susan M, DuBois, Raymond N, Yang, Peiying

“…Biomarker discovery using mass spectrometry (MS) has recently seen a significant increase in applications, mainly driven by the rapidly advancing field of…”
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Identifying Tissue-Specific Signal Variation in MALDI Mass Spectrometric Imaging by Use of an Internal Standard by Pirman, David A, Kiss, András, Heeren, Ron M. A, Yost, Richard A

“…Generating analyte-specific distribution maps of compounds in a tissue sample by matrix-assisted laser desorption/ionization (MALDI) mass spectrometric imaging…”
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Author Correction: Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux by Masud, Sanna N., Chandrashekhar, Megha, Aregger, Michael, Tan, Guihong, Zhang, Xiaoyu, Mero, Patricia, Pirman, David A., Zaslaver, Olga, Smolen, Gromoslaw A., Lin, Zhen-Yuan, Wong, Cassandra J., Boone, Charles, Gingras, Anne-Claude, Montenegro-Burke, J. Rafael, Moffat, Jason

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Differential Aspartate Usage Identifies a Subset of Cancer Cells Particularly Dependent on OGDH by Allen, Eric L., Ulanet, Danielle B., Pirman, David, Mahoney, Christopher E., Coco, John, Si, Yaguang, Chen, Ying, Huang, Lingling, Ren, Jinmin, Choe, Sung, Clasquin, Michelle F., Artin, Erin, Fan, Zi Peng, Cianchetta, Giovanni, Murtie, Joshua, Dorsch, Marion, Jin, Shengfang, Smolen, Gromoslaw A.

“…Although aberrant metabolism in tumors has been well described, the identification of cancer subsets with particular metabolic vulnerabilities has remained…”
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Phenotyping hepatocellular metabolism using uniformly labeled carbon-13 molecular probes and LC-HRMS stable isotope tracing by Meissen, John K., Pirman, David A., Wan, Min, Miller, Emily, Jatkar, Aditi, Miller, Russell, Steenwyk, Rick C., Blatnik, Matthew

“…Metabolite stable isotope tracing is a powerful bioanalytical strategy that has the potential to unravel phenotypic markers of early pharmaceutical efficacy by…”
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Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia by Miller, Russell A., Shi, Yuji, Lu, Wenyun, Pirman, David A., Jatkar, Aditi, Blatnik, Matthew, Wu, Hong, Cárdenas, César, Wan, Min, Foskett, J. Kevin, Park, Junyoung O., Zhang, Yiyi, Holland, William L., Rabinowitz, Joshua D., Birnbaum, Morris J.

“…In the version of this article initially published, the “[13C2]α-ketoglutarate” label on Fig. 1g is incorrect. It should be “[13C5]α-ketoglutarate”…”
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Quantitative profiling of tissue drug distribution by MS imaging by Pirman, David

“…This article highlights recent advancements in the quantitative measurement of drug distribution by MS imaging (MSI). Quantitation by MSI was recently…”
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Plasma concentration and local anesthetic activity of procaine hydrochloride following subcutaneous administration to horses by Kuchembuck, N.L, Colahan, P.T, Zientek, K.D, Pirman, D.A, Wegner, K, Cole, C.A

“…To determine the durations of the local anesthetic effect and plasma procaine concentrations associated with 5- and 10-mg doses of procaine hydrochloride (with…”
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Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer by Best, Sarah A., Gubser, Patrick M., Sethumadhavan, Shalini, Kersbergen, Ariena, Negrón Abril, Yashira L., Goldford, Joshua, Sellers, Katherine, Abeysekera, Waruni, Garnham, Alexandra L., McDonald, Jackson A., Weeden, Clare E., Anderson, Dovile, Pirman, David, Roddy, Thomas P., Creek, Darren J., Kallies, Axel, Kingsbury, Gillian, Sutherland, Kate D.

“…The tumor microenvironment (TME) contains a rich source of nutrients that sustains cell growth and facilitate tumor development. Glucose and glutamine in the…”
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Quantitative tandem mass spectrometric imaging with matrix-assisted laser desorption/ionization by Pirman, David Andrew

“…Mass spectrometric imaging (MSI) allows for direct analysis of tissues by matrix-assisted laser desorption/ionization (MALDI) tandem mass spectrometry (MSn or…”
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BHV-2100, a First-in-class TRPM3 Antagonist for the Treatment of Pain (S13.002) by Vriens, Joris, Vanherck, Jean-Christophe, Marchand, Arnaud, Carr, Bruce, Dubowchik, Gene, Caldwell, Reese, Granit, Volkan, Marcin, Lawrence, Pirman, David, Chaltin, Patrick, Voets, Thomas

“…Abstract only…”
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Novel Bispecific Degrader BHV-1300 Achieves Rapid, Robust, and Selective IgG Reduction in Preclinical Models Including Nonhuman Primates (S43.004) by Bunin, Anna, Lee, Seong, Kazmierski, Wes, McGrath, Kathleen, Rossi, Anne Marie, Nicholson, Simone, Dubowchik, Gene, Dierks, Elizabeth, Sharpe, Neal, Pirman, David, Car, Bruce, Qureshi, Irfan, Coric, Vladimir, Spiegel, David

“…Abstract only…”
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Metabolic analysis reveals evidence for branched chain amino acid catabolism crosstalk and the potential for improved treatment of organic acidurias by McCalley, Stephen, Pirman, David, Clasquin, Michelle, Johnson, Kendall, Jin, Shengfang, Vockley, Jerry

“…Branched chain amino acid (BCAA) metabolism occurs within the mitochondrial matrix and is comprised of multiple enzymes, some shared, organized into three…”
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