Search Results - "Piris, Adriano"

Toward Minimal Residual Disease-Directed Therapy in Melanoma by Rambow, Florian, Rogiers, Aljosja, Marin-Bejar, Oskar, Aibar, Sara, Femel, Julia, Dewaele, Michael, Karras, Panagiotis, Brown, Daniel, Chang, Young Hwan, Debiec-Rychter, Maria, Adriaens, Carmen, Radaelli, Enrico, Wolter, Pascal, Bechter, Oliver, Dummer, Reinhard, Levesque, Mitchell, Piris, Adriano, Frederick, Dennie T., Boland, Genevieve, Flaherty, Keith T., van den Oord, Joost, Voet, Thierry, Aerts, Stein, Lund, Amanda W., Marine, Jean-Christophe

“…Many patients with advanced cancers achieve dramatic responses to a panoply of therapeutics yet retain minimal residual disease (MRD), which ultimately results…”
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STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming by Chu, Zhaowei, Gu, Lei, Hu, Yeguang, Zhang, Xiaoyang, Li, Man, Chen, Jiajia, Teng, Da, Huang, Man, Shen, Che-Hung, Cai, Li, Yoshida, Toshimi, Qi, Yifeng, Niu, Zhixin, Feng, Austin, Geng, Songmei, Frederick, Dennie T., Specht, Emma, Piris, Adriano, Sullivan, Ryan J., Flaherty, Keith T., Boland, Genevieve M., Georgopoulos, Katia, Liu, David, Shi, Yang, Zheng, Bin

“…The cohesin complex participates in the organization of 3D genome through generating and maintaining DNA loops. Stromal antigen 2 (STAG2), a core subunit of…”
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Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids by Jenkins, Russell W, Aref, Amir R, Lizotte, Patrick H, Ivanova, Elena, Stinson, Susanna, Zhou, Chensheng W, Bowden, Michaela, Deng, Jiehui, Liu, Hongye, Miao, Diana, He, Meng Xiao, Walker, William, Zhang, Gao, Tian, Tian, Cheng, Chaoran, Wei, Zhi, Palakurthi, Sangeetha, Bittinger, Mark, Vitzthum, Hans, Kim, Jong Wook, Merlino, Ashley, Quinn, Max, Venkataramani, Chandrasekar, Kaplan, Joshua A, Portell, Andrew, Gokhale, Prafulla C, Phillips, Bart, Smart, Alicia, Rotem, Asaf, Jones, Robert E, Keogh, Lauren, Anguiano, Maria, Stapleton, Lance, Jia, Zhiheng, Barzily-Rokni, Michal, Cañadas, Israel, Thai, Tran C, Hammond, Marc R, Vlahos, Raven, Wang, Eric S, Zhang, Hua, Li, Shuai, Hanna, Glenn J, Huang, Wei, Hoang, Mai P, Piris, Adriano, Eliane, Jean-Pierre, Stemmer-Rachamimov, Anat O, Cameron, Lisa, Su, Mei-Ju, Shah, Parin, Izar, Benjamin, Thakuria, Manisha, LeBoeuf, Nicole R, Rabinowits, Guilherme, Gunda, Viswanath, Parangi, Sareh, Cleary, James M, Miller, Brian C, Kitajima, Shunsuke, Thummalapalli, Rohit, Miao, Benchun, Barbie, Thanh U, Sivathanu, Vivek, Wong, Joshua, Richards, William G, Bueno, Raphael, Yoon, Charles H, Miret, Juan, Herlyn, Meenhard, Garraway, Levi A, Van Allen, Eliezer M, Freeman, Gordon J, Kirschmeier, Paul T, Lorch, Jochen H, Ott, Patrick A, Hodi, F Stephen, Flaherty, Keith T, Kamm, Roger D, Boland, Genevieve M, Wong, Kwok-Kin, Dornan, David, Paweletz, Cloud Peter, Barbie, David A

“…systems that incorporate features of the tumor microenvironment and model the dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in…”
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RAS Mutations Are Associated With the Development of Cutaneous Squamous Cell Tumors in Patients Treated With RAF Inhibitors by OBERHOLZER, Patrick A, KEE, Damien, PIRIS, Adriano, MACCONAILL, Laura E, ROBERT, Caroline, HOFBAUER, Günther F. L, MCARTHUR, Grant A, SCHADENDORF, Dirk, GARRAWAY, Levi A, DZIUNYCZ, Piotr, SUCKER, Antje, KAMSUKOM, Nyam, JONES, Robert, RODEN, Christine, CHALK, Clinton J, ARDLIE, Kristin, PALESCANDOLO, Emanuele

“…RAF inhibitors are effective against melanomas with BRAF V600E mutations but may induce keratoacanthomas (KAs) and cutaneous squamous cell carcinomas (cSCCs)…”
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A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors by Konieczkowski, David J, Johannessen, Cory M, Abudayyeh, Omar, Kim, Jong Wook, Cooper, Zachary A, Piris, Adriano, Frederick, Dennie T, Barzily-Rokni, Michal, Straussman, Ravid, Haq, Rizwan, Fisher, David E, Mesirov, Jill P, Hahn, William C, Flaherty, Keith T, Wargo, Jennifer A, Tamayo, Pablo, Garraway, Levi A

“…Most melanomas harbor oncogenic BRAF(V600) mutations, which constitutively activate the MAPK pathway. Although MAPK pathway inhibitors show clinical benefit in…”
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Germline BAP1 inactivation is preferentially associated with metastatic ocular melanoma and cutaneous-ocular melanoma families by Njauw, Ching-Ni Jenny, Kim, Ivana, Piris, Adriano, Gabree, Michele, Taylor, Michael, Lane, Anne Marie, DeAngelis, Margaret M, Gragoudas, Evangelos, Duncan, Lyn M, Tsao, Hensin

“…BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation in a few individuals from…”
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Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma by Starrett, Gabriel J, Thakuria, Manisha, Chen, Tianqi, Marcelus, Christina, Cheng, Jingwei, Nomburg, Jason, Thorner, Aaron R, Slevin, Michael K, Powers, Winslow, Burns, Robert T, Perry, Caitlin, Piris, Adriano, Kuo, Frank C, Rabinowits, Guilherme, Giobbie-Hurder, Anita, MacConaill, Laura E, DeCaprio, James A

“…Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin caused by either the integration of Merkel cell polyomavirus (MCPyV)…”
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Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma by Shen, Che-Hung, Kim, Sun Hye, Trousil, Sebastian, Frederick, Dennie T, Piris, Adriano, Yuan, Ping, Cai, Li, Gu, Lei, Li, Man, Lee, Jung Hyun, Mitra, Devarati, Fisher, David E, Sullivan, Ryan J, Flaherty, Keith T, Zheng, Bin

“…Mutation or downregulation of cohesin components confer ERK reactivation and resistance to BRAF or MEK inhibitors in melanoma cells expressing BRAF or NRAS…”
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BAP1 and BRAFV600E expression in benign and malignant melanocytic proliferations by Piris, Adriano, MD, Mihm, Martin C., MD, Hoang, Mai P., MD

“…Summary BAP1 (BRCA1-associated protein 1) is a tumor suppressor gene whose mutations have recently been reported to increase susceptibility for the development…”
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In Memoriam—Martin C. Mihm, Jr by Kupper, Thomas, Piris, Adriano, Kroshinsky, Daniela, Kaya, Gürkan

“…Martin C [...]…”
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Cutaneous and mammary apocrine carcinomas have different immunoprofiles by Piris, Adriano, MD, Peng, Yan, MD, PhD, Boussahmain, Chakib, BS, Essary, Lydia R., MD, Gudewicz, Thomas M., MD, Hoang, Mai P., MD

“…Summary Often the distinction of cutaneous apocrine carcinoma from metastatic mammary apocrine carcinoma to the skin can be a diagnostic dilemma because both…”
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Dermal Granuloma Annulare After SARS-CoV-2 Vaccination: A Rare Complication by Tahir, Muhammad, Bodies, Belin F, Shalin, Sara, Phung, Thuy, Myers, Thomas C, Israel, Robert, Piris, Adriano, Knowles, Kurt

“…Granuloma annulare (GA) is an inflammatory granulomatous skin disease of unknown etiology that is self-limiting in nature. However, it is hypothesized that…”
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Increased diagnosis of thin superficial spreading melanomas: A 20-year study by Frangos, Jason E., MD, Duncan, Lyn M., MD, Piris, Adriano, MD, Nazarian, Rosalynn M., MD, Mihm, Martin C., MD, Hoang, Mai P., MD, Gleason, Briana, MD, Flotte, Thomas J., MD, Byers, Hugh R., MD, Barnhill, Raymond L., MD, Kimball, Alexa B., MD, MPH

“…Background Diagnostic practice by dermatopathologists evaluating pigmented lesions may have evolved over time. Objectives We sought to investigate diagnostic…”
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Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment by Friedman, Adam A, Amzallag, Arnaud, Pruteanu-Malinici, Iulian, Baniya, Subash, Cooper, Zachary A, Piris, Adriano, Hargreaves, Leeza, Igras, Vivien, Frederick, Dennie T, Lawrence, Donald P, Haber, Daniel A, Flaherty, Keith T, Wargo, Jennifer A, Ramaswamy, Sridhar, Benes, Cyril H, Fisher, David E

“…A newer generation of anti-cancer drugs targeting underlying somatic genetic driver events have resulted in high single-agent or single-pathway response rates…”
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Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation by Kim, Hyungsoo, Frederick, Dennie T., Levesque, Mitchell P., Cooper, Zachary A., Feng, Yongmei, Krepler, Clemens, Brill, Laurence, Samuels, Yardena, Hayward, Nicholas K., Perlina, Ally, Piris, Adriano, Zhang, Tongwu, Halaban, Ruth, Herlyn, Meenhard M., Brown, Kevin M., Wargo, Jennifer A., Dummer, Reinhard, Flaherty, Keith T., Ronai, Ze’ev A.

“…Despite the remarkable clinical response of melanoma harboring BRAF mutations to BRAF inhibitors (BRAFi), most tumors become resistant. Here, we identified the…”
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p40 exhibits better specificity than p63 in distinguishing primary skin adnexal carcinomas from cutaneous metastases by Lee, Jonathan J., BA, Mochel, Mark C., MD, Piris, Adriano, MD, Boussahmain, Chakib, BS, Mahalingam, Meera, MD, Hoang, Mai P., MD

“…Summary The histopathologic distinction between primary adnexal carcinomas and metastatic adenocarcinoma to the skin from sites such as the breast, lung, and…”
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Continuous Spatial Sequences of Lichen Sclerosus, Penile Intraepithelial Neoplasia, and Invasive Carcinomas: A Study of 109 Cases by Cañete-Portillo, Sofía, Sanchez, Diego F., Fernández-Nestosa, María José, Piris, Adriano, Zarza, Patricia, Oneto, Sabrina, Gonzalez Stark, Lorena, Lezcano, Cecilia, Ayala, Gustavo, Rodriguez, Ingrid, Hoang, Mai P., Mihm, Martin C., Cubilla, Antonio L.

“…Lichen sclerosus (LSc) with penile cancer is found in about two thirds of specimens. It has been hypothesized that LSc represents a precancerous condition. To…”
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Wolf isotopic response manifesting as postherpetic granuloma annulare: a case series by Kapoor, Roger, Piris, Adriano, Saavedra, Arturo P, Duncan, Lyn M, Nazarian, Rosalynn M

“…Wolf isotopic response has infrequently been reported in the literature, mainly as isolated case reports. To aid in recognition of the occurrence of…”
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Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors by Hung, Tawny, MD, Piris, Adriano, MD, Lobo, Alice, MD, Mihm, Martin C., MD, Sober, Arthur J., MD, Tsao, Hensin, MD, Tanabe, Kenneth K., MD, Duncan, Lyn M., MD

“…Summary The diagnosis and clinical management of spitzoid melanocytic tumors with atypical features remain problematic and controversial. In the past decade,…”
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Topographical Evaluation of Penile Lichen Sclerosus Reveals a Lymphocytic Depleted Variant, Preferentially Associated With Neoplasia: A Report of 200 Cases by Piris, Adriano, Sanchez, Diego F., Fernandez-Nestosa, Maria José, Cañete-Portillo, Sofía, Campagnoli, Tania, Gonzalez Stark, Lorena, Zarza, Patricia, Oneto, Sabrina, Lezcano, Cecilia, Rodriguez, Ingrid, Velazquez, Elsa F., Mihm, Martin, Cubilla, Antonio L.

“…Since the seminal study of Hart and Helwig in 1975, there are few detailed pathological studies of lichen sclerosus (LS). The aims of this study were to…”
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