Search Results - "Pirilä, L."

The validity of rheumatoid arthritis diagnoses in Finnish biobanks by Paltta, J, Heikkilä, H-K, Pirilä, L, Eklund, KK, Huhtakangas, J, Isomäki, P, Kaipiainen-Seppänen, O, Kristiansson, K, Havulinna, AS, Sokka-Isler, T, Palomäki, A

“…The aim of this study was to determine the validity of rheumatoid arthritis (RA) diagnoses in patients participating in Finnish biobanks. We reviewed the…”
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Pxmp2 is a channel-forming protein in Mammalian peroxisomal membrane by Rokka, Aare, Antonenkov, Vasily D, Soininen, Raija, Immonen, Hanna L, Pirilä, Päivi L, Bergmann, Ulrich, Sormunen, Raija T, Weckström, Matti, Benz, Roland, Hiltunen, J Kalervo

“…Peroxisomal metabolic machinery requires a continuous flow of organic and inorganic solutes across peroxisomal membrane. Concerning small solutes, the…”
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Drug survival on tumour necrosis factor inhibitors in patients with rheumatoid arthritis in Finland by Aaltonen, KJ, Joensuu, JT, Pirilä, L, Kauppi, M, Uutela, T, Varjolahti-Lehtinen, T, Yli-Kerttula, T, Isomäki, P, Nordström, D, Sokka, T

“…Objective: A systematic review found that an average of 27% of rheumatoid arthritis (RA) patients using tumour necrosis factor (TNF) inhibitors discontinue…”
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Immunogenicity of subcutaneous TNF inhibitors and its clinical significance in real-life setting in patients with spondyloarthritis by Hiltunen, J., Parmanne, P., Sokka, T., Lamberg, T., Isomäki, P., Kaipiainen-Seppänen, O., Peltomaa, R., Uutela, T., Pirilä, L., Taimen, K., Kauppi, M. J., Yli-Kerttula, T., Tuompo, R., Relas, H., Kortelainen, S., Paalanen, K., Asikainen, J., Ekman, P., Santisteban, A., Vidqvist, K.-L., Tadesse, K., Romu, M., Borodina, J., Elfving, P., Valleala, H., Leirisalo-Repo, M., Rantalaiho, V., Kautiainen, H., Jokiranta, T. S., Eklund, K. K.

“…Key messages Considerable proportion of patients with SpA have been immunized to the subcutaneous anti-TNF drug they are using. Concomitant use of MTX protects…”
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Three out of four disease-modifying anti-rheumatic drug-naïve rheumatoid arthritis patients meet 28-joint Disease Activity Score remission at 12 months: results from the FIN-ERA cohort by Rannio, T, Asikainen, J, Hannonen, P, Yli-Kerttula, T, Ekman, P, Pirilä, L, Kuusalo, L, Mali, M, Puurtinen-Vilkki, M, Kortelainen, S, Paltta, J, Taimen, K, Kauppi, M, Laiho, K, Nyrhinen, S, Mäkinen, H, Isomäki, P, Uotila, T, Aaltonen, K, Kautiainen, H, Sokka, T

“…Objective: To assess what proportion of patients with disease-modifying anti-rheumatic drug (DMARD)-naïve early rheumatoid arthritis (ERA) reach 28-joint…”
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Differential diagnostics of polymyalgia rheumatica in a university hospital in Finland by Paltta, J, Suuronen, S, Pirilä, L, Palomäki, A

“…Diagnosing polymyalgia rheumatica (PMR) can be difficult as many conditions present with similar symptoms and findings. This study aimed to analyse how often…”
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Systemic sclerosis: changes in the incidence rates in the Finnish population during the years 1999-2018 by Kortelainen, S, Käyrä, M, Hurme, S, Paltta, J, Pirilä, L, Huhtakangas, J

“…The aim of our study was to examine changes in the incidence of systemic sclerosis (SSc) in Finland using two different classification criteria. Medical…”
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Identical twins with statin-associated anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase autoantibody-positive autoimmune myopathy by Mali, M, Pirilä, L, Perander, L, Gardberg, M, Jokela, M

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Causes and predictors of death among Finnish patients with systemic sclerosis by Kortelainen, S, Käyrä, M, Rissanen, T, Paltta, J, Taimen, K, Pirilä, L, Huhtakangas, J

“…The aim of this study was to assess causes and predictors of death among Finnish patients with systemic sclerosis (SSc). Medical records of patients registered…”
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Real-world registry-based study on apremilast use in psoriasis and psoriatic arthritis in Finland by Koskivirta, I, Ruotsalainen, J, Kurki, S, Lakkakorpi, P, Salminen-Mankonen, H, Pirilä, L, Harvima, R, Palomäki, A

“…This study assessed the position of apremilast in the treatment pathway of psoriasis (PsO) and psoriatic arthritis (PsA) in Finnish clinical practice, compared…”
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The validity of systemic sclerosis diagnoses in two university hospitals in Finland by Paltta, J, Kortelainen, S, Käyrä, M, Pirilä, L, Huhtakangas, J, Palomäki, A

“…This study aimed to determine the validity of systemic sclerosis (SSc) diagnoses in Finnish university hospitals. Electronic medical records for 385 patients…”
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Syndecan-1 expression is upregulated in degenerating articular cartilage in a transgenic mouse model for osteoarthritis by Salminen-Mankonen, H., Säämänen, A. -. M., Jalkanen, M., Vuorio, E., Pirilä, L.

“…Objective: Mice heterozygous for the Del1 transgene locus with a short deletion mutation in the type II collagen gene develop early-onset degenerative changes…”
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Altered integrin expression in rheumatoid synovial lining type B cells: in vitro cytokine regulation of alpha 1 beta 1, alpha 6 beta 1, and alpha v beta 5 integrins by Pirilä, L, Heino, J

“…We recently showed that in rheumatoid arthritis (RA) the extracellular matrix around the lining cells is similar to the matrix seen in osteoarthritis, whereas…”
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Measuring the economic value of morning stiffness: consistency over 1 year by Tuominen, S, Leino, M, Pirilä, L, Tuominen, R

“…Objectives: The aims of this study were to determine the within-patient variation in the duration of morning stiffness (MS) over 1 year and the corresponding…”
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Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration by Ørnbjerg, Lykke M., Linde, Louise, Georgiadis, Stylianos, Rasmussen, Simon H., Lindström, Ulf, Askling, Johan, Michelsen, Brigitte, Giuseppe, Daniela Di, Wallman, Johan K., Pavelka, Karel, Závada, Jakub, Nissen, Michael J., Jones, Gareth T., Relas, Heikki, Pirilä, Laura, Tomšič, Matija, Rotar, Ziga, Geirsson, Arni Jon, Gudbjornsson, Bjorn, Kristianslund, Eirik K., van sder Horst-Bruinsma, Irene, Loft, Anne Gitte, Laas, Karin, Iannone, Florenzo, Corrado, Addolorata, Ciurea, Adrian, Santos, Maria J., Santos, Helena, Codreanu, Catalin, Akkoc, Nurullah, Gunduz, Ozgul S., Glintborg, Bente, Østergaard, Mikkel, Hetland, Merete Lund

“…In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline…”
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Bone Morphogenetic Protein-2 Is a Regulator of Cell Adhesion by Nissinen, Liisa, Pirilä, Laura, Heino, Jyrki

“…Bone morphogenetic proteins (BMPs) are a group of peptide growth factors closely related to transforming growth factors-β. The BMPs are suggested to play an…”
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Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase:  The Importance of Potassium and Chloride Ions for Its Structure and Function by Haapalainen, Antti M, Meriläinen, Gitte, Pirilä, Päivi L, Kondo, Naomi, Fukao, Toshiyuki, Wierenga, Rik K

“…Thiolases are CoA-dependent enzymes which catalyze the formation of a carbon−carbon bond in a Claisen condensation step and its reverse reaction via a…”
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ONCOPROTEIN EXPRESSION IN HUMAN SYNOVIAL TISSUE: AN IMMUNOHISTOCHEMICAL STUDY OF DIFFERENT TYPES OF ARTHRITIS by ROIVAINEN, A., SÖDERSTRÖM, K.-O., PERILÄ, L., ARO, H., KORTEKANGAS, P., MERILAHTI-PALO, R., YLI-JAMA, T., TOIVANEN, A., TOIVANEN, P.

“…Based on the fact that synovial lining cells have some properties of transformed-appearing cells, we have examined the expression of Myc, Myb, Fos, Jun and Ras…”
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Expression of laminins and their integrin receptors in different conditions of synovial membrane and synovial membrane-like interface tissue by Konttinen, Yrjö T, Li, Tian Fang, Xu, Jing Wen, Tagaki, Mickiaki, Pirilä, Laura, Silvennoinen, Timo, Santavirta, Seppo, Virtanen, Ismo

“…OBJECTIVE To demonstrate the expression of laminins (Lns) and their integrin (Int) receptors in different synovial samples and synovial membrane-like interface…”
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Organization of the multifunctional enzyme type 1: interaction between N- and C-terminal domains is required for the hydratase-1/isomerase activity by Kiema, Tiila-Riikka, Taskinen, Jukka P, Pirilä, Päivi L, Koivuranta, Kari T, Wierenga, Rik K, Hiltunen, J Kalervo

“…Rat peroxisomal multifunctional enzyme type 1 (perMFE-1) is a monomeric protein of beta-oxidation. We have defined five functional domains (A, B, C, D and E)…”
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