Sustained clearance of Mansonella ozzardi infection after treatment with ivermectin in the Brazilian Amazon

Sustained clearance of Mansonella ozzardi infection after treatment with ivermectin in the Brazilian Amazon

Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 7...

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Published in:The American journal of tropical medicine and hygiene Vol. 90; no. 6; pp. 1170 - 1175
Main Authors: Basano, Sergio de Almeida, Fontes, Gilberto, Medeiros, Jansen Fernandes, Aranha Camargo, Juliana Souza de Almeida, Souza Vera, Luana Janaína, Parente Araújo, Marcos Paulo, Pires Parente, Maira Santiago, Mattos Ferreira, Ricardo de Godoi, Barreto Crispim, Pedro di Tárique, Aranha Camargo, Luís Marcelo
Format: Journal Article
Language:English
Published: United States The American Society of Tropical Medicine and Hygiene 01-06-2014
Subjects:
Adolescent
Adult
Animals
Antiparasitic Agents - therapeutic use
Brazil
Child
Child, Preschool
Female
Hematologic Tests
Humans
Ivermectin - therapeutic use
Male
Mansonella - drug effects
Mansonella ozzardi
Mansonelliasis - drug therapy
Microfilariae
Middle Aged
Parasitemia
Rural Population
Treatment Outcome
Young Adult
Brazil
Brazil, Amazonas
South America, Amazon R
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Summary:Therapy for mansonelliasis is challenging because there is no standard drug recommended for its treatment. This non-randomized study was conducted to evaluate the effectiveness of a single dose of 0.15 mg/kg of ivermectin to reduce Mansonella ozzardi microfilaraemia in infected persons. A total of 74 patients were studied within the municipality of Lábrea, which is located in Amazonas State, Brazil. The patients were treated with ivermectin after detection of the parasite by blood examination. Significant microfilaraemia reduction was observed and its residual effect was maintained for at least 12 months. There was no significant change in the laboratory blood count, hepatic metabolites, and nitrogen-bounding compound excreta dosage values that could compromise the use of this drug, demonstrating that ivermectin has a low toxicity level.
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Authors' addresses: Sergio de Almeida Basano, Secretaria de Saúde do Estado de Rondônia, Porto Velho, Rondônia, Brazil, and Faculdade São Lucas, Departamento de Medicina, Porto Velho, Rondônia, Brazil, E-mail: sergio@icbusp.org. Gilberto Fontes, Universidade Federal de São João Del Rei, Divinópolis, Minas Gerais, Brazil, E-mail: gilberto.fontes@pq.cnpq.br. Jansen Fernandes Medeiros and Ricardo de Godoi Mattos Ferreira, Fundação Oswaldo Cruz, Fiocruz-Rondônia, Porto Velho, Rondônia, Brazil, E-mails: jmedeiro@gmail.com and ricardogodoi@fiocruz.br. Juliana Souza de Almeida Aranha Camargo, Luana Janaína Souza Vera, Marcos Paulo Parente Araújo, and Maira Santiago Pires Parente, Faculdade São Lucas, Porto Velho, Rondônia, Brazil, E-mails: juliana@icbusp.org, janaina@icbusp.org, marcos_medppa@hotmail.com, and maira_s_pires@hotmail.com. Pedro di Tárique Barreto Crispim, Universidade Federal de Rondônia, Porto Velho, Rondônia, Brazil. Luís Marcelo Aranha Camargo, Faculdade São Lucas, Departamento de Medicina, Porto Velho, Rondônia, Brasil, and Departamento de Parasitologia, Instituto de Ciências Biomédicas 5, Universidade de São Paulo, São Paulo, Brazil, E-mail: spider@icbusp.org.
Financial support: This study was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (grant no. 2008/10817-6).
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.13-0410