Dereplication of polar extracts from Croton antisyphiliticus Mart. roots and its anti-inflammatory and antinociceptive potential

Croton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs....

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Published in:	Natural product research Vol. 38; no. 12; pp. 2118 - 2122
Main Authors:	Simão, Jorge Luiz Souza, Prado, Stephanie Vilela, Pereira, Alana Kelyene, Alexandre, Gerso Pereira, Pires Gomide, Núbia Alves Mariano Teixeira, Matos da Silva, Marcia, Almeida, Dionys de Souza, Martins, Aline Nazareth, Bueno da Silva, Daiany Priscilla, Costa, Elson Alves da, Pasqualotto Severino, Vanessa Gisele
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 17-06-2024 Taylor & Francis Ltd
Subjects:	Analgesics - chemistry Analgesics - isolation & purification Analgesics - pharmacology Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Biological activity Brazil Carrageenan Cell migration chemistry Chromatography, High Pressure Liquid Croton - chemistry Croton genus Dexamethasone Drug development Drugs Edema Edema - chemically induced Edema - drug therapy endogenous mediators feature based molecular networking Indomethacin Inflammation Liquid chromatography Male Medicinal plants Mice Molecular Structure myeloperoxidase natural products Pain - chemically induced Pain - drug therapy Pain perception Peroxidase phenolic compounds Physical sciences Plant Extracts - chemistry Plant Extracts - pharmacology Plant Roots - chemistry Polyphenols Roots Brazil chemistry natural products Croton genus Physical sciences phenolic compounds myeloperoxidase feature based molecular networking endogenous mediators
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Summary:	Croton antisyphiliticus Mart. is a plant popularly used in folk medicine by traditional communities from Brazilian savannah to treat general inflammation. According to ethnopharmacological data, this specie can be considered a source of biologically active molecules for the development of new drugs. Thereby, this study reports the results of the dereplication approach of C. antisyphiliticus roots extracts and the in vivo evaluation of its potential antinociceptive and anti-inflammatory in albino Swiss mice. Based on HPLC coupled to Q-Exactive Orbitrap Mass Spectrometer and using GNPS, a total of thirteen polyphenolic compounds were noticed, including four compounds that have been reported for the first time in the genus Croton. Ethanolic and aqueous roots extracts demonstrated a dose-dependent inhibition for the number of writes, reduced pain induced by formalin and hyperalgesia induced by carrageenan. These extracts also reduced paw edema, cell migration, and myeloperoxidase activity, with effects similar to indomethacin and dexamethasone drugs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1478-6419 1478-6427
DOI:	10.1080/14786419.2023.2233672