Search Results - "Pires, Virginia M. R."

Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin-dockerin interaction by Bule, Pedro, Pires, Virgínia M. R., Alves, Victor D., Carvalho, Ana Luísa, Prates, José A. M., Ferreira, Luís M. A., Smith, Steven P., Gilbert, Harry J., Noach, Ilit, Bayer, Edward A., Najmudin, Shabir, Fontes, Carlos M. G. A.

“…Cellulosomes are highly sophisticated molecular nanomachines that participate in the deconstruction of complex polysaccharides, notably cellulose and…”
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Medical Grade Honey as a Promising Treatment to Improve Ovarian Tissue Transplantation by Azevedo, Ana Rita, Pais, Ana Sofia, Almeida-Santos, Teresa, Pires, Virgínia M R, Pessa, Pedro, Marques, Carla C, Nolasco, Sofia, Castelo-Branco, Pedro, Prates, José A M, Lopes-da-Costa, Luís, Laranjo, Mafalda, Botelho, Maria Filomena, Pereira, Rosa M L N, Pimenta, Jorge M B G A

“…Ovarian tissue cryopreservation is a female fertility preservation technique that presents major challenges for the maintenance of follicular viability after…”
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The active site of a carbohydrate esterase displays divergent catalytic and noncatalytic binding functions by Montanier, Cedric, Money, Victoria A, Pires, Virginia M R, Flint, James E, Pinheiro, Benedita A, Goyal, Arun, Prates, José A M, Izumi, Atsushi, Stålbrand, Henrik, Morland, Carl, Cartmell, Alan, Kolenova, Katarina, Topakas, Evangelos, Dodson, Eleanor J, Bolam, David N, Davies, Gideon J, Fontes, Carlos M G A, Gilbert, Harry J

“…Multifunctional proteins, which play a critical role in many biological processes, have typically evolved through the recruitment of different domains that…”
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Genetic Background and Diet Impact Beef Fatty Acid Composition and Stearoyl-CoA Desaturase mRNA Expression by Costa, Ana S. H., Silva, Marta P., Alfaia, Cristina P. M., Pires, Virgínia M. R., Fontes, Carlos M. G. A., Bessa, Rui J. B., Prates, José A. M.

“…The intramuscular fat composition of ruminant meats influences the quality of the final product, which explains the increasing interest in assessing the fatty…”
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Novel anti‐adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3‐L1 adipocytes by Martins, Susana V., Pires, Virgínia M. R., Madeira, Ana P., Nascimento, Mafalda, Alfaia, Cristina M., Castro, Matilde F., Soveral, Graça, Prates, José A.M., Lopes, Paula A.

“…In this study, we hypothesized that trans(t)8,cis(c)10 conjugated linoleic acid (CLA) isomer possesses anti‐adipogenic properties in resemblance to its…”
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Combined effects of dietary arginine, leucine and protein levels on fatty acid composition and gene expression in the muscle and subcutaneous adipose tissue of crossbred pigs by Madeira, Marta S., Pires, Virgínia M. R., Alfaia, Cristina M., Luxton, Richard, Doran, Olena, Bessa, Rui J. B., Prates, José A. M.

“…The cumulative effects of dietary arginine, leucine and protein levels on fat content, fatty acid composition and mRNA levels of genes controlling lipid…”
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Restriction of dietary protein does not promote hepatic lipogenesis in lean or fatty pigs by Madeira, Marta S., Pires, Virgínia M. R., Alfaia, Cristina M., Lopes, Paula A., Martins, Susana V., Pinto, Rui M. A., Prates, José A. M.

“…The influence of genotype (lean v. fatty) and dietary protein level (normal v. reduced) on plasma metabolites, hepatic fatty acid composition and mRNA levels…”
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Complexity of the Ruminococcus flavefaciens cellulosome reflects an expansion in glycan recognition by Venditto, Immacolata, Luis, Ana S., Rydahl, Maja, Schückel, Julia, Fernandes, Vânia O., Vidal-Melgosa, Silvia, Bule, Pedro, Goyal, Arun, Pires, Virginia M. R., Dourado, Catarina G., Ferreira, Luís M. A., Coutinho, Pedro M., Henrissat, Bernard, Knox, J. Paul, Baslé, Arnaud, Najmudin, Shabir, Gilbert, Harry J., Willats, William G. T., Fontes, Carlos M. G. A.

“…The breakdown of plant cell wall (PCW) glycans is an important biological and industrial process. Noncatalytic carbohydrate binding modules (CBMs) fulfill a…”
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Novel insights into the degradation of β-1,3-glucans by the cellulosome of Clostridium thermocellum revealed by structure and function studies of a family 81 glycoside hydrolase by Kumar, Krishan, Correia, Márcia A.S., Pires, Virgínia M.R., Dhillon, Arun, Sharma, Kedar, Rajulapati, Vikky, Fontes, Carlos M.G.A., Carvalho, Ana Luísa, Goyal, Arun

“…The family 81 glycoside hydrolase (GH81) from Clostridium thermocellum is a β-1,3-glucanase belonging to cellulosomal complex. The gene encoding GH81 from…”
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Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis by Pimenta, Jorge M.B.G.A., Pires, Virgínia M.R., Nolasco, Sofia, Castelo-Branco, Pedro, Marques, Carla C., Apolónio, Joana, Azevedo, Rita, Fernandes, Mónica T., Lopes-da-Costa, Luís, Prates, José, Pereira, Rosa M.L.N.

“…Prion proteins constitute a major public health concern, which has partly overshadowed their physiological roles in several scenarios. Indeed, these proteins…”
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Differential effects of reduced protein diets on fatty acid composition and gene expression in muscle and subcutaneous adipose tissue of Alentejana purebred and Large White × Landrace × Pietrain crossbred pigs by Madeira, Marta S., Pires, Virgínia M. R., Alfaia, Cristina M., Costa, Ana S. H., Luxton, Richard, Doran, Olena, Bessa, Rui J. B., Prates, José A. M.

“…The present study assessed the effect of pig genotype (fatty v. lean) and dietary protein and lysine (Lys) levels (normal v. reduced) on intramuscular fat…”
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Adipocyte membrane glycerol permeability is involved in the anti-adipogenic effect of conjugated linoleic acid by Martins, Susana V., Madeira, Ana, Lopes, Paula A., Pires, Virgínia M.R., Alfaia, Cristina M., Prates, José A.M., Moura, Teresa, Soveral, Graça

“…Conjugated linoleic acid (CLA), a group of minor fatty acids from ruminant origin, has long been recognized as a body fat lowering agent. Given the…”
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Molecular Cloning, Expression and Biochemical Characterization of a Family 5 Glycoside Hydrolase First Endo-Mannanase (RfGH5_7) from Ruminococcus flavefaciens FD-1 v3 by Goyal, Dishant, Kumar, Krishan, Centeno, Maria S. J., Thakur, Abhijeet, Pires, Virgínia M. R., Bule, Pedro, Fontes, Carlos M. G. A., Goyal, Arun

“…The cellulosomal enzyme, Rf GH5 1/2 , of Ruminococcus flavefaciens contains an N-terminal module, a family 5 glycoside hydrolase GH5_4 with a putative…”
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Diverse specificity of cellulosome attachment to the bacterial cell surface by Brás, Joana L. A., Pinheiro, Benedita A., Cameron, Kate, Cuskin, Fiona, Viegas, Aldino, Najmudin, Shabir, Bule, Pedro, Pires, Virginia M. R., Romão, Maria João, Bayer, Edward A., Spencer, Holly L., Smith, Steven, Gilbert, Harry J., Alves, Victor D., Carvalho, Ana Luísa, Fontes, Carlos M. G. A.

“…During the course of evolution, the cellulosome, one of Nature’s most intricate multi-enzyme complexes, has been continuously fine-tuned to efficiently…”
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Betaine and arginine supplementation of low protein diets improves plasma lipids but does not affect hepatic fatty acid composition and related gene expression profiling in pigs by Madeira, Marta S, Rolo, Eva A, Lopes, Paula A, Ramos, Denis A, Alfaia, Cristina M, Pires, Virgínia MR, Martins, Susana V, Pinto, Rui MA, Prates, José AM

“…BACKGROUND The individual and combined effects of betaine and arginine supplemented to reduced protein diets were investigated on plasma metabolites, hepatic…”
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The family 11 carbohydrate-binding module of Clostridium thermocellum Lic26A-Cel5E accommodates beta-1,4- and beta-1,3-1,4-mixed linked glucans at a single binding site by Carvalho, Ana L, Goyal, Arun, Prates, José A M, Bolam, David N, Gilbert, Harry J, Pires, Virgínia M R, Ferreira, Luís M A, Planas, Antoni, Romão, Maria J, Fontes, Carlos M G A

“…Modular glycoside hydrolases that attack recalcitrant polymers generally contain noncatalytic carbohydrate-binding modules (CBMs), which play a critical role…”
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Molecular basis for the preferential recognition of β1,3‐1,4‐glucans by the family 11 carbohydrate‐binding module from Clostridium thermocellum by Ribeiro, Diana O., Viegas, Aldino, Pires, Virgínia M. R., Medeiros‐Silva, João, Bule, Pedro, Chai, Wengang, Marcelo, Filipa, Fontes, Carlos M. G. A., Cabrita, Eurico J., Palma, Angelina S., Carvalho, Ana Luísa

“…Understanding the specific molecular interactions between proteins and β1,3‐1,4‐mixed‐linked d‐glucans is fundamental to harvest the full biological and…”
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Cellulosome assembly: paradigms are meant to be broken by Bule, Pedro, Pires, Virgínia MR, Fontes, Carlos MGA, Alves, Victor D

“…Cohesin–Dockerin interactions are at the core of cellulosomal assembly and organization. They are highly specific and form stable complexes, allowing…”
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Stability and Ligand Promiscuity of Type A Carbohydrate-binding Modules Are Illustrated by the Structure of Spirochaeta thermophila StCBM64C by Pires, Virgínia M.R., Pereira, Pedro M.M., Brás, Joana L.A., Correia, Márcia, Cardoso, Vânia, Bule, Pedro, Alves, Victor D., Najmudin, Shabir, Venditto, Immacolata, Ferreira, Luís M.A., Romão, Maria João, Carvalho, Ana Luísa, Fontes, Carlos M.G.A., Prazeres, Duarte Miguel

“…Deconstruction of cellulose, the most abundant plant cell wall polysaccharide, requires the cooperative activity of a large repertoire of microbial enzymes…”
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Family 6 carbohydrate-binding modules display multiple β1,3-linked glucan-specific binding interfaces by Correia, Márcia A.S, Pires, Virgínia M.R, Gilbert, Harry J, Bolam, David N, Fernandes, Vânia O, Alves, Victor D, Prates, José A.M, Ferreira, Luís M.A, Fontes, Carlos M.G.A

“…Noncatalytic carbohydrate-binding modules (CBMs), which are found in a variety of carbohydrate-degrading enzymes, have been grouped into sequence-based…”
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