Search Results - "Piras, Bryan A"

Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway by French, Brent A., Kron, Irving L., Piras, Bryan A., Tian, Yikui, Yang, Zequan

“…Background. Activation of the adenosine A2B receptor (A2BR) can reduce myocardial ischemia/reperfusion (IR) injury. However, the mechanism underlying the…”
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Systemic delivery of shRNA by AAV9 provides highly efficient knockdown of ubiquitously expressed GFP in mouse heart, but not liver by Piras, Bryan A, O'Connor, Daniel M, French, Brent A

“…AAV9 is a powerful gene delivery vehicle capable of providing long-term gene expression in a variety of cell types, particularly cardiomyocytes. The use of…”
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Development and Optimization of a Hydrophobic Interaction Chromatography-Based Method of AAV Harvest, Capture, and Recovery by McNally, David J., Piras, Bryan A., Willis, Catherine M., Lockey, Timothy D., Meagher, Michael M.

“…With many ongoing clinical trials utilizing adeno-associated virus (AAV) gene therapy, it is necessary to find scalable and serotype-independent primary…”
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Increased survival of muscle stem cells lacking the MyoD gene after transplantation into regenerating skeletal muscle by Asakura, Atsushi, Hirai, Hiroyuki, Kablar, Boris, Morita, Shigeru, Ishibashi, Jeff, Piras, Bryan A, Christ, Amanda J, Verma, Mayank, Vineretsky, Karin A, Rudnicki, Michael A

“…MyoD is a myogenic master transcription factor that plays an essential role in muscle satellite cell (muscle stem cell) differentiation. To further investigate…”
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T2-weighted MRI of post-infarct myocardial edema in mice by Beyers, Ronald J., Smith, R. Scott, Xu, Yaqin, Piras, Bryan A., Salerno, Michael, Berr, Stuart S., Meyer, Craig H., Kramer, Christopher M., French, Brent A., Epstein, Frederick H.

“…T2‐weighted, cardiac magnetic resonance imaging (T2w CMR) can be used to noninvasively detect and quantify the edematous region that corresponds to the area at…”
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Heart Rate Reduction With Ivabradine Protects Against Left Ventricular Remodeling by Attenuating Infarct Expansion and Preserving Remote‐Zone Contractile Function and Synchrony in a Mouse Model of Reperfused Myocardial Infarction by O'Connor, Daniel M., Smith, Robert S., Piras, Bryan A., Beyers, Ronald J., Lin, Dan, Hossack, John A., French, Brent A.

“…Background Ivabradine selectively inhibits the pacemaker current of the sinoatrial node, slowing heart rate. Few studies have examined the effects of…”
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Increased angiogenesis and improved left ventricular function after transplantation of myoblasts lacking the MyoD gene into infarcted myocardium by Nakamura, Yasuhiro, Asakura, Yoko, Piras, Bryan A, Hirai, Hiroyuki, Tastad, Christopher T, Verma, Mayank, Christ, Amanda J, Zhang, Jianyi, Yamazaki, Takanori, Yoshiyama, Minoru, Asakura, Atsushi

“…Skeletal myoblast transplantation has therapeutic potential for repairing damaged heart. However, the optimal conditions for this transplantation are still…”
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Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector by Piras, Bryan A, Drury, Jason E, Morton, Christopher L, Spence, Yunyu, Lockey, Timothy D, Nathwani, Amit C, Davidoff, Andrew M, Meagher, Michael M

“…With clinical trials ongoing, efficient clinical production of adeno-associated virus (AAV) to treat large numbers of patients remains a challenge. We compared…”
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The cost-effectiveness of gene therapy for severe hemophilia B: a microsimulation study from the United States perspective by Bolous, Nancy S., Chen, Yichen, Wang, Huiqi, Davidoff, Andrew M., Devidas, Meenakshi, Jacobs, Timothy W., Meagher, Michael M., Nathwani, Amit C., Neufeld, Ellis J., Piras, Bryan A., Rodriguez-Galindo, Carlos, Reiss, Ulrike M., Bhakta, Nickhill

“…Adeno-associated virus (AAV)-mediated gene therapy is a novel treatment promising to reduce morbidity associated with hemophilia. Although multiple clinical…”
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Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis(®) Fixed-Bed Bioreactor by Powers, Alicia D, Piras, Bryan A, Clark, Robert K, Lockey, Timothy D, Meagher, Michael M

“…Adeno-associated virus (AAV) vectors are increasingly popular in gene therapy because they are unassociated with human disease, replication dependent, and less…”
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Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling by Konkalmatt, Prasad R., Wang, Feng, Piras, Bryan A., Xu, Yaqin, O'Connor, Daniel M., Beyers, Ronald J., Epstein, Frederick H., Annex, Brian H., Hossack, John A., French, Brent A.

“…Background Adeno‐associated virus serotype 9 (AAV9) vectors provide efficient and uniform gene expression to normal myocardium following systemic…”
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A novel cardiac muscle‐derived biomaterial reduces dyskinesia and postinfarct left ventricular remodeling in a mouse model of myocardial infarction by O'Connor, Daniel M., Naresh, Nivedita K., Piras, Bryan A., Xu, Yaqin, Smith, Robert S., Epstein, Frederick H., Hossack, John A., Ogle, Roy C., French, Brent A.

“…Extracellular matrix (ECM) degradation after myocardial infarction (MI) leaves the myocardium structurally weakened and, as a result, susceptible to early…”
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Abstract 14698: Self-Complementary AAV9 Provides No Advantage Over Single-Stranded AAV9 in shRNA Knockdown of Ubiquitously Expressed GFP in Heart or Liver after Systemic Delivery by Piras, Bryan A, French, Brent A

“…Abstract only Introduction: AAV9 is a potent gene delivery system that has been shown to preferentially transduce the heart over other tissues. We previously…”
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100. Evaluation of Ion-Exchange Membranes for the Purification of AAV8 from Culture Media by Piras, Bryan A., McNally, David J., Lockey, Timothy D., Nathwani, Amit C., Meagher, Michael M.

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555. Distribution of AAV8 Particles in Cell Lysates and Supernatants Changes with Time and Is Dependent on the Vector Genome by Piras, Bryan A., Lockey, Timothy D., Davidoff, Andrew, Nienhuis, Arthur, d'Azzo, Alessandra, Nathwani, Amit, Meagher, Michael

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Abstract 16531: Acute Hyperglycemia Polarizes and Myocardial Infarction Amplifies Differential Profiles of Gene Expression in Circulating Leukocytes by Smith, Robert S, Piras, Bryan A, Farber, Charles R, Yang, Zequan, Kron, Irving L, French, Brent A

“…IntroductionAcute hyperglycemia during MI is associated with higher clinical mortality and increased infarct size in the mouse model of reperfused MI. We used…”
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Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery by Katwal, A B, Konkalmatt, P R, Piras, B A, Hazarika, S, Li, S S, John Lye, R, Sanders, J M, Ferrante, E A, Yan, Z, Annex, B H, French, B A

“…Targeting therapeutic gene expression to the skeletal muscle following intravenous (IV) administration is an attractive strategy for treating peripheral…”
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T 2 ‐weighted MRI of post‐infarct myocardial edema in mice by Beyers, Ronald J., Smith, R. Scott, Xu, Yaqin, Piras, Bryan A., Salerno, Michael, Berr, Stuart S., Meyer, Craig H., Kramer, Christopher M., French, Brent A., Epstein, Frederick H.

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T2-weighted MRI of post-infarct myocardial edema in mice by Beyers, Ronald J., Smith, R. Scott, Xu, Yaqin, Piras, Bryan A., Salerno, Michael, Berr, Stuart S., Meyer, Craig H., Kramer, Christopher M., French, Brent A., Epstein, Frederick H.

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T 2 ‐weighted MRI of post‐infarct myocardial edema in mice by Beyers, Ronald J., Smith, R. Scott, Xu, Yaqin, Piras, Bryan A., Salerno, Michael, Berr, Stuart S., Meyer, Craig H., Kramer, Christopher M., French, Brent A., Epstein, Frederick H.

“…Abstract T 2 ‐weighted, cardiac magnetic resonance imaging ( T 2 w CMR) can be used to noninvasively detect and quantify the edematous region that corresponds…”
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