Bacillus toyonensis improves immune response in the mice vaccinated with recombinant antigen of bovine herpesvirus type 5

Probiotics modulate the immune response and can increase the effectiveness of vaccines. Bacillus toyonensis is widely used as a probiotic in animal feed. The aim of this study was to assess the effects of B. toyonensis administration on the immune response to an experimental recombinant vaccine agai...

Full description

Saved in:

Bibliographic Details
Published in:	Beneficial microbes Vol. 9; no. 1; p. 133
Main Authors:	Santos, F D S, Menegon, Y A, Piraine, R E A, Rodrigues, P R C, Cunha, R C, Leite, F P Leivas
Format:	Journal Article
Language:	English
Published:	Netherlands 29-01-2018
Subjects:	Animals Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Bacillus - immunology Cytokines - genetics Female Gene Expression Regulation - drug effects Herpesvirus 5, Bovine - immunology Herpesvirus Vaccines - administration & dosage Herpesvirus Vaccines - immunology Immunoglobulin G - blood Immunoglobulin G - immunology Immunologic Factors - administration & dosage Immunologic Factors - pharmacology Immunomodulation - drug effects Mice Probiotics - administration & dosage Probiotics - pharmacology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - immunology immunomodulation probiotic recombinant vaccine
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Probiotics modulate the immune response and can increase the effectiveness of vaccines. Bacillus toyonensis is widely used as a probiotic in animal feed. The aim of this study was to assess the effects of B. toyonensis administration on the immune response to an experimental recombinant vaccine against bovine herpesvirus type 5 (BoHV-5) in mice. Mice were vaccinated with BoHV-5 recombinant glycoprotein D and supplemented with the probiotic B. toyonensis in two regimes: one group received the probiotic only during seven days prior to the initial vaccination while the second group was given the probiotic throughout the experimental period of seven weeks. Animals supplemented with probiotic B. toyonensis in two regimes showed an increase in total immunoglobulin (Ig)G, IgG1 and IgG2a levels in serum, in addition to higher titres of antibodies capable of neutralising the BoHV-5 virus than non-supplemented animals (P<0.05). Splenocytes from the supplemented mice had higher mRNA transcription levels of cytokines interleukin (IL)-4 and IL-12. These results show that the use of this probiotic may significantly contribute to the response elicited by recombinant vaccines, especially those that rely on increasing antibody and cell-mediated immune responses for efficacy. Further, the data support an immunomodulatory effect for probiotic B. toyonensis and imply that enhance effect on the immune response against a BoHV-5 recombinant vaccine in mice.
ISSN:	1876-2891
DOI:	10.3920/BM2017.0021