Search Results - "Piper, Peter W."

Hog1 Mitogen-Activated Protein Kinase Phosphorylation Targets the Yeast Fps1 Aquaglyceroporin for Endocytosis, Thereby Rendering Cells Resistant to Acetic Acid by Mollapour, Mehdi, Piper, Peter W.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity by Mollapour, Mehdi, Tsutsumi, Shinji, Truman, Andrew W., Xu, Wanping, Vaughan, Cara K., Beebe, Kristin, Konstantinova, Anna, Vourganti, Srinivas, Panaretou, Barry, Piper, Peter W., Trepel, Jane B., Prodromou, Chrisostomos, Pearl, Laurence H., Neckers, Len

“…Heat shock protein 90 (Hsp90) is an essential molecular chaperone whose activity is regulated not only by cochaperones but also by distinct posttranslational…”
Get full text

Resistance of yeasts to weak organic acid food preservatives by Piper, Peter W

“…Carboxylate weak acids are invaluable for large-scale food and beverage preservation. However, in response to safety concerns, there is now desire to reduce…”
Get more information

Hsp90-Dependent Activation of Protein Kinases Is Regulated by Chaperone-Targeted Dephosphorylation of Cdc37 by Vaughan, Cara K., Mollapour, Mehdi, Smith, Jennifer R., Truman, Andrew, Hu, Bin, Good, Valerie M., Panaretou, Barry, Neckers, Len, Clarke, Paul A., Workman, Paul, Piper, Peter W., Prodromou, Chrisostomos, Pearl, Laurence H.

“…Activation of protein kinase clients by the Hsp90 system is mediated by the cochaperone protein Cdc37. Cdc37 requires phosphorylation at Ser13, but little is…”
Get full text

Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions by Meyer, Philippe, Prodromou, Chrisostomos, Hu, Bin, Vaughan, Cara, Roe, S. Mark, Panaretou, Barry, Piper, Peter W., Pearl, Laurence H.

“…Activation of client proteins by the Hsp90 molecular chaperone is dependent on binding and hydrolysis of ATP, which drives a molecular clamp via transient…”
Get full text

Potential Safety Issues Surrounding the Use of Benzoate Preservatives by Piper, Peter

“…Sodium benzoate (E211) and potassium sorbate (E202) have long been used for large-scale beverage preservation, yet it is potassium sorbate that is now the…”
Get full text

Co-chaperone Regulation of Conformational Switching in the Hsp90 ATPase Cycle by Siligardi, Giuliano, Hu, Bin, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H, Prodromou, Chrisostomos

“…ATP hydrolysis by the Hsp90 molecular chaperone requires a connected set of conformational switches triggered by ATP binding to the N-terminal domain in the…”
Get full text

Activation of the ATPase Activity of Hsp90 by the Stress-Regulated Cochaperone Aha1 by Panaretou, Barry, Siligardi, Giuliano, Meyer, Philippe, Maloney, Alison, Sullivan, Janis K., Singh, Shradha, Millson, Stefan H., Clarke, Paul A., Naaby-Hansen, Soren, Stein, Rob, Cramer, Rainer, Mollapour, Mehdi, Workman, Paul, Piper, Peter W., Pearl, Laurence H., Prodromou, Chrisostomos

“…Client protein activation by Hsp90 involves a plethora of cochaperones whose roles are poorly defined. A ubiquitous family of stress-regulated proteins have…”
Get full text

Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges by Piper, Peter W, Millson, Stefan H

“…The molecular chaperone Hsp90 holds great promise as a cancer drug target, despite some of the initial clinical trials of Hsp90 inhibitor drugs having not…”
Get full text

Novel stress responses facilitate Saccharomyces cerevisiae growth in the presence of the monocarboxylate preservatives by Mollapour, Mehdi, Shepherd, Andy, Piper, Peter W

“…Certain yeasts are relatively resistant to the small number of monocarboxylic acids allowed in food preservation, with the result that these preservatives…”
Get full text

Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery by Meyer, Philippe, Prodromou, Chrisostomos, Liao, Chunyan, Hu, Bin, Mark Roe, S, Vaughan, Cara K, Vlasic, Ignacija, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H

“…Hsp90 is a molecular chaperone essential for the activation and assembly of many key eukaryotic signalling and regulatory proteins. Hsp90 is assisted and…”
Get full text

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin by Roe, S. Mark, Prodromou, Chrisostomos, O'Brien, Ronan, Ladbury, John E, Piper, Peter W, Pearl, Laurence H

“…The cellular activity of several regulatory and signal transduction proteins, which depend on the Hsp90 molecular chaperone for folding, is markedly decreased…”
Get full text

A Two-Hybrid Screen of the Yeast Proteome for Hsp90 Interactors Uncovers a Novel Hsp90 Chaperone Requirement in the Activity of a Stress-Activated Mitogen-Activated Protein Kinase, Slt2p (Mpk1p) by Millson, Stefan H, Truman, Andrew W, King, Victoria, Prodromou, Chrisostomos, Pearl, Laurence H, Piper, Peter W

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Benzoate and Sorbate Salts: A Systematic Review of the Potential Hazards of These Invaluable Preservatives and the Expanding Spectrum of Clinical Uses for Sodium Benzoate by Piper, Joseph D., Piper, Peter W.

“…Sodium benzoate and potassium sorbate are extremely useful agents for food and beverage preservation, yet concerns remain over their complete safety. Benzoate…”
Get full text

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics by Piper, Peter W., Millson, Stefan H.

“…Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the…”
Get full text

Chaperone ligand-discrimination by the TPR-domain protein Tah1 by Millson, Stefan H, Vaughan, Cara K, Zhai, Chao, Ali, Maruf M U, Panaretou, Barry, Piper, Peter W, Pearl, Laurence H, Prodromou, Chrisostomos

“…Tah1 [TPR (tetratricopeptide repeat)-containing protein associated with Hsp (heat-shock protein) 90] has been identified as a TPR-domain protein. TPR-domain…”
Get more information

Expressed in the Yeast Saccharomyces cerevisiae, Human ERK5 Is a Client of the Hsp90 Chaperone That Complements Loss of the Slt2p (Mpk1p) Cell Integrity Stress-Activated Protein Kinase by Truman, Andrew W, Millson, Stefan H, Nuttall, James M, King, Victoria, Mollapour, Mehdi, Prodromou, Chrisostomos, Pearl, Laurence H, Piper, Peter W

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Mnsod overexpression extends the yeast chronological (G 0) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells by Harris, Nicholas, Costa, Vitor, MacLean, Morag, Mollapour, Mehdi, Moradas-Ferreira, Pedro, Piper, Peter W

“…Studies in Drosophila and Caenorhabditis elegans have shown increased longevity with the increased free radical scavenging that accompanies overexpression of…”
Get full text

In the Yeast Heat Shock Response, Hsf1-Directed Induction of Hsp90 Facilitates the Activation of the Slt2 (Mpk1) Mitogen-Activated Protein Kinase Required for Cell Integrity by Truman, Andrew W, Millson, Stefan H, Nuttall, James M, Mollapour, Mehdi, Prodromou, Chrisostomos, Piper, Peter W

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Saccharomyces cerevisiae weak-acid-inducible ABC transporter Pdr12 transports fluorescein and preservative anions from the cytosol by an energy-dependent mechanism by Holyoak, C.D, Bracey, D, Piper, P.W, Kuchler, K, Coote, P.J

“…Growth of Saccharomyces cerevisiae in the presence of the weak-acid preservative sorbic acid results in the induction of the ATP-binding cassette (ABC)…”
Get full text