Search Results - "Piper, Karen"

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis by Martin, Katherine, Pritchett, James, Llewellyn, Jessica, Mullan, Aoibheann F., Athwal, Varinder S., Dobie, Ross, Harvey, Emma, Zeef, Leo, Farrow, Stuart, Streuli, Charles, Henderson, Neil C., Friedman, Scott L., Hanley, Neil A., Piper Hanley, Karen

“…Fibrosis due to extracellular matrix (ECM) secretion from myofibroblasts complicates many chronic liver diseases causing scarring and organ failure…”
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Development of the Human Pancreas From Foregut to Endocrine Commitment by JENNINGS, Rachel E, BERRY, Andrew A, KIRKWOOD-WILSON, Rebecca, ROBERTS, Neil A, HEARN, Thomas, SALISBURY, Rachel J, BLAYLOCK, Jennifer, HANLEY, Karen Piper, HANLEY, Neil A

“…Knowledge of human pancreas development underpins our interpretation and exploitation of human pluripotent stem cell (PSC) differentiation toward a β-cell…”
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Genetic Contribution to Non-alcoholic Fatty Liver Disease and Prognostic Implications by Martin, Katherine, Hatab, Anas, Athwal, Varinder S., Jokl, Elliot, Piper Hanley, Karen

“…Purpose of Review Non-alcoholic fatty liver disease (NAFLD) is a major and increasing health burden, with the potential to overwhelm hepatology services…”
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An integrative transcriptomic atlas of organogenesis in human embryos by Gerrard, Dave T, Berry, Andrew A, Jennings, Rachel E, Piper Hanley, Karen, Bobola, Nicoletta, Hanley, Neil A

“…Human organogenesis is when severe developmental abnormalities commonly originate. However, understanding this critical embryonic phase has relied upon…”
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SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis by Athwal, Varinder S., Pritchett, James, Martin, Katherine, Llewellyn, Jessica, Scott, Jennifer, Harvey, Emma, Zaitoun, Abed M., Mullan, Aoibheann F., Zeef, Leo A. H., Friedman, Scott L., Irving, William L., Hanley, Neil A., Guha, Indra N., Piper Hanley, Karen

“…Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators…”
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The Price of Thirst: Global Water Inequality and the Coming Chaos by Piper, Karen

“…"There's Money in Thirst," reads a headline in the New York Times. The CEO of Nestlé, purveyor of bottled water, heartily agrees. It is important to give water…”
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Understanding the role of SOX9 in acquired diseases: lessons from development by Pritchett, James, Athwal, Varinder, Roberts, Neil, Hanley, Neil A, Hanley, Karen Piper

“…The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder…”
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The prevalence and burden of Rome IV bowel disorders of gut brain interaction in patients with non-alcoholic fatty liver disease: a cross-sectional study by Purssell, Huw, Bennett, Lucy, Street, Oliver, Hanley, Karen Piper, Hanley, Neil, Vasant, Dipesh H., Athwal, Varinder S.

“…Rome IV bowel disorders of gut brain interaction (DGBI) and non-alcoholic fatty liver disease (NAFLD) are highly prevalent entities with overlapping…”
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PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis by Jokl, Elliot, Mullan, Aoibheann F., Simpson, Kara, Birchall, Lindsay, Pearmain, Laurence, Martin, Katherine, Pritchett, James, Raza, Sayyid, Shah, Rajesh, Hodson, Nigel W., Williams, Craig J., Camacho, Elizabeth, Zeef, Leo, Donaldson, Ian, Athwal, Varinder S., Hanley, Neil A., Piper Hanley, Karen

“…Myofibroblasts are responsible for scarring during fibrosis. The scar propagates mechanical signals inducing a radical transformation in myofibroblast cell…”
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Human notochordal cell transcriptome unveils potential regulators of cell function in the developing intervertebral disc by Rodrigues-Pinto, Ricardo, Ward, Lizzy, Humphreys, Matthew, Zeef, Leo A. H., Berry, Andrew, Hanley, Karen Piper, Hanley, Neil, Richardson, Stephen M., Hoyland, Judith A.

“…The adult nucleus pulposus originates from the embryonic notochord, but loss of notochordal cells with skeletal maturity in humans is thought to contribute to…”
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Unlocking the post-transplant microenvironment for successful islet function and survival by Doherty, Daniel T., Khambalia, Hussein A., van Dellen, David, Jennings, Rachel E., Piper Hanley, Karen

“…Islet transplantation (IT) offers the potential to restore euglycemia for patients with type 1 diabetes mellitus (T1DM). Despite improvements in islet…”
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DNA and modified vaccinia Ankara prime–boost vaccination generates strong CD8+ T cell responses against minor histocompatibility antigen HA‐1 by Eldershaw, Suzy A., Pearce, Hayden, Inman, Charlotte F., Piper, Karen P., Abbotts, Ben, Stephens, Christine, Nicol, Samantha, Croft, Wayne, Powell, Richard, Begum, Jusnara, Taylor, Graham, Nunnick, Jane, Walsh, Donna, Sirovica, Mirjana, Saddique, Shamyla, Nagra, Sandeep, Ferguson, Paul, Moss, Paul, Malladi, Ram

“…Summary Allogeneic immune responses underlie the graft‐versus‐leukaemia effect of stem cell transplantation, but disease relapse occurs in many patients. Minor…”
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SOX9 predicts progression toward cirrhosis in patients while its loss protects against liver fibrosis by Athwal, Varinder S, Pritchett, James, Llewellyn, Jessica, Martin, Katherine, Camacho, Elizabeth, Raza, Sayyid MA, Phythian‐Adams, Alexander, Birchall, Lindsay J, Mullan, Aoibheann F, Su, Kim, Pearmain, Laurence, Dolman, Grace, Zaitoun, Abed M, Friedman, Scott L, MacDonald, Andrew, Irving, William L, Guha, Indra N, Hanley, Neil A, Piper Hanley, Karen

“…Fibrosis and organ failure is a common endpoint for many chronic liver diseases. Much is known about the upstream inflammatory mechanisms provoking fibrosis…”
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In humans, early cortisol biosynthesis provides a mechanism to safeguard female sexual development by Goto, Masahiro, Piper Hanley, Karen, Marcos, Josep, Wood, Peter J, Wright, Sarah, Postle, Anthony D, Cameron, Iain T, Mason, J Ian, Wilson, David I, Hanley, Neil A

“…In humans, sexual differentiation of the external genitalia is established at 7-12 weeks post conception (wpc). During this period, maintaining the appropriate…”
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Review article: epidemiology, pathogenesis and management of liver disease in adults with cystic fibrosis by Scott, Jennifer, Jones, Andrew M., Piper Hanley, Karen, Athwal, Varinder S.

“…Summary Background Cystic fibrosis‐related liver disease (CFLD) is the leading cause of death in cystic fibrosis (CF), after pulmonary disease. To improve…”
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Laser Capture and Deep Sequencing Reveals the Transcriptomic Programmes Regulating the Onset of Pancreas and Liver Differentiation in Human Embryos by Jennings, Rachel E., Berry, Andrew A., Gerrard, David T., Wearne, Stephen J., Strutt, James, Withey, Sarah, Chhatriwala, Mariya, Piper Hanley, Karen, Vallier, Ludovic, Bobola, Nicoletta, Hanley, Neil A.

“…To interrogate the alternative fates of pancreas and liver in the earliest stages of human organogenesis, we developed laser capture, RNA amplification, and…”
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Improving detection of cystic fibrosis related liver disease using liver fibrosis assessment tools by Scott, Jennifer A., Jones, Andrew M., Jokl, Elliot, Gordon-Walker, Timothy, Barry, Peter J., Hanley, Neil A., Piper Hanley, Karen, Athwal, Varinder S.

“…Cystic Fibrosis related liver disease (CFLD) is the 3rd largest cause of death in Cystic Fibrosis (CF). As advances in pulmonary therapies have increased…”
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Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders by Gerrard, Dave T., Berry, Andrew A., Jennings, Rachel E., Birket, Matthew J., Zarrineh, Peyman, Garstang, Myles G., Withey, Sarah L., Short, Patrick, Jiménez-Gancedo, Sandra, Firbas, Panos N., Donaldson, Ian, Sharrocks, Andrew D., Hanley, Karen Piper, Hurles, Matthew E., Gomez-Skarmeta, José Luis, Bobola, Nicoletta, Hanley, Neil A.

“…How the genome activates or silences transcriptional programmes governs organ formation. Little is known in human embryos undermining our ability to benchmark…”
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CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation by Piper, Karen P., Horlock, Claire, Curnow, S. John, Arrazi, Julie, Nicholls, Sarah, Mahendra, Premini, Craddock, Charles, Moss, Paul A.H.

“…Acute graft-versus-host disease (aGVHD) remains a serious complication following allogeneic stem-cell transplantation (SCT), and is mediated by infiltration of…”
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Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis by Piper Hanley, Karen, Oakley, Fiona, Sugden, Sarah, Wilson, David I., Mann, Derek A., Hanley, Neil A.

“…Appropriate temporospatial expression of the transcription factor SOX9 is important for normal development of a wide range of organs. Here, we show that when…”
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