Good clinical practices and inpatient antibiotics: optimization of fluoroquinolone switch therapy
Intravenous-to-oral switch therapy is strongly recommended in the medical literature. The aim of this study was to assess how we can improve fluoroquinolone switch therapy. this comparative prospective study, we analyzed 243 intravenous ciprofloxacin treatments and assessed the impact of promoting a...
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| Published in: | La Presse médicale (1983) Vol. 36; no. 9; pp. 1159 - 1166 |
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| Main Authors: | , , , , , , , |
| Format: | Journal Article |
| Language: | French |
| Published: |
01-09-2007
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| Online Access: | Get full text |
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| Summary: | Intravenous-to-oral switch therapy is strongly recommended in the medical literature. The aim of this study was to assess how we can improve fluoroquinolone switch therapy. this comparative prospective study, we analyzed 243 intravenous ciprofloxacin treatments and assessed the impact of promoting a switch to oral step-down therapy. This study found that switches from intravenous to oral therapy increased, mainly in medical wards, and led to significant savings in direct costs. Promoting switch therapy has improved clinical practices in antibiotic use and led to lower direct and probably indirect drug-related costs. Our findings will help define the role of switch therapy in improving clinical practices in inpatient antibiotic use.Original Abstract: La consommation excessive des antibiotiques dans les hopitaux est a l'origine de nombreuses recommandations pour la rationalisation de leur usage, notamment par l'encouragement des relais par voie orale. L'objectif de ce travail etait d'etablir les reelles capacites d'optimisation de ces relais au CHU de Dijon, en prenant l'exemple de la ciprofloxacine. L'etude prospective et comparative a analyse 243 traitements antibiotiques inities par voie injectable et evalue l'impact de la promotion des relais per os sur ces prescriptions. L'intervention pharmaceutique en faveur du relais per os a montre une augmentation significative (p < 0,01) de la frequence des relais per os dans les services de medecine, qui s'accompagne d'une diminution des couts directs evaluee a 4 000 euros sur 2 mois. Cette etude a permis de mettre en evidence une amelioration en faveur du bon usage des antibiotiques. Aux economies realisees peuvent s'ajouter une diminution des couts d'administration et des durees d'hospitalisation. Ces resultats permettront de definir la place de la promotion des relais per os dans la politique interne de l'etablissement pour le bon usage des antibiotiques. |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 23 ObjectType-Feature-1 |
| ISSN: | 0755-4982 |
| DOI: | 10.1016/j.lpm.2007.01.038 |