Search Results - "Piotrowski, Jeff S."

Inhibiting Stearoyl-CoA Desaturase Ameliorates α-Synuclein Cytotoxicity by Vincent, Benjamin M., Tardiff, Daniel F., Piotrowski, Jeff S., Aron, Rebecca, Lucas, Matthew C., Chung, Chee Yeun, Bacherman, Helene, Chen, YiQun, Pires, Michelle, Subramaniam, Radha, Doshi, Dimple B., Sadlish, Heather, Raja, Waseem K., Solís, Eric J., Khurana, Vikram, Le Bourdonnec, Bertrand, Scannevin, Robert H., Rhodes, Kenneth J.

“…The lack of disease-modifying treatments for neurodegenerative disease stems in part from our rudimentary understanding of disease mechanisms and the paucity…”
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Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin by Adnani, Navid, Chevrette, Marc G, Adibhatla, Srikar N, Zhang, Fan, Yu, Qing, Braun, Doug R, Nelson, Justin, Simpkins, Scott W, McDonald, Bradon R, Myers, Chad L, Piotrowski, Jeff S, Thompson, Christopher J, Currie, Cameron R, Li, Lingjun, Rajski, Scott R, Bugni, Tim S

“…Advances in genomics and metabolomics have made clear in recent years that microbial biosynthetic capacities on Earth far exceed previous expectations. This is…”
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Improving Measures of Chemical Structural Similarity Using Machine Learning on Chemical–Genetic Interactions by Safizadeh, Hamid, Simpkins, Scott W, Nelson, Justin, Li, Sheena C, Piotrowski, Jeff S, Yoshimura, Mami, Yashiroda, Yoko, Hirano, Hiroyuki, Osada, Hiroyuki, Yoshida, Minoru, Boone, Charles, Myers, Chad L

“…A common strategy for identifying molecules likely to possess a desired biological activity is to search large databases of compounds for high structural…”
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Functional annotation of chemical libraries across diverse biological processes by Piotrowski, Jeff S, Li, Sheena C, Deshpande, Raamesh, Simpkins, Scott W, Nelson, Justin, Yashiroda, Yoko, Barber, Jacqueline M, Safizadeh, Hamid, Wilson, Erin, Okada, Hiroki, Gebre, Abraham A, Kubo, Karen, Torres, Nikko P, LeBlanc, Marissa A, Andrusiak, Kerry, Okamoto, Reika, Yoshimura, Mami, DeRango-Adem, Eva, van Leeuwen, Jolanda, Shirahige, Katsuhiko, Baryshnikova, Anastasia, Brown, Grant W, Hirano, Hiroyuki, Costanzo, Michael, Andrews, Brenda, Ohya, Yoshikazu, Osada, Hiroyuki, Yoshida, Minoru, Myers, Chad L, Boone, Charles

“…Profiling of over 13,000 compounds against yeast gene deletion mutants, defining the differential responses on cells, reveals chemical-genetic interactions…”
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Plant-derived antifungal agent poacic acid targets β-1,3-glucan by Piotrowski, Jeff S., Okada, Hiroki, Lu, Fachuang, Li, Sheena C., Hinchman, Li, Ranjan, Ashish, Smith, Damon L., Higbee, Alan J., Ulbrich, Arne, Coon, Joshua J., Deshpande, Raamesh, Bukhman, Yury V., McIlwain, Sean, Ong, Irene M., Myers, Chad L., Boone, Charles, Landick, Robert, Ralph, John, Kabbage, Mehdi, Ohya, Yoshikazu

“…A rise in resistance to current antifungals necessitates strategies to identify alternative sources of effective fungicides. We report the discovery of poacic…”
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Accumulation of heme biosynthetic intermediates contributes to the antibacterial action of the metalloid tellurite by Morales, Eduardo H., Pinto, Camilo A., Luraschi, Roberto, Muñoz-Villagrán, Claudia M., Cornejo, Fabián A., Simpkins, Scott W., Nelson, Justin, Arenas, Felipe A., Piotrowski, Jeff S., Myers, Chad L., Mori, Hirotada, Vásquez, Claudio C.

“…The metalloid tellurite is highly toxic to microorganisms. Several mechanisms of action have been proposed, including thiol depletion and generation of…”
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Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments by Simpkins, Scott W., Deshpande, Raamesh, Nelson, Justin, Li, Sheena C., Piotrowski, Jeff S., Ward, Henry Neil, Yashiroda, Yoko, Osada, Hiroyuki, Yoshida, Minoru, Boone, Charles, Myers, Chad L.

“…The construction of genome-wide mutant collections has enabled high-throughput, high-dimensional quantitative characterization of gene and chemical function,…”
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MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action by Nelson, Justin, Simpkins, Scott W, Safizadeh, Hamid, Li, Sheena C, Piotrowski, Jeff S, Hirano, Hiroyuki, Yashiroda, Yoko, Osada, Hiroyuki, Yoshida, Minoru, Boone, Charles, Myers, Chad L

“…Abstract Summary Chemical-genomic approaches that map interactions between small molecules and genetic perturbations offer a promising strategy for functional…”
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Death by a thousand cuts: the challenges and diverse landscape of lignocellulosic hydrolysate inhibitors by Piotrowski, Jeff S, Zhang, Yaoping, Bates, Donna M, Keating, David H, Sato, Trey K, Ong, Irene M, Landick, Robert

“…Lignocellulosic hydrolysate (LCH) inhibitors are a large class of bioactive molecules that arise from pretreatment, hydrolysis, and fermentation of plant…”
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Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions by Simpkins, Scott W, Nelson, Justin, Deshpande, Raamesh, Li, Sheena C, Piotrowski, Jeff S, Wilson, Erin H, Gebre, Abraham A, Safizadeh, Hamid, Okamoto, Reika, Yoshimura, Mami, Costanzo, Michael, Yashiroda, Yoko, Ohya, Yoshikazu, Osada, Hiroyuki, Yoshida, Minoru, Boone, Charles, Myers, Chad L

“…Chemical-genetic interactions-observed when the treatment of mutant cells with chemical compounds reveals unexpected phenotypes-contain rich functional…”
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Chemical-genomic profiling: Systematic analysis of the cellular targets of bioactive molecules by Andrusiak, Kerry, Piotrowski, Jeff S., Boone, Charles

“…Chemical-genomic (CG) profiling of bioactive compounds is a powerful approach for drug target identification and mode of action studies. Within the last…”
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Soft-metal(loid)s induce protein aggregation in Escherichia coli by Cornejo, Fabián A, Muñoz-Villagrán, Claudia, Luraschi, Roberto A, Sandoval-Díaz, María P, Cancino, Camila A, Pugin, Benoit, Morales, Eduardo H, Piotrowski, Jeff S, Sandoval, Juan M, Vásquez, Claudio C, Arenas, Felipe A

“…Metal(loid) salts were used to treat infectious diseases in the past due to their exceptional biocidal properties at low concentrations. However, the mechanism…”
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Different selective pressures lead to different genomic outcomes as newly-formed hybrid yeasts evolve by Piotrowski, Jeff S, Nagarajan, Saisubramanian, Kroll, Evgueny, Stanbery, Alison, Chiotti, Kami E, Kruckeberg, Arthur L, Dunn, Barbara, Sherlock, Gavin, Rosenzweig, Frank

“…Interspecific hybridization occurs in every eukaryotic kingdom. While hybrid progeny are frequently at a selective disadvantage, in some instances their…”
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Chemical genomic guided engineering of gamma-valerolactone tolerant yeast by Bottoms, Scott, Dickinson, Quinn, McGee, Mick, Hinchman, Li, Higbee, Alan, Hebert, Alex, Serate, Jose, Xie, Dan, Zhang, Yaoping, Coon, Joshua J, Myers, Chad L, Landick, Robert, Piotrowski, Jeff S

“…Gamma valerolactone (GVL) treatment of lignocellulosic bomass is a promising technology for degradation of biomass for biofuel production; however, GVL is…”
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Genome-wide screening of genes associated with momilactone B sensitivity in the fission yeast Schizosaccharomyces pombe by Tomita, Keisuke, Yashiroda, Yoko, Matsuo, Yasuhiro, Piotrowski, Jeff S, Li, Sheena C, Okamoto, Reika, Yoshimura, Mami, Kimura, Hiromi, Kawamura, Yumi, Kawamukai, Makoto, Boone, Charles, Yoshida, Minoru, Nojiri, Hideaki, Okada, Kazunori

“…Momilactone B is a natural product with dual biological activities, including antimicrobial and allelopathic properties, and plays a major role in plant…”
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Chemical Genomics, Structure Elucidation, and in Vivo Studies of the Marine-Derived Anticlostridial Ecteinamycin by Wyche, Thomas P, Alvarenga, René F. Ramos, Piotrowski, Jeff S, Duster, Megan N, Warrack, Simone R, Cornilescu, Gabriel, De Wolfe, Travis J, Hou, Yanpeng, Braun, Doug R, Ellis, Gregory A, Simpkins, Scott W, Nelson, Justin, Myers, Chad L, Steele, James, Mori, Hirotada, Safdar, Nasia, Markley, John L, Rajski, Scott R, Bugni, Tim S

“…A polyether antibiotic, ecteinamycin (1), was isolated from a marine Actinomadura sp., cultivated from the ascidian Ecteinascidia turbinata. 13C enrichment,…”
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Chemical genomic profiling via barcode sequencing to predict compound mode of action by Piotrowski, Jeff S, Simpkins, Scott W, Li, Sheena C, Deshpande, Raamesh, McIlwain, Sean J, Ong, Irene M, Myers, Chad L, Boone, Charlie, Andersen, Raymond J

“…Chemical genomics is an unbiased, whole-cell approach to characterizing novel compounds to determine mode of action and cellular target. Our version of this…”
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Padanamides A and B, Highly Modified Linear Tetrapeptides Produced in Culture by a Streptomyces sp. Isolated from a Marine Sediment by Williams, David. E, Dalisay, Doralyn S, Patrick, Brian O, Matainaho, Teatulohi, Andrusiak, Kerry, Deshpande, Raamesh, Myers, Chad L, Piotrowski, Jeff S, Boone, Charles, Yoshida, Minoru, Andersen, Raymond J

“…Two highly modified linear tetrapeptides, padanamides A (1) and B (2), are produced by laboratory cultures of a Streptomyces sp. obtained from a marine…”
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Mutations That Alter the Bacterial Cell Envelope Increase Lipid Production by Lemmer, Kimberly C, Zhang, Weiping, Langer, Samantha J, Dohnalkova, Alice C, Hu, Dehong, Lemke, Rachelle A, Piotrowski, Jeff S, Orr, Galya, Noguera, Daniel R, Donohue, Timothy J

“…Lipids from microbes offer a promising source of renewable alternatives to petroleum-derived compounds. In particular, oleaginous microbes are of interest…”
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High-throughput platform for yeast morphological profiling predicts the targets of bioactive compounds by Ohnuki, Shinsuke, Ogawa, Itsuki, Itto-Nakama, Kaori, Lu, Fachuang, Ranjan, Ashish, Kabbage, Mehdi, Gebre, Abraham Abera, Yamashita, Masao, Li, Sheena C., Yashiroda, Yoko, Yoshida, Satoshi, Usui, Takeo, Piotrowski, Jeff S., Andrews, Brenda J., Boone, Charles, Brown, Grant W., Ralph, John, Ohya, Yoshikazu

“…Morphological profiling is an omics-based approach for predicting intracellular targets of chemical compounds in which the dose-dependent morphological changes…”
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