Search Results - "Pioro, E. P."

A randomized controlled trial of resistance exercise in individuals with ALS by DAL BELLO-HAAS, V, FLORENCE, J. M, KLOOS, A. D, SCHEIRBECKER, J, LOPATE, G, HAYES, S. M, PIORO, E. P, MITSUMOTO, H

“…To determine the effects of resistance exercise on function, fatigue, and quality of life in individuals with ALS. Subjects with a diagnosis of clinically…”
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2‐Deoxy‐2‐[18F]fluoro‐d‐glucose positron emission tomography, cortical thickness and white matter graph network abnormalities in brains of patients with amyotrophic lateral sclerosis and frontotemporal dementia suggest early neuronopathy rather than axonopathy by Rajagopalan, V., Pioro, E. P.

“…Background and purpose Amyotrophic lateral sclerosis (ALS) is a motor neuron disorder, although extra‐motor degeneration is well recognized, especially in…”
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Assessment of bulbar function in amyotrophic lateral sclerosis: validation of a self‐report scale (Center for Neurologic Study Bulbar Function Scale) by Smith, R. A., Macklin, E. A., Myers, K. J., Pattee, G. L., Goslin, K. L., Meekins, G. D., Green, J. R., Shefner, J. M., Pioro, E. P.

“…Background and purpose Impaired bulbar functions of speech and swallowing are among the most serious consequences of amyotrophic lateral sclerosis (ALS)…”
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Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system--I. Forebrain by Pioro, E P, Cuello, A C

“…Nerve growth factor receptor, as recognized by the monoclonal antibody 192-IgG, was localized to multiple regions of the adult rat forebrain. Immunoreactive…”
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Distribution of nerve growth factor receptor-like immunoreactivity in the adult rat central nervous system. Effect of colchicine and correlation with the cholinergic system--II. Brainstem, cerebellum and spinal cord by Pioro, E P, Cuello, A C

“…Multiple nuclei and fiber tracts in the adult rat brainstem and spinal cord were found to contain nerve growth factor receptor-related protein, as recognized…”
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MR spectroscopy in amyotrophic lateral sclerosis/motor neuron disease by Pioro, Erik P

“…Proton magnetic resonance spectroscopy ( 1H-MRS) and proton magnetic resonance spectroscopic imaging ( 1H-MRSI) have been used to identify neuronal dysfunction…”
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Neuronal pathology in the wobbler mouse brain revealed by in vivo proton magnetic resonance spectroscopy and immunocytochemistry by Pioro, Erik P, Wang, Yang, Moore, Joanna K, Ng, Thian C, Trapp, Bruce D, Klinkosz, Bogdan, Mitsumoto, Hiroshi

“…PROTON magnetic resonance spectroscopy (H-MRS) was used to measure the in vivo signal of N-acetylaspartate (NAA), a putative neuronal marker, in the brain of…”
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Substance P- and enkephalin-like immunoreactivities are colocalized in certain neurons of the substantia gelatinosa of the rat spinal cord: an ultrastructural double-labeling study by Ribeiro-da-Silva, A, Pioro, EP, Cuello, AC

“…The finding that certain cells of the substantia gelatinosa of the rat spinal cord contain both substance P (SP)- and enkephalin (ENK)-like immunoreactive…”
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Long-term protective effects of human recombinant nerve growth factor and monosialoganglioside GM1 treatment on primate nucleus basalis cholinergic neurons after neocortical infarction by Liberini, P, Pioro, E P, Maysinger, D, Ervin, F R, Cuello, A C

“…Neocortical infarction induces biochemical and morphological retrograde degenerative changes in cholinergic neurons of the rat nucleus basalis magnocellularis…”
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A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis by Cudkowicz, M E, Shefner, J M, Schoenfeld, D A, Brown, Jr, R H, Johnson, H, Qureshi, M, Jacobs, M, Rothstein, J D, Appel, S H, Pascuzzi, R M, Heiman-Patterson, T D, Donofrio, P D, David, W S, Russell, J A, Tandan, R, Pioro, E P, Felice, K J, Rosenfeld, J, Mandler, R N, Sachs, G M, Bradley, W G, Raynor, E M, Baquis, G D, Belsh, J M, Novella, S, Goldstein, J, Hulihan, J

“…To determine if long-term topiramate therapy is safe and slows disease progression in patients with ALS. A double-blind, placebo-controlled, multicenter…”
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Genetic transfer of the wobbler gene to a C57BL/6J x NZB hybrid stock: Natural history of the motor neuron disease and response to CNTF and BDNF cotreatment by ISHIYAMA, T, KLINKOSZ, B, PIORO, E. P, MITSUMOTO, H

“…Preclinical diagnosis of motor neuron disease (MND) in the wobbler mouse (wr/wr) has been impossible until recently. However, with the development of a new…”
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Purkinje cells of adult rat cerebellum express nerve growth factor receptor immunoreactivity: light microscopic observations by Pioro, E P, Cuello, A C

“…Adult rat cerebellum was examined for the presence of nerve growth factor receptor (NGFr) immunoreactivity (IR) using the monoclonal antibody 192-IgG. In…”
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Neocortical infarction in subhuman primates leads to restricted morphological damage of the cholinergic neurons in the nucleus basalis of Meynert by Liberini, P, Pioro, E P, Maysinger, D, Cuello, A C

“…The aim of the present study was to investigate the long-term effect of cortical infarction on the subhuman primate (Cercopithecus aethiops) basal forebrain…”
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Detection of cortical neuron loss in motor neuron disease by proton magnetic resonance spectroscopic imaging in vivo by Pioro, E P, Antel, J P, Cashman, N R, Arnold, D L

“…We performed proton magnetic resonance spectroscopic imaging (1H-MRSI) in patients with motor neuron disease (MND) to evaluate the distribution and extent of…”
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Dysmyelinated Lower Motor Neurons Retract and Regenerate Dysfunctional Synaptic Terminals by Yin, Xinghua, Kidd, Grahame J, Pioro, Erik P, McDonough, Jennifer, Dutta, Ranjan, Feltri, M. Laura, Wrabetz, Lawrence, Messing, Albee, Wyatt, Ryan M, Balice-Gordon, Rita J, Trapp, Bruce D

“…Axonal degeneration is the major cause of permanent neurological disability in individuals with inherited diseases of myelin. Axonal and neuronal changes that…”
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Similarities in the ultrastructural distribution of nerve growth factor receptor-like immunoreactivity in cerebellar Purkinje cells of the neonatal and colchicine-treated adult rat by Pioro, E P, Ribeiro-Da-Silva, A, Cuello, A C

“…The intracellular distribution of nerve growth factor receptor immunoreactivity was examined by electron microscopy in the cerebellum of adult and postnatal…”
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Primate nucleus basalis of Meynert p75NGFR-containing cholinergic neurons are protected from retrograde degeneration by the ganglioside GM1 by Pioro, E P, Maysinger, D, Ervin, F R, Desypris, G, Cuello, A C

“…The effects of unilateral devascularizing lesions of the neocortex in primates (Cercopithecus aethiops) on the immunoreactivity of choline acetyltransferase…”
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Animal models of amyotrophic lateral sclerosis by Mitsumoto, H, Pioro, E P

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Loss of substance P and enkephalin immunoreactivity in the human substantia nigra after striato-pallidal infarction by Pioro, E P, Hughes, J T, Cuello, A C

“…Post-mortem neuropathological material from 3 patients with striato-pallidal infarction provided the first immunohistochemical evidence for substance P- and…”
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Role of brain-derived neurotrophic factor in wobbler mouse motor neuron disease by Tsuzaka, Kazufumi, Ishiyama, Takeo, Pioro, Erik P., Mitsumoto, Hiroshi

“…Brain‐derived neurotrophic factor (BDNF) is neuroprotective for motoneurons undergoing degeneration, including those in natural motor neuron disease (MND) in…”
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