Abstract 179: Accessing the Swine Middle Meningeal Artery to Evaluate a Novel Embolic Agent IMPASS

IntroductionMiddle meningeal artery (MMA) embolization has emerged as a promising stand‐alone or adjunct treatment for patients with chronic subdural hematomas (cSDH). Improved penetration of the MMA is believed to improve the efficacy of the embolization procedure and its long‐term clinical success...

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Bibliographic Details
Published in:	Stroke: vascular and interventional neurology Vol. 4; no. S1
Main Authors:	Mokin, M, Pionessa, D, Koenigsknecht, C, Gutierrez, L, S Setlur Nagesh, Bainsmith, M, Smith, D, Siddiqui, A H
Format:	Journal Article
Language:	English
Published:	Phoenix Wiley Subscription Services, Inc 01-11-2024
Subjects:	Embolization Veins & arteries
Online Access:	Get full text
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Summary:	IntroductionMiddle meningeal artery (MMA) embolization has emerged as a promising stand‐alone or adjunct treatment for patients with chronic subdural hematomas (cSDH). Improved penetration of the MMA is believed to improve the efficacy of the embolization procedure and its long‐term clinical success. The goal of this feasibility study is to evaluate the performance of a novel liquid embolic (IMPASS, Fluidx Medical Technology) compared with a control (Onyx 18, Medtronic) in a swine MMA embolization model.Materials and MethodsIMPASS is a water‐based liquid embolic material which follows vascular flow and is designed for deep distal penetration. It is DMSO free and requires minimal preparation. Using the in vivo model of selective MMA embolization in swine, the MMA branch of the external carotid artery was targeted for microcatheter access in one hemisphere. Both control (Onyx 18; n=3) and test embolic material (IMPASS; n=3) were delivered through a microcatheter. Digital subtraction angiography was used to determine success of embolization immediately following each procedure. After 14 ± 1 days, arteriography was used to confirm occlusion of the targeted MMA branches.ResultsThe MMA was successfully accessed and embolized with both test and control embolic materials in all six animals (Fig 1). Arteriography confirmed full occlusion of the MMA by both test and control embolics, with no recanalization observed. The swine were survived 14 ± 1 days with no significant clinical observations. The control article was found to reach vessels with a diameter of 100 microns and the test article was found to reach arterioles with a diameter of 20 microns.ConclusionsEarly feasibility data using IMPASS demonstrated deep distal penetration indicating that it may be well suited for MMA embolization in patients with cSDH and other non‐shunting neurovascular applications. Future studies are planned.
ISSN:	2694-5746 2694-5746
DOI:	10.1161/SVIN.04.suppl_1.179