Search Results - "Pintucci, Giuseppe"

Transforming growth factor-beta 1 (TGF-β1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis by Ferrari, Giovanni, Cook, Brandoch D., Terushkin, Vitaly, Pintucci, Giuseppe, Mignatti, Paolo

“…VEGF and TGF‐β1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF‐β1 induces apoptosis…”
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VEGF, a Prosurvival Factor, Acts in Concert with TGF-β1 to Induce Endothelial Cell Apoptosis by Ferrari, Giovanni, Pintucci, Giuseppe, Seghezzi, Graziano, Hyman, Kevin, Galloway, Aubrey C., Mignatti, Paolo

“…VEGF and TGF-β1 are potent angiogenesis inducers with opposing effects on endothelial cells. TGF-β1 induces apoptosis; VEGF protects endothelial cells from…”
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Protein targets of inflammatory serine proteases and cardiovascular disease by Sharony, Ram, Yu, Pey-Jen, Park, Joy, Galloway, Aubrey C, Mignatti, Paolo, Pintucci, Giuseppe

“…Serine proteases are a key component of the inflammatory response as they are discharged from activated leukocytes and mast cells or generated through the…”
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Basic fibroblast growth factor (FGF-2): The high molecular weight forms come of age by Yu, Pey-Jen, Ferrari, Giovanni, Galloway, Aubrey C., Mignatti, Paolo, Pintucci, Giuseppe

“…After over thirty years from its discovery, research on basic fibroblast growth factor (FGF‐2) keeps revealing new aspects of the complexity of its gene…”
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Tissue Inhibitor of Metalloproteinases-2 Binding to Membrane-type 1 Matrix Metalloproteinase Induces MAPK Activation and Cell Growth by a Non-proteolytic Mechanism by D'Alessio, Silvia, Ferrari, Giovanni, Cinnante, Karma, Scheerer, William, Galloway, Aubrey C., Roses, Daniel F., Rozanov, Dmitri V., Remacle, Albert G., Oh, Eok-Soo, Shiryaev, Sergey A., Strongin, Alex Y., Pintucci, Giuseppe, Mignatti, Paolo

“…Membrane-type 1 matrix metalloproteinase (MT1-MMP), a transmembrane proteinase with a short cytoplasmic domain and an extracellular catalytic domain, controls…”
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Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis by Seghezzi, Graziano, Patel, Sundeep, Ren, Christine J., Gualandris, Anna, Pintucci, Giuseppe, Robbins, Edith S., Shapiro, Richard L., Galloway, Aubrey C., Rifkin, Daniel B., Mignatti, Paolo

“…FGF-2 and VEGF are potent angiogenesis inducers in vivo and in vitro. Here we show that FGF-2 induces VEGF expression in vascular endothelial cells through…”
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Correlation between plasma osteopontin levels and aortic valve calcification: Potential insights into the pathogenesis of aortic valve calcification and stenosis by Yu, Pey-Jen, MD, Skolnick, Adam, MD, Ferrari, Giovanni, PhD, Heretis, Katherine, MD, Mignatti, Paolo, MD, Pintucci, Giuseppe, PhD, Rosenzweig, Barry, MD, Diaz-Cartelle, Juan, MD, Kronzon, Itzhak, MD, Perk, Gila, MD, Pass, Harvey I., MD, Galloway, Aubrey C., MD, Grossi, Eugene A., MD, Grau, Juan B., MD

“…Objective The inflammatory process of aortic stenosis involves the differentiation of aortic valve myofibroblasts into osteoblasts. Osteopontin, a…”
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Trophic effects of platelets on cultured endothelial cells are mediated by platelet-associated fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor (VEGF) by Pintucci, Giuseppe, Froum, Scott, Pinnell, Jared, Mignatti, Paolo, Rafii, Shahin, Green, David

“…In addition to their role in primary hemostasis, platelets serve to support and maintain the vascular endothelium. Platelets contain numerous growth factors…”
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Matrix metalloproteinase expression in vein grafts: role of inflammatory mediators and extracellular signal-regulated kinases-1 and -2 by Sharony, Ram, Pintucci, Giuseppe, Saunders, Paul C, Grossi, Eugene A, Baumann, F Gregory, Galloway, Aubrey C, Mignatti, Paolo

“…Matrix metalloproteinases (MMPs) play key roles in vascular remodeling. We characterized the role of inflammatory mediators and extracellular signal-regulated…”
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Lack of ERK activation and cell migration in FGF‐2‐deficient endothelial cells by Pintucci, Giuseppe, Moscatelli, David, Saponara, Fiorella, Biernacki, Peter R., Baumann, F. Gregory, Bizekis, Costas, Galloway, Aubrey C., Basilico, Claudio, Mignatti, Paolo

“…ABSTRACT The formation of blood capillaries from preexisting vessels (angiogenesis) and vascular remodeling secondary to atherosclerosis or vessel injury are…”
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Topical Mitogen-Activated Protein Kinases Inhibition Reduces Intimal Hyperplasia in Arterialized Vein Grafts by Gulkarov, Iosif, M.D, Bohmann, Katja, M.D, Cinnante, Karma M., B.A, Pirelli, Luigi, M.D, Yu, Pey-Jen, M.D, Grau, Juan B., M.D, Pintucci, Giuseppe, Ph.D, Galloway, Aubrey C., M.D, Mignatti, Paolo, M.D

“…Objective Vein graft arterialization results in activation of the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinases-1 and -2…”
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Induction of stromelysin-1 (MMP-3) by fibroblast growth factor-2 (FGF-2) in FGF-2−/− microvascular endothelial cells requires prolonged activation of extracellular signal-regulated kinases-1 and -2 (ERK-1/2) by Pintucci, Giuseppe, Yu, Pey-Jen, Sharony, Ram, Baumann, F. Gregory, Saponara, Fiorella, Frasca, Antonio, Galloway, Aubrey C., Moscatelli, David, Mignatti, Paolo

“…Basic fibroblast growth factor (FGF‐2) and matrix metalloproteinases (MMPs) play key roles in vascular remodeling. Because FGF‐2 controls a number of…”
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Anti-proliferative and anti-inflammatory effects of topical MAPK inhibition in arterialized vein grafts by Pintucci, Giuseppe, Saunders, Paul C, Gulkarov, Iosif, Sharony, Ram, Kadian-Dodov, Daniella L, Bohmann, Katja, Baumann, F. Gregory, Galloway, Aubrey C, Mignatti, Paolo

“…ABSTRACT Vein graft failure following bypass surgery is a frequent and important clinical problem. The vascular injury caused by arterialization is responsible…”
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Biochemical Analysis of the Arginine Methylation of High Molecular Weight Fibroblast Growth Factor-2 by Klein, Sharon, Carroll, James A., Chen, Yan, Henry, Michael F., Henry, Pamela A., Ortonowski, Izabela E., Pintucci, Giuseppe, Beavis, Ronald C., Burgess, Wilson H., Rifkin, Daniel B.

“…The post-translational methylation of the N-terminally extended or high molecular weight (HMW) forms of fibroblast growth factor-2 (FGF-2) has been shown to…”
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Novel p27kip1 C-Terminal Scatter Domain Mediates Rac-Dependent Cell Migration Independent of Cell Cycle Arrest Functions by McAllister, Sandra S., Becker-Hapak, Michelle, Pintucci, Giuseppe, Pagano, Michele, Dowdy, Steven F.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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MAPK‐dependent expression of p21WAF and p27kip1 in PMA‐induced differentiation of HL60 cells by Das, Dipak, Pintucci, Giuseppe, Stern, Arnold

“…Treatment of HL60 cells with phorbol 12‐myristate 13‐acetate (PMA) results in growth arrest and differentiation towards the macrophage lineage. PMA‐induced…”
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TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α by Ferrari, Giovanni, Terushkin, Vitaly, Wolff, Martin J, Zhang, Xiaodong, Valacca, Cristina, Poggio, Paolo, Pintucci, Giuseppe, Mignatti, Paolo

“…TGF-β1 and VEGF, both angiogenesis inducers, have opposing effects on vascular endothelial cells. TGF-β1 induces apoptosis; VEGF induces survival. We have…”
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TGF-β1 induces rearrangement of FLK-1-VE-cadherin-β-catenin complex at the adherens junction through VEGF-mediated signaling by Cook, Brandoch D., Ferrari, Giovanni, Pintucci, Giuseppe, Mignatti, Paolo

“…VEGF and TGF‐β1 induce angiogenesis but have opposing effects on vascular endothelial cells: VEGF promotes survival; TGF‐β1 induces apoptosis. We have…”
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Biological Roles of Fibroblast Growth Factor-2 by Bikfalvi, A.

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Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions by McAllister, Sandra S, Becker-Hapak, Michelle, Pintucci, Giuseppe, Pagano, Michele, Dowdy, Steven F

“…Hepatocyte growth factor (HGF) signaling via its receptor, the proto-oncogene Met, alters cell proliferation and motility and has been associated with tumor…”
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