Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration

Expression of apoptosis regulatory proteins p53, bcl-2 and bax in recurrent aphthous ulceration

Background  Recurrent aphthous ulceration (RAU) is considered to be an acute inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation. Objectives  The aim of this study was to investigate apoptosis process in RAU using immunohistochemist...

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Bibliographic Details
Published in:Journal of the European Academy of Dermatology and Venereology Vol. 26; no. 10; pp. 1247 - 1251
Main Authors: Pinto Rodrigues, J.F.N., Fujiyama Oshima, C.T., Ribeiro Paiotti, A.P., Franco, M., Miki Ihara, S.S., Ribeiro, D.A.
Format: Journal Article
Language:English
Published: Oxford, UK Blackwell Publishing Ltd 01-10-2012
Subjects:
Adult
Apoptosis
Bax protein
Bcl-2 protein
bcl-2-Associated X Protein - metabolism
Data processing
Female
Humans
Hyperplasia
Immunohistochemistry
Inflammation
Inflammatory diseases
Male
Middle Aged
Mucosa
p53 protein
Proto-Oncogene Proteins c-bcl-2 - metabolism
Recurrence
regulatory proteins
Statistical analysis
Stomatitis, Aphthous - metabolism
Tumor Suppressor Protein p53 - metabolism
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Summary:Background  Recurrent aphthous ulceration (RAU) is considered to be an acute inflammatory disease of unknown pathogenesis. Apoptosis may represent an important event in the control of inflammation. Objectives  The aim of this study was to investigate apoptosis process in RAU using immunohistochemistry. Methods  We studied the expression and location of p53, bcl‐2 and bax in ulcerated lesions clinically diagnosed as RAU (n = 12) and compared it with that of oral clinically normal mucosa (n = 6) and of other inflammatory chronic disease such as oral fibrous inflammatory hyperplasia (FIH; n = 18). Results  Significant statistically differences (n < 0.05) in p53 expression were noticed in RAU when compared with normal mucosa. No significant statistically differences (P > 0.05) were noticed between FIH and RAU. Bcl‐2 and bax did not show remarkable differences between groups. Conclusions  Taken together, the data suggest that RAU induces p53 immunoexpression. Therefore, the protein might be related to the aetiopathogenesis of the ulcerated oral lesions.
Bibliography:istex:98CC13324C759648597906B2BE0D2D06DC80A407
ark:/67375/WNG-RS8C56XC-L
ArticleID:JDV4274
Conflict of interest 
None.
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SourceType-Scholarly Journals-1
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ISSN:0926-9959
1468-3083
DOI:10.1111/j.1468-3083.2011.04274.x