Search Results - "Pinto Couto, Joana"

The NFIB‐ERO1A axis promotes breast cancer metastatic colonization of disseminated tumour cells by Zilli, Federica, Marques Ramos, Pedro, Auf der Maur, Priska, Jehanno, Charly, Sethi, Atul, Coissieux, Marie‐May, Eichlisberger, Tobias, Sauteur, Loïc, Rouchon, Adelin, Bonapace, Laura, Pinto Couto, Joana, Rad, Roland, Jensen, Michael Rugaard, Banfi, Andrea, Stadler, Michael B, Bentires‐Alj, Mohamed

“…Metastasis is the main cause of deaths related to solid cancers. Active transcriptional programmes are known to regulate the metastatic cascade but the…”
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Glucocorticoids promote breast cancer metastasis by Obradović, Milan M. S., Hamelin, Baptiste, Manevski, Nenad, Couto, Joana Pinto, Sethi, Atul, Coissieux, Marie-May, Münst, Simone, Okamoto, Ryoko, Kohler, Hubertus, Schmidt, Alexander, Bentires-Alj, Mohamed

“…Diversity within or between tumours and metastases (known as intra-patient tumour heterogeneity) that develops during disease progression is a serious hurdle…”
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Nicotinamide N‐methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer by Couto, Joana Pinto, Vulin, Milica, Jehanno, Charly, Coissieux, Marie‐May, Hamelin, Baptiste, Schmidt, Alexander, Ivanek, Robert, Sethi, Atul, Bräutigam, Konstantin, Frei, Anja L, Hager, Carolina, Manivannan, Madhuri, Gómez‐Miragaya, Jorge, Obradović, Milan MS, Varga, Zsuzsanna, Koelzer, Viktor H, Mertz, Kirsten D, Bentires‐Alj, Mohamed

“…Metastatic colonization of distant organs accounts for over 90% of deaths related to solid cancers, yet the molecular determinants of metastasis remain poorly…”
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STAT3 negatively regulates thyroid tumorigenesis by Couto, Joana Pinto, Daly, Laura, Almeida, Ana, Knauf, Jeffrey A, Fagin, James A, Sobrinho-Simões, Manuel, Lima, Jorge, Máximo, Valdemar, Soares, Paula, Lyden, David, Bromberg, Jacqueline F

“…Although tyrosine-phosphorylated or activated STAT3 (pY-STAT3) is a well-described mediator of tumorigenesis, its role in thyroid cancer has not been…”
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Reply to: Hippo signalling maintains ER expression and ER+ breast cancer growth by Britschgi, Adrian, Couto, Joana Pinto, Bentires-Alj, Mohamed

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PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours by Koren, Shany, Reavie, Linsey, Couto, Joana Pinto, De Silva, Duvini, Stadler, Michael B, Roloff, Tim, Britschgi, Adrian, Eichlisberger, Tobias, Kohler, Hubertus, Aina, Olulanu, Cardiff, Robert D, Bentires-Alj, Mohamed

“…The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor…”
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PIK3CAH1047R induces multipotency and multi-lineage mammary tumours by Koren, Shany, Reavie, Linsey, Couto, Joana Pinto, De Silva, Duvini, Stadler, Michael B., Roloff, Tim, Britschgi, Adrian, Eichlisberger, Tobias, Kohler, Hubertus, Aina, Olulanu, Cardiff, Robert D., Bentires-Alj, Mohamed

“…PIK3CA mutations are associated with distinct types of human breast cancers but the cellular origin and mechanisms responsible for this heterogeneity were…”
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Couto, Joana Pinto, Brinkhaus, Heike, Koren, Shany, De Silva, Duvini, Mertz, Kirsten D., Kaup, Daniela, Varga, Zsuzsanna, Voshol, Hans, Vissieres, Alexandra, Leroy, Cedric, Roloff, Tim, Stadler, Michael B., Scheel, Christina H., Miraglia, Loren J., Orth, Anthony P., Bonamy, Ghislain M. C., Reddy, Venkateshwar A., Bentires-Alj, Mohamed

“…Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-α, thereby…”
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Hippo signalling maintains ER expression and ER breast cancer growth/Reply by Ma, Shenghong, Wu, Zhengming, Yang, Feng, Zhang, Jianmin, Johnson, Randy L, Rosenfeld, Michael G, Guan, Kun-Liang, Britschgi, Adrian, Couto, Joana Pinto, Bentires-Alj, Mohamed

“…By gene ontology enrichment analysis of the differentially expressed genes, we found an enrichment in the signatures for YAP target genes, as well as apoptosis…”
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A high-throughput drug screen reveals means to differentiate triple-negative breast cancer by Vulin, Milica, Jehanno, Charly, Sethi, Atul, Correia, Ana Luísa, Obradović, Milan M. S., Couto, Joana Pinto, Coissieux, Marie-May, Diepenbruck, Maren, Preca, Bogdan-Tiberius, Volkmann, Katrin, der Maur, Priska Auf, Schmidt, Alexander, Münst, Simone, Sauteur, Loïc, Kloc, Michal, Palafox, Marta, Britschgi, Adrian, Unterreiner, Vincent, Galuba, Olaf, Claerr, Isabelle, Lopez-Romero, Sandra, Galli, Giorgio G., Baeschlin, Daniel, Okamoto, Ryoko, Soysal, Savas D., Mechera, Robert, Weber, Walter P., Radimerski, Thomas, Bentires-Alj, Mohamed

“…Plasticity delineates cancer subtypes with more or less favourable outcomes. In breast cancer, the subtype triple-negative lacks expression of major…”
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Abstract 3305: Hippo kinases LATS1/2 control human breast cell fate by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Brinkhaus, Heike, Pinto Couto, Joana, De Silva, Duvini, Miraglia, Loren, Stadler, Michael B., Orth, Anthony P., Bonamy, Ghislain M.C., Reddy, Venkateshwar A., Bentires-Alj, Mohamed

“…Cellular differentiation and lineage commitment in adult tissues is a tightly regulated, yet highly dynamic process. It is of crucial importance to understand…”
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The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ER by Britschgi, Adrian, Duss, Stephan, Kim, Sungeun, Couto, Joana Pinto, Brinkhaus, Heike, Koren, Shany, De Silva, Duvini, Mertz, Kirsten D, Kaup, Daniela, Varga, Zsuzsanna, Voshol, Hans, Vissieres, Alexandra, Leroy, Cedric, Roloff, Tim, Stadler, Michael B, Scheel, Christina H, Miraglia, Loren J, Orth, Anthony P, Bonamy, Ghislain M. C, Reddy, Venkateshwar A, Bentires-Alj, Mohamed

“…Ablation of the large tumour suppressor kinases 1 and 2 promotes a luminal breast cell phenotype through stabilization of oestrogen receptor-[alpha], thereby…”
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PIK3CA^sup H1047R^ induces multipotency and multi-lineage mammary tumours by Koren, Shany, Reavie, Linsey, Couto, Joana Pinto, De Silva, Duvini, Stadler, Michael B, Roloff, Tim, Britschgi, Adrian, Eichlisberger, Tobias, Kohler, Hubertus, Aina, Olulanu, Cardiff, Robert D, Bentires-Alj, Mohamed

“…The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor…”
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induces multipotency and multi-lineage mammary tumours by Koren, Shany, Reavie, Linsey, Couto, Joana Pinto, De Silva, Duvini, Stadler, Michael B, Roloff, Tim, Britschgi, Adrian, Eichlisberger, Tobias, Kohler, Hubertus, Aina, Olulanu, Cardiff, Robert D, Bentires-Alj, Mohamed

“…The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor…”
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STAT3 negatively regulates thyroid tumorigenesis by Couto, Joana Pinto, Daly, Laura, Almeida, Ana, Knauf, Jeffrey A., Fagin, James A., Sobrinho-Simões, Manuel, Lima, Jorge, Máximo, Valdemar, Soares, Paula, Lyden, David, Bromberg, Jacqueline F.

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Acquisition of BRAF gene mutations is not a requirement for nodal metastasis of papillary thyroid carcinoma by Trovisco, Vítor, Couto, Joana Pinto, Cameselle-Teijeiro, José, De Castro, Inês Vieira, Fonseca, Elsa, Soares, Paula, Sobrinho-Simões, Manuel

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