Metastatic exocrine pancreatic adenocarcinoma in a giant otter (Pteronura brasiliensis)

Neoplasms of the exocrine pancreas are uncommon in domestic animals and rarely occur in wildlife. This article describes the clinical and pathological findings of one case of metastatic exocrine pancreatic adenocarcinoma in an 18-year-old giant otter (Pteronura brasiliensis) in captivity with a hist...

Full description

Saved in:

Bibliographic Details
Published in:	Acta veterinaria Hungarica (Budapest. 1983) Vol. 71; no. 1; p. 41
Main Authors:	Pinto, Maria Helena Barros, Braga, Thiago Rodrigues Cardoso, Blume, Guilherme Reis, Oliveira, Letícia Batelli de, Chagas, Nicolas Thomas Costa das, Souza, Fernanda Rezende, Cassali, Geovanni Dantas, Sant'Ana, Fabiano José Ferreira de
Format:	Journal Article
Language:	English
Published:	Hungary 20-06-2023
Subjects:	Adenocarcinoma - veterinary Animals Otters Pancreatic Neoplasms Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreatic Neoplasms - veterinary pancreatic adenocarcinoma wildlife disease giant otter immunohistochemistry oncology
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Neoplasms of the exocrine pancreas are uncommon in domestic animals and rarely occur in wildlife. This article describes the clinical and pathological findings of one case of metastatic exocrine pancreatic adenocarcinoma in an 18-year-old giant otter (Pteronura brasiliensis) in captivity with a history of inappetence and apathy. Abdominal ultrasonography was inconclusive, and tomography revealed a neoplasm affecting the urinary bladder and hydroureter. During the anaesthesia recovery, the animal presented a cardiorespiratory arrest and died. Grossly, there were neoplastic nodules in the pancreas, urinary bladder, spleen, adrenal glands, and mediastinal lymph node. Microscopically, all nodules were composed of a malignant hypercellular proliferation of epithelial cells with acinar or solid disposition, supported by a sparse fibrovascular stroma. Neoplastic cells were immunolabeled with antibodies to Pan-CK, CK7, CK20, PPP and chromogranin A. Approximately 25% of the cells were positive for the presence of Ki-67 too. Pathological and immunohistochemical findings confirmed the diagnosis of metastatic exocrine pancreatic adenocarcinoma.
ISSN:	0236-6290
DOI:	10.1556/004.2023.00888