Search Results - "Pinto, L I"

Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones by Jarvest, Richard L., Pinto, Ivan L., Ashman, Stephen M., Dabrowski, Christine E., Fernandez, Annabellee V., Jennings, L.John, Lavery, Patrick, Tew, David G.

“…Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency…”
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Non-thiazolidinedione antihyperglycaemic agents. Part 3: the effects of stereochemistry on the potency of α-methoxy-β-phenylpropanoic acids by Haigh, David, Allen, Graham, Birrell, Helen C., Buckle, Derek R., Cantello, Barrie C.C., Eggleston, Drake S., Haltiwanger, R.Curtis, Holder, Julie C., Lister, Carolyn A., Pinto, Ivan L., Rami, Harshad K., Sime, John T., Smith, Stephen A., Sweeney, John D.

“…Rhizopus delemar lipase catalysed ester hydrolysis of the α-methoxy-β-phenylpropanoate 1 affords the ( R)-(+) and ( S)-(−) isomers in >84% enantiomeric excess…”
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Inhibition of human cytomegalovirus protease by enedione derivatives of thieno[2,3-d]oxazinones through a novel dual acylation/alkylation mechanism by Pinto, Ivan L., Jarvest, Richard L., Clarke, Brian, Dabrowski, Christine E., Fenwick, Ashley, Gorczyca, Michele M, Jennings, L.John, Lavery, Patrick, Sternberg, Edmund J, Tew, David G., West, Andrew

“…Enedione derivatives of thieno[2,3-d]oxazinones are nanomolar inhibitors of CMV protease which act through a novel dual acylation of the catalytic serine and…”
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Desenvolvimento de Cerveja Artesanal com Acerola (Malpighia emarginata DC) e Abacaxi (Ananas comosus L. Merril) by Pinto, L. I. F., Zambelli, R. A., Santos Junior, E. C., Pontes, D. F.

“…A cerveja é a bebida alcoólica mais consumida no mundo. Estando bem relacionado com festividades e comemorações, porém essa bebida contém uma variedade de…”
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Natural product derived inhibitors of lipoprotein associated phospholipase A2, synthesis and activity of analogues of SB-253514 by PINTO, I. L, BOYD, H. F, HICKEY, D. M. B

“…The synthesis of analogues of SB-253514, a novel natural product derived inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2), is described together…”
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Synthesis and smooth muscle relaxant activity of a new series of potassium channel activators: 3-amido-1,1-dimethylindan-2-ols by Buckle, Derek R, Arch, Jonathan R. S, Edge, Colin, Foster, Keith A, Houge-Frydrych, Catherine S. V, Pinto, Ivan L, Smith, David G, Taylor, John F, Taylor, Stephen G

“…The synthesis of a novel series of smooth muscle relaxants which have been shown to act via the opening or activation of potassium channels is described…”
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Relaxant activity of 6-cyano-2,2-dimethyl-2H-1-benzopyran-4-carboxamides and -thiocarboxamides and their analogs in guinea pig trachealis by Arch, Jonathan R. S, Buckle, Derek R, Carey, Claire, Parr-Dobrzanski, Hilary, Faller, Andrew, Foster, Keith A, Houge-Frydrych, Catherine S. V, Pinto, Ivan L, Smith, David G, Taylor, Stephen G

“…Structural modifications of the potassium channel activator cromakalim (1) are described in which the amide moiety at C-4 has been replaced by carboxamide and…”
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Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids by Buckle, D.R., Cantello, B.C.C., Cawthorne, M.A., Coyle, P.J., Dean, D.K., Faller, A., Haigh, D., Hindley, R.M., Jefcott, L.J., Lister, C.A., Pinto, I.L., Rami, H.K., Smith, D.G., Smith, S.A.

“…The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised…”
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1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2) by Bloomer, J C, Boyd, H F, Hickey, D M, Ife, R J, Leach, C A, Macphee, C H, Milliner, K J, Pinto, I L, Rawlings, D A, Smith, S A, Stansfield, I G, Stanway, S J, Taylor, M A, Theobald, C J, Whittaker, C M

“…The lipophilic 1-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, inhibitors of recombinant lipoprotein-associated phospholipase A(2), has been…”
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New Quantitative Indicator for Measuring the Quality of Road by Israel Pinto, Leandro, Bertemes Filho, Pedro

“…Visual techniques for qualitative assessment of roads, which rank the roads either good or not, have been widely used by the International Confederation of…”
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Relaxant activity of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans on guinea pig isolated trachealis by Buckle, Derek R, Arch, Jonathon R. S, Fenwick, Ashley E, Houge-Frydrych, Catherine S. V, Pinto, Ivan L, Smith, David G, Taylor, Stephen G, Tedder, John M

“…A series of 4-amido-3,4-dihydro-2H-1-benzopyran-3-ols and 4-amido-2H-1-benzopyrans related to the potassium channel activator cromakalim have been prepared and…”
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Is there a relationship between inborn errors of metabolism and extensive mongolian spots? by Mendez, H M, Pinto, L I, Paskulin, G A, Ricachnevsky, N

“…We report on a case of inborn errors of metabolism in association with extensive mongolian spots. We suggest that this association may be due to a…”
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Dental caries prevention with semestral topical administration of acidulated phosphate fluoride by Pinto, I L

“…998 children aged 6, 8 and 10, from low income families living in the Federal District, Brazil and attending public, first grade, schools, received bi-annual…”
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N-1 substituted pyrimidin-4-ones: Novel, orally active inhibitors of lipoprotein-associated phospholipase A2 by BOYD, Helen F, FELL, Stephen C. M, PORTER, Rod A, RAWLINGS, D. Anthony, SMITH, Stephen A, STANSFIELD, Ian G, TEW, David G, THEOBALD, Colin J, WHITTAKER, Caroline M, FLYNN, Sean T, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L

“…From two related series of 2-(alkylthio)-pyrimidones, a novel series of 1-((amidolinked)-alkyl)-pyrimidones has been designed as nanomolar inhibitors of human…”
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The synthesis of 5-alkoxy and 5-amino substituted thiophenes by Pinto, Ivan L, Jarvest, Richard L, Serafinowska, Halina T

“…5-Alkoxythiophenes have been prepared by an extension of the Gewald thiophene synthesis and a novel four component condensation reaction uncovered by which…”
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The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2 by BOYD, Helen F, HAMMOND, Beverley, STANSFIELD, Ian G, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, SMITH, Stephen A

“…Modification of the pyrimidone 5-substituent in a series of 1-((amidolinked)-alkyl)-pyrimidones, lipophilic inhibitors of lipoprotein-associated phospholipase…”
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Prevenção da cárie dental com aplicações tópicas semestrais de flúor-fosfato acidulato by PINTO, I. L

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Potent, orally active inhibitors of lipoprotein-associated phospholipase A(2): 1-(biphenylmethylamidoalkyl)-pyrimidones by Boyd, Helen F, Fell, Stephen C M, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Macphee, Colin H, Milliner, Kevin J, Pinto, Ivan L, Rawlings, D Anthony, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Theobald, Colin J, Whittaker, Caroline M

“…A series of 1-(biphenylmethylamidoalkyl)-pyrimidones has been designed as nanomolar inhibitors of recombinant lipoprotein-associated phospholipase A(2) with…”
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Acute Lymphoblastic Leukemia with t(1;11)(p32;q23) in a Patient Treated for Osteogenic Sarcoma by Pinto, Laís Izabel Borges, Marczyk, Fabiane F., Brunetto, Algemir L.

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Novel, selective mechanism-based inhibitors of the herpes proteases by Pinto, Ivan L., West, Andrew, Debouck, Christine M., DiLella, Anthony G., Gorniak, Joselina G., O'Donnell, Kevin C., O'Shannessy, Daniel J., Patel, Arunbai, Jarvest, Richard L.

“…A novel class of inhibitor of the herpes proteases acting upon the catalytic apparatus by forming covalent complexes are described. Two new families of…”
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