Search Results - "Pinto, JT"

Integration of mucus and its impact within in vitro setups for inhaled drugs and formulations: Identifying the limits of simple vs. complex methodologies when studying drug dissolution and permeability by Radivojev, Snezana, Kargl, Lukas, Pinto, Joana T., Swedrowska, Magda, Malmlöf, Maria, Meindl, Claudia, Forbes, Ben, Gerde, Per, Paudel, Amrit, Fröhlich, Eleonore

“…[Display omitted] Traditionally, developing inhaled drug formulations relied on trial and error, yet recent technological advancements have deepened the…”
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Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture by Pinto, JT, Qiao, C, Xing, J, Rivlin, RS, Protomastro, ML, Weissler, ML, Tao, Y, Thaler, H, Heston, WD

“…This study investigated whether naturally occurring garlic derivatives and synthetic S-cysteinyl compounds that resemble garlic constituents have…”
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Cancer chemoprevention by garlic and garlic-containing sulfur and selenium compounds by El-Bayoumy, Karam, Sinha, Raghu, Pinto, John T, Rivlin, Richard S

“…As early as 1550 B.C., Egyptians realized the benefits of garlic as a remedy for a variety of diseases. Many epidemiological studies support the protective…”
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Cysteine S-conjugate beta-lyases by Cooper, A J L, Pinto, J T

“…Cysteine S-conjugate beta-lyases are pyridoxal 5'-phosphate-containing enzymes that catalyze beta-elimination reactions with cysteine S-conjugates that possess…”
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Redox-sensitive proteins are potential targets of garlic-derived mercaptocysteine derivatives by Pinto, John T, Krasnikov, Boris F, Cooper, Arthur J L

“…Molecular investigations support existing clinical and epidemiological data that garlic-derived allylsulfides reduce cancer risk. Various allylsulfides can…”
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Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH2-Terminal kinase 1 activation by DANHUA XIAO, PINTO, John T, SOH, Jae-Won, DEGUCHI, Atsuko, GUNDERSEN, Gregg G, PALAZZO, Alexander F, YOON, Jung-Taek, SHIRIN, Haim, WEINSTEIN, I. Bernard

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Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells by Xiao, Danhua, Pinto, John T, Gundersen, Gregg G, Weinstein, I Bernard

“…We previously reported that the garlic-derived compound S -allylmercaptocysteine (SAMC) causes growth inhibition, mitotic arrest, and induction of apoptosis in…”
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Antiproliferative effects of allium derivatives from garlic by Pinto, J T, Rivlin, R S

“…There is increasing evidence that allium derivatives from garlic have significant antiproliferative actions on human cancers. Both hormone-responsive and…”
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Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells by PINTO, J. T, SUFFOLETTO, B. P, BERZIN, T. M, CHANG HONG QIAO, LIN, S, TONG, W. P, MAY, F, MUKHERJEE, B, HESTON, W. D. W

“…A novel monoclonal antibody has been developed that reacts strongly with human prostatic cancer, especially tumors of high grade. This antibody (7E11C-5) is…”
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Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen/NAALADase/folate hydrolase by Bacich, D J, Pinto, J T, Tong, W P, Heston, W D

“…Human Prostate Specific Membrane Antigen (PSMA), also known as folate hydrolase I (FOLH1), is a 750-amino acid type II membrane glycoprotein, which is…”
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Treatment of YAC128 mice and their wild‐type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease by Pinto, John T., Van Raamsdonk, Jeremy M., Leavitt, Blair R., Hayden, Michael R., Jeitner, Thomas M., Thaler, Howard T., Krasnikov, Boris F., Cooper, Arthur J. L.

“…Cystamine is beneficial to Huntington disease (HD) transgenic mice. To elucidate the mechanism, cystamine metabolites were determined in brain and plasma of…”
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Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide by SHIRIN, Haim, PINTO, John T, KAWABATA, Yuichi, SOH, Jae-Won, DELOHERY, Thomas, MOSS, Steven F, MURTY, Vundavalli, RIVLIN, Richard S, HOLT, Peter R, WEINSTEIN, I. Bernard

“…Epidemiological studies link increased garlic (Allium sativum) consumption with a reduced incidence of colon cancer in various human populations. Experimental…”
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Helicobacter pylori decreases gastric mucosal glutathione by Shirin, Haim, Pinto, John T., Liu, Lawrence U., Merzianu, Mihai, Sordillo, Emilia Mia, Moss, Steven F.

“…Activation of oxidative stress pathways may contribute to gastric epithelial damage and mutagenesis caused by Helicobacter pylori. We measured the effect of H…”
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Slow Motion Manifolds Far from the Attractor in Multistable Reaction–Diffusion Equations by Pinto, João T.

“…We consider a scalar reaction–diffusion equation with multistable nonlinearity with a particular symmetry. By reduction to a family of transmission problems in…”
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The risk of vulnerable failure by Pinto, J.T, Blockley, D.I, Woodman, N.J

“…There is, as yet, no generally accepted theory of structural robustness or of its corollary, structural vulnerability. The theory of structural vulnerability…”
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Alterations of prostate biomarker expression and testosterone utilization in human LNCaP prostatic carcinoma cells by garlic-derived S-allylmercaptocysteine by Pinto, John Thomas, Qiao, Changhong, Xing, Jie, Suffoletto, Brian P., Schubert, Kristin B., Rivlin, Richard S., Huryk, Robert F., Bacich, Dean J., Heston, Warren D.W.

“…BACKGROUND This study determined the effects of S‐allylmercaptocysteine (SAMC), a phytoconstituent from garlic, on the expression of androgen‐responsive…”
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Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma by Wolchok, Jedd D, Williams, Linda, Pinto, John T, Fleisher, Martin, Krown, Susan E, Hwu, Wen-Jen, Livingston, Philip O, Chang, Christine, Chapman, Paul B

“…Reduced glutathione (GSH) production by tumour cells has been proposed as a mechanism for resistance to alkylating agents. High levels of paracetamol can…”
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Influence of clinical factors, drug use, and food intake on the glutathione system by Shirin, H, Pinto, J T, Moss, S F

“…H pylori is well known to induce formation of reactive oxygen species (ROS), particularly in the antrum, 4 and result in oxidative damage to DNA. 5…”
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Relationship of glutathione and glutathione-S-transferase to cisplatin sensitivity in human head and neck squamous carcinoma cell lines by Yellin, S A, Davidson, B J, Pinto, J T, Sacks, P G, Qiao, C, Schantz, S P

“…Factors controlling glutathione metabolism may govern sensitivity to chemotherapeutic agents such as cisplatin. Using a battery of cell lines derived from…”
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The importance of classical geodetic observations for analyzing the geodynamic behaviour of the Açores archipelago by Pagarete, J, Teixeira Pinto, J, Mendes, V.B, Antunes, C, Ribeiro, H

“…Despite their relative poor precision, classical geodetic observations can provide valuable information about tectonic displacements because their lack of…”
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