Real-world data lipid profiles in one million colombian adults: The LiPAC million person study

Lipid profile results are of clinical interest for assessing the presence of dyslipidemia and the risk of cardiovascular disease. This study aimed to characterize lipid profile parameters in a large adult population from different regions of Colombia. Cross-sectional study. Adults with a complete li...

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Published in:	Atherosclerosis plus Vol. 58; pp. 51 - 58
Main Authors:	Colmenares-Mejía, Claudia C., Godoy-Corredor, Marcela, Morales-Mendoza, Esteban, Pinto-Pinzón, Diego Alejandro, Rozo-Vanstrahlen, José Medardo, Acuña-Olmos, Jairo, Hilarión-Gaitán, Liliana, Suarez-Ramos, María del Pilar, Ruiz-Amaya, Diego Alberto, Salazar-Heredia, Fredy Rolando, Vargas-Rodríguez, Johana, Isaza-Ruget, Mario A.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-12-2024
Subjects:	Cardiovascular diseases Cholesterol Cholesterol, HDL Cholesterol, LDL Lipids Risk factors Triglycerides Cholesterol, HDL Lipids Cholesterol, LDL Triglycerides Cardiovascular diseases Risk factors Cholesterol
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Summary:	Lipid profile results are of clinical interest for assessing the presence of dyslipidemia and the risk of cardiovascular disease. This study aimed to characterize lipid profile parameters in a large adult population from different regions of Colombia. Cross-sectional study. Adults with a complete lipid profile [TC, c-HDL, non-c-HDL, c-LDL, Triglycerides] from a national reference laboratory between 2018 and 2022 were included. Lipid profile levels are reported as medians and adjusted means and are also presented according to different guideline thresholds. Mixed dyslipidemia frequencies are also reported. 1,030,195 subjects were included, with a median age of 49 years (IQR 36–61 years); 59.8 % were females. Adjusted mean value for TC was 188.1 mg/dl (CI95 % 188.0–188.2), 110.1 mg/dl (CI95 % 110.0–110.1) for c-LDL, 45.9 mg/dl (CI95 % 45.9–46.0) for c-HDL, 139.1 mg/dl (CI95 % 139.0–139.2) for non-c-HDL and 129.5 mg/dl (CI95 % 129.4–129.6) for triglycerides. The most frequent single dyslipidemia was c-HDL <40 mg/dL (n = 86,725, 8.4 %), and the most common mixed dyslipidemia was TC ≥ 200 mg/dL + c-LDL >130 mg/dL (n = 138,366, 17.0 %). Elevated c-LDL (≥130 mg/dL) was found in 32.4 % of the population, while c-LDL levels ≥190 mg/dL were observed in 2.0 % (n = 21,045). Triglyceride levels ≥500 mg/dL were identified in 0.3 % (n = 3103). This large study on lipid markers from a selected sample of Colombian adults’ highlights variations in dyslipidemia by gender, age, and region. The findings emphasize the need for targeted interventions to reduce cardiovascular risk. Identifying high-risk groups is essential to improving outcomes in developing countries. [Display omitted] •Lipid biomarkers (TC, HDL, Triglycerides, LDL) are studied in a million Colombian adults.•Median HDL was higher in women, while triglycerides were higher in men.•The highest value of triglycerides was observed in young male (<40 years).•Elevated c-LDL (≥130 mg/dL) was found in 32.4 %, while low c-HDL (<40 mg/dL) in 30.1 %.•Understanding lipid profiles in this population is key for cardiovascular risk assessment.
ISSN:	2667-0895 2667-0895
DOI:	10.1016/j.athplu.2024.11.001