Search Results - "Pinto, C N"

A systematic evaluation of normalization methods and probe replicability using infinium EPIC methylation data by Welsh, H, Batalha, C M P F, Li, W, Mpye, K L, Souza-Pinto, N C, Naslavsky, M S, Parra, E J

“…The Infinium EPIC array measures the methylation status of > 850,000 CpG sites. The EPIC BeadChip uses a two-array design: Infinium Type I and Type II probes…”
Get full text

DNA repair, mitochondria, and neurodegeneration by Weissman, L, de Souza-Pinto, N.C, Stevnsner, T, Bohr, V.A

“…Abstract Accumulation of nuclear and mitochondrial DNA damage is thought to be particularly deleterious in post-mitotic cells, which cannot be replaced through…”
Get full text

role of mitochondrial DNA damage in the citotoxicity of reactive oxygen species by Costa, R. A. P, Romagna, C. D, Pereira, J. L, Souza-Pinto, N. C

“…Mitochondria contain their own genome, a small circular molecule of around 16.5 kbases. The mitochondrial DNA (mtDNA) encodes for only 13 polypeptides, but its…”
Get full text

Covid-19 vaccine dissemination: A public health ethical evaluation of Pennsylvania’s plan during Phase 1A by Richardson, CL, Wright, MS, Pinto, CN

Get full text

Care seek behavior for low back pain in southern Brazil during the COVID-19 pandemic: a panel data analysis by Caputo, Eduardo L, Feter, Natan, Pinto, Ricardo N C, Delpino, Felipe Mendes, Cassuriaga, Júlia, da Silva, Carine N, Leite, Jayne S, Jerônimo, Jeferson S, da Silva, Sophia D P, Reichert, Felipe F, Rombaldi, Airton J, da Silva, Marcelo C

“…During the COVID-19 pandemic, people with low back pain (LBP) might have avoided seeking care for their pain. We aimed to investigate how the COVID-19 pandemic…”
Get full text

Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis by Panduri, V., Liu, G., Surapureddi, S., Kondapalli, J., Soberanes, S., de Souza-Pinto, N.C., Bohr, V.A., Budinger, G.R.S., Schumacker, P.T., Weitzman, S.A., Kamp, D.W.

“…8-Oxoguanine DNA glycosylase (Ogg1) repairs 8-oxo-7,8-dihydroxyguanine (8-oxoG), one of the most abundant DNA adducts caused by oxidative stress. In the…”
Get full text

Periosteal Fixation Procedures in the Management of Incomitant Strabismus by Saxena, Rohit, Phuljhele, Swati, Sharma, Pradeep, Pinto, C N

“…Managing a case of incomitant strabismus from nerve palsy or extraocular muscle loss is a major challenge. Among possible management options are globe or…”
Get full text

No evidence of mitochondrial respiratory dysfunction in OGG1-null mice deficient in removal of 8-oxodeoxyguanine from mitochondrial DNA by Stuart, J.A., Bourque, B.M., de Souza-Pinto, N.C., Bohr, V.A.

“…Accumulation of high levels of mutagenic oxidative mitochondrial DNA (mtDNA) lesions like 8-oxodeoxyguanine (8-oxodG) is thought to be involved in the…”
Get full text

Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction by Stuart, Jeff A., Karahalil, Bensu, Hogue, Barbara A., Souza‐Pinto, Nadja C., Bohr, Vilhelm A.

“…Aging is strongly correlated with the accumulation of oxidative damage in DNA, particularly in mitochondria. Oxidative damage to both mitochondrial and nuclear…”
Get full text

Localization of mitochondrial DNA base excision repair to an inner membrane-associated particulate fraction by Stuart, J. A., Mayard, S., Hashiguchi, K., Souza-Pinto, N. C., Bohr, V. A.

“…Mitochondrial DNA (mtDNA) contains high levels of oxidative damage relative to nuclear DNA. A full, functional DNA base excision repair (BER) pathway is…”
Get full text

Age-associated increase in 8-oxo-deoxyguanosine glycosylase/AP lyase activity in rat mitochondria by Souza-Pinto, Nadja C., Croteau, Deborah L., Hudson, Edgar K., Hansford, Richard G., Bohr, Vilhelm A.

“…The mitochondrial theory of aging postulates that organisms age due to the accumulation of DNA damage and mutations in the multiple mitochondrial genomes,…”
Get full text

Increased H2O2 levels and p53 stabilization lead to mitochondrial dysfunction in XPC-deficient cells by Freire, T S, Mori, M P, Miranda, J N F A, Muta, L Y M, Machado, F T, Moreno, N C, Souza-Pinto, N C

“…Abstract XPC deficiency is associated with mitochondrial dysfunction, increased mitochondrial H2O2 production and sensitivity to the Complex III inhibitor…”
Get full text

Thermal and Acoustic Performance of Green Polyethylene/Cork Composite for Civil Construction Applications by Vasconcelos, Gabriela Celso Melo Soares de, Carvalho, Laura Hecker, Araújo, Frederico H., Pinto, Fernando A. N. C., Barbosa, Renata, Santos, Maria do Socorro Ferreira dos, Alves, Tatianny Soares

“…In this study, green high-density polyethylene (GHDPE) composites with 5, 10 and 15% natural powdered cork (CP) with and without 5% maleic anhydride (PE-g-MA)…”
Get full text

DNA base excision repair activities and pathway function in mitochondrial and cellular lysates from cells lacking mitochondrial DNA by Stuart, J.A., Hashiguchi, K., Wilson, D.M., Copeland, W.C., Souza‐Pinto, N.C., Bohr, V.A.

“…Mitochondrial DNA (mtDNA) contains higher steady‐state levels of oxidative damage and mutates at rates significantly greater than nuclear DNA. Oxidative…”
Get full text

Validation and calibration of the patient-reported outcomes measurement information system: Pediatric PROMIS® Emotional Distress domain item banks, Portuguese version (Brazil/Portugal) by Pinto, Márcia N. F. de C., Pinto, Rogério de M. C., Mendonça, Tânia M. da S., Souza, Camilla G., da Silva, Carlos Henrique M.

“…Objective This paper goal was to validate the Portuguese version (Brazil/Portugal) of the Anger, Anxiety, and Depressive Symptoms item banks of the Pediatric…”
Get full text

Mechanisms of Manganese-Induced Neurotoxicity in Primary Neuronal Cultures: The Role of Manganese Speciation and Cell Type by Hernández, R. B., Farina, M., Espósito, B. P., Souza-Pinto, N. C., Barbosa, F., Suñol, C.

“…Manganese (Mn) is an essential trace element required for the proper functioning of a variety of physiological processes. However, chronic exposures to Mn can…”
Get full text

Age-associated change in mitochondrial DNA damage by Hudson, E K, Hogue, B A, Souza-Pinto, N C, Croteau, D L, Anson, R M, Bohr, V A, Hansford, R G

“…There is an age-associated decline in the mitochondrial function of the Wistar rat heart. Previous reports from this lab have shown a decrease in mitochondrial…”
Get more information

Repair of 8-oxodeoxyguanosine lesions in mitochondrial DNA depends on the oxoguanine DNA glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial DNA of OGG1-defective mice by DE SOUZA-PINTO, Nadja C, EIDE, Lars, HOGUE, Barbara A, THYBO, Tanja, STEVNSNER, Tinna, SEEBERG, Erling, KLUNGLAND, Arne, BOHR, Vilhelm A

“…Mitochondria are not only the major site for generation of reactive oxygen species, but also one of the main targets of oxidative damage. One of the major…”
Get full text

Spectrochemical analysis of seasonal and sexual variation of antioxidants in Corema album (L.) D. Don leaf extracts by Silva, Daniela J.S., Santos, João A.V., Pinto, Joana C.N., Llorent-Martínez, Eulogio J., Castilho, Paula C., Batista de Carvalho, Luís A.E., Marques, Maria Paula M., Barroca, Maria João, Moreira da Silva, Aida, da Costa, Ricardo M.F.

“…[Display omitted] •Antioxidant activity is higher in male plants and in the later harvests.•Phenolic structure and abundance explain the observed differences…”
Get full text

Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c by Kirsch, David G., Doseff, Andrea, Chau, B. Nelson, Lim, Dae-Sik, de Souza-Pinto, Nadja C., Hansford, Richard, Kastan, Michael B., Lazebnik, Yuri A., Hardwick, J. Marie

“…Caspases are cysteine proteases that mediate apoptosis by proteolysis of specific substrates. Although many caspase substrates have been identified, for most…”
Get full text