Search Results - "Pintar, J E"

Essential role of mu opioid receptor in the regulation of delta opioid receptor–mediated antihyperalgesia by Gendron, L, Pintar, J.E, Chavkin, C

“…Abstract Analgesic effects of delta opioid receptor (DOR) –selective agonists are enhanced during persistent inflammation and arthritis. Although the…”
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Nociception increases during opioid infusion in opioid receptor triple knock-out mice by Juni, A, Klein, G, Pintar, J.E, Kest, B

“…Abstract Opioids are extensively used analgesics yet can paradoxically increase pain sensitivity in humans and rodents. This hyperalgesia is extensively…”
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The absence of endogenous β-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation by Petraschka, M, Li, S, Gilbert, T.L, Westenbroek, R.E, Bruchas, M.R, Schreiber, S, Lowe, J, Low, M.J, Pintar, J.E, Chavkin, C

“…Abstract Phosphorylation of specific sites in the second intracellular loop and in the C-terminal domain have previously been suggested to cause…”
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Reversal of Physiological Deficits Caused by Diminished Levels of Peptidylglycine α-Amidating Monooxygenase by Dietary Copper by Bousquet-Moore, D, Ma, X. M, Nillni, E. A, Czyzyk, T. A, Pintar, J. E, Eipper, B. A, Mains, R. E

“…Amidated peptides are critically involved in many physiological functions. Genetic deletion of peptidylglycine α-amidating monooxygenase (PAM), the only enzyme…”
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Loss of the mu opioid receptor induces strain-specific alterations in hippocampal neurogenesis and spatial learning by Cominski, T.P, Ansonoff, M.A, Turchin, C.E, Pintar, J.E

“…Highlights • MOR-1 KO mice exhibit background strain-dependent alterations in cell survival in the DG. • MOR-1 KO mice exhibit strain-dependent alterations in…”
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Loss of the mu opioid receptor on different genetic backgrounds leads to increased bromodeoxyuridine labeling in the dentate gyrus only after repeated injection by Cominski, T.P, Turchin, C.E, Hsu, M.S, Ansonoff, M.A, Pintar, J.E

“…Abstract The endogenous opioid system is involved in various physiological processes, including neurogenesis in the dentate gyrus (DG) of the hippocampus. In…”
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Defective Prodynorphin Processing in Mice Lacking Prohormone Convertase PC2 by Berman, Y., Mzhavia, N., Polonskaia, A., Furuta, M., Steiner, D. F., Pintar, J. E., Devi, L. A.

“…: Prodynorphin, a multifunctional precursor of several important opioid peptides, is expressed widely in the CNS. It is processed at specific single and paired…”
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Increased gabaergic input to ventral tegmental area dopaminergic neurons associated with decreased cocaine reinforcement in μ-opioid receptor knockout mice by Mathon, D.S., Lesscher, H.M.B., Gerrits, M.A.F.M., Kamal, A., Pintar, J.E., Schuller, A.G.P., Spruijt, B.M., Burbach, J.P.H., Smidt, M.P., van Ree, J.M., Ramakers, G.M.J.

“…There is general agreement that dopaminergic neurons projecting from the ventral tegmental area (VTA) to the nucleus accumbens and prefrontal cortex play a key…”
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Mortality in 7B2 Null Mice Can Be Rescued by Adrenalectomy: Involvement of Dopamine in ACTH Hypersecretion by Laurent, V., Kimble, A., Peng, B., Zhu, P., Pintar, J. E., Steiner, D. F., Lindberg, I.

“…The serine protease prohormone convertase 2 (PC2), principally involved in the processing of polypeptide hormone precursors in neuroendocrine tissues, requires…”
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Genetic and pharmacological manipulation of μ opioid receptors in mice reveals a differential effect on behavioral sensitization to cocaine by Hummel, M, Ansonoff, M.A, Pintar, J.E, Unterwald, E.M

“…Cocaine-induced behavioral sensitization is a complex phenomenon involving a number of neuromodulator and neurotransmitter systems. To specifically investigate…”
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Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors by JUNG, M.-Y, SKRYABIN, B. V, ARAI, M, ABBONDANZO, S, FU, D, BROSIUS, J, ROBAKIS, N. K, POLITES, H. G, PINTAR, J. E, SCHMAUSS, C

“…Within the D2-class of dopamine receptors, the D2 and D3 subtypes share the highest degree of similarity in their primary structure. However, the extent to…”
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Morphine tolerance and dependence in nociceptin/orphanin fq transgenic knock-out mice by Kest, B., Hopkins, E., Palmese, C.A., Chen, Z.P., Mogil, J.S., Pintar, J.E.

“…It has been hypothesized that morphine tolerance and dependence in mice following chronic exposure may reflect increased compensatory activity of antiopioid…”
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Expression of VGF mRNA in developing neuroendocrine and endocrine tissues by Snyder, SE, Peng, B, Pintar, JE, Salton, SR

“…Analysis of knockout mice suggests that the neurotropin-inducible secreted polypeptide VGF (non-acronymic) plays an important role in the regulation of energy…”
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Improgan, a cimetidine analog, induces morphine-like antinociception in opioid receptor-knockout mice by Hough, L.B., Nalwalk, J.W., Chen, Y., Schuller, A., Zhu, Y., Zhang, J., Menge, W.M.P.B., Leurs, R., Timmerman, H., Pintar, J.E.

“…Improgan is an analog of the H 2 antagonist cimetidine that does not act on known histamine receptors, but induces highly effective analgesia in rodents…”
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Localization of opioid receptor antagonist [ 3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sites by Gackenheimer, S.L., Suter, T.M., Pintar, J.E., Quimby, S.J., Wheeler, W.J., Mitch, C.H., Gehlert, D.R., Statnick, M.A.

“…Agonist stimulation of opioid receptors increases feeding in rodents, while opioid antagonists inhibit food intake. The pan-opioid antagonist, LY255582,…”
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Nociceptin/orphanin FQ knockout mice display up-regulation of the opioid receptor-like 1 receptor and alterations in opioid receptor expression in the brain by Clarke, S., Chen, Z., Hsu, M.-S., Hill, R.G., Pintar, J.E., Kitchen, I.

“…The opioid receptor-like 1 receptor is a novel member of the opioid receptor family and its endogenous peptide ligand has been termed nociceptin and orphanin…”
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Transiently catecholaminergic (TC) cells in the bowel of the fetal rat: Precursors of noncatecholaminergic enteric neurons by Baetge, G., Pintar, J.E., Gershon, M.D.

“…Experiments were done to study the fate of transient catecholaminergic (TC) cells that develop in the rodent gut during ontogeny. When they are first detected,…”
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μ‐opioid receptor modulation of calcium channel current in periaqueductal grey neurons from C57B16/J mice and mutant mice lacking MOR‐1 by Connor, Mark, Schuller, Alwin, Pintar, John E, Christie, MacDonald J

“…The actions of opioid receptor agonists on the calcium channel currents (IBa) of acutely dissociated periaqueductal grey (PAG) neurons from C57B16/J mice and…”
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Distinct expression patterns of insulin-like growth factor binding proteins 2 and 5 during fetal and postnatal development by Green, B N, Jones, S B, Streck, R D, Wood, T L, Rotwein, P, Pintar, J E

“…Insulin-like growth factors (IGFs), when isolated from serum or tissue fluids, are usually found as part of a protein complex which also contains one of…”
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The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity by Zheng, M, Streck, RD, Scott, RE, Seidah, NG, Pintar, JE

“…The genes encoding mammalian subtilisin-like endoproteases furin, PC1, and PC2 have been isolated and are implicated in endoproteolytic cleavage of precursor…”
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