Search Results - "Pinon, Grégory M."

The synthetic androgen methyltrienolone (r1881) acts as a potent antagonist of the mineralocorticoid receptor by Takeda, Armelle-Natsuo, Pinon, Grégory M, Bens, Marcelle, Fagart, Jérôme, Rafestin-Oblin, Marie-Edith, Vandewalle, Alain

“…Aldosterone binds to the mineralocorticoid receptor (MR) and exerts fine control over Na+ absorption in renal collecting duct cells (CCDs). Many natural and…”
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Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension by Fagart, Jérôme, Huyet, Jessica, Pinon, Grégory M, Rochel, Marina, Mayer, Claudine, Rafestin-Oblin, Marie-Edith

“…The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist…”
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Structural basis of spirolactone recognition by the mineralocorticoid receptor by Huyet, Jessica, Pinon, Grégory M, Fay, Michel R, Fagart, Jérôme, Rafestin-Oblin, Marie-Edith

“…Spirolactones are potent antagonists of the mineralocorticoid receptor (MR), a ligand-induced transcription factor belonging to the nuclear receptor…”
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Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction by Ozeir, Mohammad, Huyet, Jessica, Burgevin, Marie-Claude, Pinson, Benoît, Chesney, Françoise, Remy, Jean-Marc, Siddiqi, Abdul Rauf, Lupoli, Roland, Pinon, Grégory M., Saint-Marc, Christelle, Gibert, Jean-François, Morales, Renaud, Ceballos-Picot, Irène, Barouki, Robert, Daignan-Fornier, Bertrand, Olivier-Bandini, Anne, Augé, Franck, Nioche, Pierre

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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure by Bucher, Simon, Le Guillou, Dounia, Allard, Julien, Pinon, Grégory M., Begriche, Karima, Tête, Arnaud, Sergent, Odile, Lagadic-Gossmann, Dominique, Fromenty, Bernard

“…Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients. Recently, we showed in…”
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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure by Bucher, Simon, Le Guillou, Dounia, Allard, Julien, Pinon, Grégory M., Begriche, Karima, Tête, Arnaud, Sergent, Odile, Lagadic-Gossmann, Dominique, Fromenty, Bernard

“…Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients. Recently, we showed in…”
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Dehydroepiandrosterone and its 7-hydroxylated metabolites do not interfere with the transactivation and cellular trafficking of the glucocorticoid receptor by Muller, Caroline, Cluzeaud, Françoise, Pinon, Gregory M., Rafestin-Oblin, Marie-Edith, Morfin, Robert

“…The human brain is a target tissue for glucocorticoids (GC). Dehydroepiandrosterone (DHEA) is a neurosteroid produced in the brain where it is transformed into…”
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Possible Involvement of Mitochondrial Dysfunction and Oxidative Stress in a Cellular Model of NAFLD Progression Induced by Benzo[a]pyrene/Ethanol CoExposure by Fromenty, Bernard, Lagadic-Gossmann, Dominique, Tête, Arnaud, Begriche, Karima, Pinon, Grégory, Allard, Julien, Le Guillou, Dounia, Bucher, Simon, Sergent, Odile

“…Exposure to xenobiotics could favor the transition of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis in obese patients. Recently, we showed in…”
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Structural basis for substrate selectivity and nucleophilic substitution mechanisms in human adenine phosphoribosyltransferase catalyzed reaction by Ozeir, Mohammad, Huyet, Jessica, Burgevin, Marie-Claude, Pinson, Benoît, Chesney, Françoise, Remy, Jean-Marc, Siddiqi, Abdul Rauf, Lupoli, Roland, Pinon, Grégory, Saint-Marc, Christelle, Gibert, Jean-François, Morales, Renaud, Ceballos-Picot, Irène, Barouki, Robert, Daignan-Fornier, Bertrand, Olivier-Bandini, Anne, Augé, Franck, Nioche, Pierre

“…The reversible adenine phosphoribosyltransferase enzyme (APRT) is essential for purine homeostasis in prokaryotes and eukaryotes. In humans, APRT (hAPRT) is…”
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Role of CD95‐activated caspase‐1 processing of IL‐1β in TCR‐mediated proliferation of HIV‐infected CD4+ T cells by Petit, Frédéric, Corbeil, Jacques, Lelièvre, Jean‐Daniel, Parseval, Laure Moutouh‐de, Pinon, Grégory, Green, Douglas R., Ameisen, Jean Claude, Estaquier, Jérôme

“…CD95 plays a critical role in the homeostasis of the immune system, and has been reported to participate in T cell death during HIV infection. Here we report…”
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The Severe Form of Hypertension Caused by the Activating S810L Mutation in the Mineralocorticoid Receptor Is Cortisone Related by Rafestin-Oblin, Marie-Edith, Souque, Anny, Bocchi, Brigitte, Pinon, Gregory, Fagart, Jerome, Vandewalle, Alain

“…A gain of function mutation resulting in the substitution of leucine for serine at codon 810 (S810L) in the human mineralocorticoid receptor (MR) is…”
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