Search Results - "Pinon, Delia I."

Transmembrane Segment IV Contributes a Functionally Important Interface for Oligomerization of the Class II G Protein-coupled Secretin Receptor by Harikumar, Kaleeckal G., Pinon, Delia I., Miller, Laurence J.

“…Oligomerization of the Class II G protein-coupled secretin receptor has been reported, but the molecular basis for this and its functional significance have…”
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Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery by Harikumar, Kaleeckal G, Wootten, Denise, Pinon, Delia I, Koole, Cassandra, Ball, Alicja M, Furness, Sebastian G. B, Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J, Sexton, Patrick M

“…The glucagon-like peptide-1 receptor (GLP-1R) is a family B G protein-coupled receptor and an important drug target for the treatment of type II diabetes, with…”
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Molecular Basis of Glucagon-like Peptide 1 Docking to Its Intact Receptor Studied with Carboxyl-terminal Photolabile Probes by Chen, Quan, Pinon, Delia I., Miller, Laurence J., Dong, Maoqing

“…The glucagon-like peptide 1 (GLP1) receptor is a member of Family B G protein-coupled receptors and represents an important drug target for type 2 diabetes…”
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Spatial approximation between secretin residue five and the third extracellular loop of its receptor provides new insight into the molecular basis of natural agonist binding by Dong, Maoqing, Lam, Polo C-H, Pinon, Delia I, Sexton, Patrick M, Abagyan, Ruben, Miller, Laurence J

“…The amino terminus of class II G protein-coupled receptors plays an important role in ligand binding and receptor activation. Understanding of the conformation…”
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Possible endogenous agonist mechanism for the activation of secretin family G protein-coupled receptors by Dong, Maoqing, Pinon, Delia I, Asmann, Yan W, Miller, Laurence J

“…The class B family of G protein-coupled receptors contains several potentially important drug targets, yet our understanding of the molecular basis of ligand…”
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Elucidation of the Molecular Basis of Cholecystokinin Peptide Docking to Its Receptor Using Site-Specific Intrinsic Photoaffinity Labeling and Molecular Modeling by Dong, Maoqing, Lam, Polo C.-H, Pinon, Delia I, Abagyan, Ruben, Miller, Laurence J

“…G protein-coupled receptors represent the largest family of receptors and the major target of current drug development efforts. Understanding of the mechanisms…”
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Spatial Approximation between the Amino Terminus of a Peptide Agonist and the Top of the Sixth Transmembrane Segment of the Secretin Receptor by Dong, Maoqing, Li, Zhijun, Pinon, Delia I., Lybrand, Terry P., Miller, Laurence J.

“…Distinct spatial approximations between residues within the secretin pharmacophore and its receptor can provide important constraints for modeling this…”
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Fluorescent Indicators Distributed throughout the Pharmacophore of Cholecystokinin Provide Insights into Distinct Modes of Binding and Activation of Type A and B Cholecystokinin Receptors by Harikumar, Kaleeckal G., Pinon, Delia I., Miller, Laurence J.

“…Ligand probes with fluorescent indicators positioned throughout the pharmacophoric domain can provide important insights into the molecular basis of receptor…”
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Molecular approximations between residues 21 and 23 of secretin and its receptor: development of a model for peptide docking with the amino terminus of the secretin receptor by Dong, Maoqing, Lam, Polo C-H, Gao, Fan, Hosohata, Keiko, Pinon, Delia I, Sexton, Patrick M, Abagyan, Ruben, Miller, Laurence J

“…The structurally unique amino-terminal domain of class II G protein-coupled receptors is critically important for ligand binding and receptor activation…”
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Molecular Approximation between a Residue in the Amino-terminal Region of Calcitonin and the Third Extracellular Loop of the Class B G Protein-coupled Calcitonin Receptor by Dong, Maoqing, Pinon, Delia I, Cox, Richard F, Miller, Laurence J

“…The calcitonin receptor is a member of the class B family of G protein-coupled receptors, which contains numerous potentially important drug targets…”
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Use of Probes with Fluorescence Indicator Distributed throughout the Pharmacophore to Examine the Peptide Agonist-binding Environment of the Family B G Protein-coupled Secretin Receptor by Harikumar, Kaleeckal G., Hosohata, Keiko, Pinon, Delia I., Miller, Laurence J.

“…Fluorescence techniques can provide insight into the environment of fluorescence indicators situated at distinct sites within a ligand as it is bound to its…”
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Distinct Molecular Mechanisms for Agonist Peptide Binding to Types A and B Cholecystokinin Receptors Demonstrated Using Fluorescence Spectroscopy by Harikumar, Kaleeckal G., Clain, Jeremy, Pinon, Delia I., Dong, Maoqing, Miller, Laurence J.

“…Fluorescence spectroscopy provides a direct method for evaluating the environment of a fluorescent ligand bound to its receptor. We utilized this methodology…”
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Environment and Mobility of a Series of Fluorescent Reporters at the Amino Terminus of Structurally Related Peptide Agonists and Antagonists Bound to the Cholecystokinin Receptor by Harikumar, Kaleeckal G., Pinon, Delia I., Wessels, William S., Prendergast, Franklyn G., Miller, Laurence J.

“…Fluorescence is a powerful biophysical tool for the analysis of the structure and dynamics of proteins. Here, we have developed two series of new fluorescent…”
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Spatial Approximations between Residues 6 and 12 in the Amino-terminal Region of Glucagon-like Peptide 1 and Its Receptor: A REGION CRITICAL FOR BIOLOGICAL ACTIVITY by Chen, Quan, Pinon, Delia I, Miller, Laurence J, Dong, Maoqing

“…Understanding the molecular basis of natural ligand binding and activation of the glucagon-like peptide 1 (GLP1) receptor may facilitate the development of…”
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Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor by Ding, Xi-Qin, Pinon, Delia I, Furse, Kristina E, Lybrand, Terry P, Miller, Laurence J

“…Insight into the molecular basis of cholecystokinin (CCK) binding to its receptor has come from receptor mutagenesis and photoaffinity labeling studies, with…”
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Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling by Miller, Laurence J., Chen, Quan, Lam, Polo C.-H., Pinon, Delia I., Sexton, Patrick M., Abagyan, Ruben, Dong, Maoqing

“…The glucagon-like peptide 1 (GLP1) receptor is an important drug target within the B family of G protein-coupled receptors. Its natural agonist ligand, GLP1,…”
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Spatial approximation between a photolabile residue in position 13 of secretin and the amino terminus of the secretin receptor by Zang, Mengwei, Dong, Maoqing, Pinon, Delia I, Ding, Xi-Qin, Hadac, Elizabeth M, Li, Zhijun, Lybrand, Terry P, Miller, Laurence J

“…The amino-terminal domain of class B G protein-coupled receptors is critically important for natural peptide agonist binding and action. The precise role it…”
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Demonstration of a specific site of covalent labeling of the human motilin receptor using a biologically active photolabile motilin analog by Matsuura, Bunzo, Dong, Maoqing, Coulie, Bernard, Pinon, Delia I, Miller, Laurence J

“…The motilin receptor belongs to a group of class I G protein-coupled receptors that also includes the growth hormone secretagogue and ghrelin receptors. These…”
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Key differences in molecular complexes of the cholecystokinin receptor with structurally related peptide agonist, partial agonist, and antagonist by Arlander, Sonnet J H, Dong, Maoqing, Ding, Xi-Qin, Pinon, Delia I, Miller, Laurence J

“…The molecular basis of docking of receptor ligands having differences in biological activity and their subsequent effects on receptor conformation represent…”
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Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping by Dong, Maoqing, Xu, Xiequn, Ball, Alicja M., Makhoul, Joshua A., Lam, Polo C.‐H., Pinon, Delia I., Orry, Andrew, Sexton, Patrick M., Abagyan, Ruben, Miller, Laurence J.

“…While it is evident that the carboxyl‐terminal region of natural peptide ligands bind to the amino‐terminal domain of class B GPCRs, how their biologically…”
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