Search Results - "Pinnock, R D"

Gabapentin inhibits high‐threshold calcium channel currents in cultured rat dorsal root ganglion neurones by Sutton, K G, Martin, D J, Pinnock, R D, Lee, K, Scott, R H

“…This study examined the action of gabapentin (gabapentin,1‐(aminomethyl) cyclohexane acetic acid (Neurontin®)) on voltage‐gated calcium (Ca2+) channel influx…”
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Identification of MEK1 as a novel target for the treatment of neuropathic pain by Ciruela, A, Dixon, A K, Bramwell, S, Gonzalez, M I, Pinnock, R D, Lee, K

“…In the present study we have attempted to identify changes in gene expression which are associated with neuropathic pain using subtractive suppression…”
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Cellular and molecular action of the putative GABA-mimetic, gabapentin by Maneuf, Y P, Gonzalez, M I, Sutton, K S, Chung, F Z, Pinnock, R D, Lee, K

“…Gabapentin was originally designed as an anti-convulsant gamma-aminobutyric acid (GABA) mimetic capable of crossing the blood-brain barrier. In the present…”
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Hydrogen-Peroxide-Induced Toxicity of Rat Striatal Neurones Involves Activation of a Non-Selective Cation Channel by Smith, M. A., Herson, P. S., Lee, K., Pinnock, R. D., Ashford, M. L. J.

“…Striatal neurones are particularly vulnerable to hypoxia/ischaemia-induced damage, and free radicals are thought to be prime mediators of this neuronal…”
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Gabapentin inhibits excitatory synaptic transmission in the hyperalgesic spinal cord by Patel, Manoj K, Gonzalez, M Isabel, Bramwell, Steven, Pinnock, Robert D, Lee, Kevin

“…In the present study we tested the effects of the antihyperalgesic compound gabapentin on dorsal horn neurones in adult spinal cord. Slices were taken from…”
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Corticotropin-Releasing Factor Type 1 and Type 2α Receptors Regulate Phosphorylation of Calcium/Cyclic Adenosine 3′,5′-Monophosphate Response Element-Binding Protein and Activation of p42/p44 Mitogen-Activated Protein Kinase by Rossant, C. J, Pinnock, R. D, Hughes, J, Hall, M. D, McNulty, S

“…CRF exerts a key neuroregulatory control on the function of the hypothalamic-pituitary-adrenal axis. These effects are thought to be mediated primarily through…”
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Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression by MARTIN, D. J, MCCLELLAND, D, HERD, M. B, SUTTON, K. G, HALL, M. D, LEE, K, PINNOCK, R. D, SCOTT, R. H

“…We have used the whole cell patch clamp method and fura-2 fluorescence imaging to study the actions of gabapentin (1-(aminoethyl) cyclohexane acetic acid) on…”
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Development of a Class of Selective Cholecystokinin Type B Receptor Antagonists Having Potent Anxiolytic Activity by Hughes, J., Boden, P., Costall, B., Domeney, A., Kelly, E., Horwell, D. C., Hunter, J. C., Pinnock, R. D., Woodruff, G. N.

“…PD134308 and PD135158 are potent and selective antagonists at the cholecystokinin type B (CCK-B) receptors with IC50values of 1.6 nM and 3.5 nM, respectively,…”
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Bombesin-like peptides depolarize rat hippocampal interneurones through interaction with subtype 2 bombesin receptors by Lee, K., Dixon, A. K., Gonzalez, I., Stevens, E. B., McNulty, S., Oles, R., Richardson, P. J., Pinnock, R. D., Singh, L.

“…Whole-cell patch-clamp recordings were made from visually identified hippocampal interneurones in slices of rat brain tissue in vitro. Bath application of the…”
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PD 176252 — The first high affinity non-peptide gastrin-releasing peptide (BB 2) receptor antagonist by Ashwood, V., Brownhill, V., Higginbottom, M., Horwell, D.C., Hughes, J., Lewthwaite, R.A., McKnight, A.T., Pinnock, R.D., Pritchard, M.C., Suman-Chauhan, N., Webb, C., Williams, S.C.

“…In this paper we describe the development of a novel series of non-peptide, “balanced” neuromedin-B preferring (BB 1)/gastrin-releasing peptide preferring (BB…”
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Adenosine exerts multiple effects in dorsal horn neurones of the adult rat spinal cord by Patel, Manoj K, Pinnock, Robert D, Lee, Kevin

“…In the present study, we have examined the effects of adenosine and its analogues on the electrophysiological properties of dorsal horn neurones in the rat…”
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Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes by PRESTON, Z, LEE, K, WIDDOWSON, L, RICHARDSON, P. J, PINNOCK, R. D

“…Tachykinins have been suggested to play a significant role in the mammalian striatum, at least in part by the control of acetylcholine release from cholinergic…”
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Correlating Physiology with Gene Expression in Striatal Cholinergic Neurones by Richardson, Peter J., Dixon, Alistair K., Lee, Kevin, Bell, Matt I., Cox, Peter J., Williams, Richard, Pinnock, Robert D., Freeman, Tom C.

“…: The expression of 34 transmitter‐related genes has been examined in the cholinergic neurones of rat striatal brain slices, with the aim of correlating gene…”
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Serotonin depolarizes hippocampal interneurones in the rat stratum oriens by interaction with 5HT2 receptors by LEE, K, DIXON, A. K, PINNOCK, R. D

“…Patch-clamp recording techniques were used to examine the effect of serotonin (5HT) upon interneurones contained in the stratum oriens layer of hippocampal…”
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Dual effects of histamine and substance P on intracellular calcium levels in human U373 MG astrocytoma cells: role of protein kinase C by Young, K W., Pinnock, R D., Gibson, W J., Young, J M.

“…In human U373 MG astrocytoma cells agonist‐induced increases in intracellular Ca2+ ([Ca2+]i) are rapidly returned towards prestimulated levels. Examination of…”
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NK-3 receptors are expressed on mouse striatal γ-aminobutyric acid-ergic interneurones and evoke [ 3H] γ-aminobutyric acid release by Preston, Zoe, Richardson, Peter J, Pinnock, Robert D, Lee, Kevin

“…In the present study the ability of tachykinin agonists and antagonists to modulate γ-aminobutyric acid (GABA) release has been correlated with tachykinin…”
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Developmental expression of the novel voltage‐gated sodium channel auxiliary subunit β3, in rat CNS by Shah, B. S., Stevens, E. B., Pinnock, R. D., Dixon, A. K., Lee, K.

“…1 We have compared the mRNA distribution of sodium channel alpha subunits known to be expressed during development with the known auxiliary subunits Naβ1.1 and…”
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Activation of kappa-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro by Pinnock, R D

“…Intracellular recordings from dorsal raphé neurones in slices from rat brains were used to study the actions of kappa-opioid receptor agonists on an excitatory…”
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Neurotensin depolarizes substantia nigra dopamine neurones by Pinnock, R D

“…Neurotensin and the C-terminal 8-13 amino acid fragment were found to excite substantia nigra compacta dopamine neurones in vitro in a dose-dependent manner…”
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Modulation of Chemotropism in the Developing Spinal Cord by Substance P by De Felipe, Carmen, Pinnock, Robert D., Hunt, Stephen P.

“…Developing axons find their targets through direct contact with cues in the extracellular environment and in response to gradients of diffusible factors. The…”
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