Search Results - "Pinkevych, Mykola"

Predictors of SIV recrudescence following antiretroviral treatment interruption by Pinkevych, Mykola, Fennessey, Christine M, Cromer, Deborah, Reid, Carolyn, Trubey, Charles M, Lifson, Jeffrey D, Keele, Brandon F, Davenport, Miles P

“…There is currently a need for proxy measures of the HIV rebound competent reservoir (RCR) that can predict viral rebound after combined antiretroviral…”
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HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days--Implications for HIV Remission by Pinkevych, Mykola, Cromer, Deborah, Tolstrup, Martin, Grimm, Andrew J, Cooper, David A, Lewin, Sharon R, Søgaard, Ole S, Rasmussen, Thomas A, Kent, Stephen J, Kelleher, Anthony D, Davenport, Miles P

“…HIV infection can be effectively controlled by anti-retroviral therapy (ART) in most patients. However therapy must be continued for life, because interruption…”
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Modeling the dynamics of Plasmodium vivax infection and hypnozoite reactivation in vivo by Adekunle, Adeshina I, Pinkevych, Mykola, McGready, Rose, Luxemburger, Christine, White, Lisa J, Nosten, François, Cromer, Deborah, Davenport, Miles P

“…The dynamics of Plasmodium vivax infection is characterized by reactivation of hypnozoites at varying time intervals. The relative contribution of new P. vivax…”
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Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication by Pinkevych, Mykola, Docken, Steffen S, Okoye, Afam A, Fennessey, Christine M, Del Prete, Gregory Q, Pino, Maria, Harper, Justin L, Betts, Michael R, Paiardini, Mirko, Keele, Brandon F, Davenport, Miles P

“…One approach to 'functional cure' of HIV infection is to induce durable control of HIV replication after the interruption of antiretroviral therapy (ART)…”
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Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency by Docken, Steffen S, McCormick, Kevin, Pampena, M Betina, Samer, Sadia, Lindemuth, Emily, Pinkevych, Mykola, Viox, Elise G, Wu, Yuhuang, Schlub, Timothy E, Cromer, Deborah, Keele, Brandon F, Paiardini, Mirko, Betts, Michael R, Bar, Katharine J, Davenport, Miles P

“…HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8+ T cells may act to prevent early events in viral reactivation…”
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Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy by Fennessey, Christine M, Pinkevych, Mykola, Immonen, Taina T, Reynaldi, Arnold, Venturi, Vanessa, Nadella, Priyanka, Reid, Carolyn, Newman, Laura, Lipkey, Leslie, Oswald, Kelli, Bosche, William J, Trivett, Matthew T, Ohlen, Claes, Ott, David E, Estes, Jacob D, Del Prete, Gregory Q, Lifson, Jeffrey D, Davenport, Miles P, Keele, Brandon F

“…HIV and SIV infection dynamics are commonly investigated by measuring plasma viral loads. However, this total viral load value represents the sum of many…”
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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir by Keele, Brandon F, Okoye, Afam A, Fennessey, Christine M, Varco-Merth, Benjamin, Immonen, Taina T, Kose, Emek, Conchas, Andrew, Pinkevych, Mykola, Lipkey, Leslie, Newman, Laura, Macairan, Agatha, Bosche, Marjorie, Bosche, William J, Berkemeier, Brian, Fast, Randy, Hull, Mike, Oswald, Kelli, Shoemaker, Rebecca, Silipino, Lorna, Gorelick, Robert J, Duell, Derick, Marenco, Alejandra, Brantley, William, Smedley, Jeremy, Axthelm, Michael, Davenport, Miles P, Lifson, Jeffrey D, Picker, Louis J

“…The rebound competent viral reservoir (RCVR)-virus that persists during antiretroviral treatment (ART) and can reignite systemic infection when treatment is…”
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Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5-8 Days by Pinkevych, Mykola, Kent, Stephen J, Tolstrup, Martin, Lewin, Sharon R, Cooper, David A, Søgaard, Ole S, Rasmussen, Thomas A, Kelleher, Anthony D, Cromer, Deborah, Davenport, Miles P

“…The correlation between growth rate and time-to-detection in cohort 3 was in fact positive (r = 0.029, p = 0.9) despite an expected negative correlation. The…”
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The dynamics of naturally acquired immunity to Plasmodium falciparum infection by Pinkevych, Mykola, Petravic, Janka, Chelimo, Kiprotich, Kazura, James W, Moormann, Ann M, Davenport, Miles P

“…Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings. The…”
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Correction: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission by Pinkevych, Mykola, Cromer, Deborah, Tolstrup, Martin, Grimm, Andrew J, Cooper, David A, Lewin, Sharon R, Søgaard, Ole S, Rasmussen, Thomas A, Kent, Stephen J, Kelleher, Anthony D, Davenport, Miles P

“…[This corrects the article DOI: 10.1371/journal.ppat.1005000.][This corrects the article DOI: 10.1371/journal.ppat.1005740.][This corrects the article DOI:…”
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Impact of fluctuation in frequency of human immunodeficiency virus/simian immunodeficiency virus reactivation during antiretroviral therapy interruption by Wu, Yuhuang, Pinkevych, Mykola, Xu, Zhuang, Keele, Brandon F, Davenport, Miles P, Cromer, Deborah

“…Antiretroviral therapy (ART) provides effective control of human immunodeficiency virus (HIV) replication and maintains viral loads of HIV at undetectable…”
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Balancing Statistical Power and Risk in HIV Cure Clinical Trial Design by Lau, Jillian S Y, Cromer, Deborah, Pinkevych, Mykola, Lewin, Sharon R, Rasmussen, Thomas A, McMahon, James H, Davenport, Miles P

“…Abstract Background Analytical treatment interruptions (ATI) are pauses of antiretroviral therapy (ART) in the context of human immunodeficiency virus (HIV)…”
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Preferential selection of viral escape mutants by CD8.sup.+ T cell 'sieving' of SIV reactivation from latency by Docken, Steffen S, McCormick, Kevin, Pampena, M. Betina, Samer, Sadia, Lindemuth, Emily, Pinkevych, Mykola, Viox, Elise G, Wu, Yuhuang, Schlub, Timothy E, Cromer, Deborah, Keele, Brandon F, Paiardini, Mirko, Betts, Michael R, Bar, Katharine J, Davenport, Miles P

“…HIV rapidly rebounds after interruption of antiretroviral therapy (ART). HIV-specific CD8.sup.+ T cells may act to prevent early events in viral reactivation…”
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Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir by Brandon F. Keele, Afam A. Okoye, Christine M. Fennessey, Benjamin Varco-Merth, Taina T. Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J. Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J. Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P. Davenport, Jeffrey D. Lifson, Louis J. Picker

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CD8+ T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification by Okoye, Afam A, Duell, Derick D, Fukazawa, Yoshinori, Varco-Merth, Benjamin, Marenco, Alejandra, Behrens, Hannah, Chaunzwa, Morgan, Selseth, Andrea N, Gilbride, Roxanne M, Shao, Jason, Edlefsen, Paul T, Geleziunas, Romas, Pinkevych, Mykola, Davenport, Miles P, Busman-Sahay, Kathleen, Nekorchuk, Michael, Park, Haesun, Smedley, Jeremy, Axthelm, Michael K, Estes, Jacob D, Hansen, Scott G, Keele, Brandon F, Lifson, Jeffery D, Picker, Louis J

“…To define the contribution of CD8+ T cell responses to control of SIV reactivation during and following antiretroviral therapy (ART), we determined the effect…”
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Modeling of Antilatency Treatment in HIV: What Is the Optimal Duration of Antiretroviral Therapy-Free HIV Remission? by Cromer, Deborah, Pinkevych, Mykola, Rasmussen, Thomas A, Lewin, Sharon R, Kent, Stephen J, Davenport, Miles P

“…A number of treatment strategies are currently being developed to promote antiretroviral therapy-free HIV cure or remission. While complete elimination of the…”
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Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections by Liehl, Peter, Meireles, Patricia, S. Albuquerque, Inês, Pinkevych, Mykola, Baptista, Fernanda, Mota, Maria Manuel, Davenport, Miles P., Prudêncio, Miguel

“…© 2015 American Society for Microbiology. The authors have paid a fee to allow immediate free access to this article. Following transmission through a mosquito…”
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Estimating Initial Viral Levels during Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency by Pinkevych, Mykola, Fennessey, Christine M, Cromer, Deborah, Tolstrup, Martin, Søgaard, Ole S, Rasmussen, Thomas A, Keele, Brandon F, Davenport, Miles P

“…Human immunodeficiency virus (HIV) viremia rebounds rapidly after treatment interruption, and a variety of strategies are being explored to reduce or control…”
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T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification by Okoye, Afam A, Duell, Derick D, Fukazawa, Yoshinori, Varco-Merth, Benjamin, Marenco, Alejandra, Behrens, Hannah, Chaunzwa, Morgan, Selseth, Andrea N, Gilbride, Roxanne M, Shao, Jason, Edlefsen, Paul T, Geleziunas, Romas, Pinkevych, Mykola, Davenport, Miles P, Busman-Sahay, Kathleen, Nekorchuk, Michael, Park, Haesun, Smedley, Jeremy, Axthelm, Michael K, Estes, Jacob D, Hansen, Scott G, Keele, Brandon F, Lifson, Jeffery D, Picker, Louis J

“…To define the contribution of [CD8.sup.+] T cell responses to control of SIV reactivation during and following antiretroviral therapy (ART), we determined the…”
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Understanding the Relationship Between Plasmodium falciparum Growth Rate and Multiplicity of Infection by Pinkevych, Mykola, Petravic, Janka, Bereczky, Sandor, Rooth, Ingegerd, Färnert, Anna, Davenport, Miles P.

“…Natural infections with Plasmodium falciparum are often composed of multiple concurrent genetically distinct parasite clones. Such multidonal infections are…”
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