Search Results - "Pinilla, L."

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression by Vazquez, M. J., Toro, C. A., Castellano, J. M., Ruiz-Pino, F., Roa, J., Beiroa, D., Heras, V., Velasco, I., Dieguez, C., Pinilla, L., Gaytan, F., Nogueiras, R., Bosch, M. A., Rønnekleiv, O. K., Lomniczi, A., Ojeda, S. R., Tena-Sempere, M.

“…Puberty is regulated by epigenetic mechanisms and is highly sensitive to metabolic and nutritional cues. However, the epigenetic pathways mediating the effects…”
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Sex Steroids and the Control of the Kiss1 System: Developmental Roles and Major Regulatory Actions by García-Galiano, D., Pinilla, L., Tena-Sempere, M.

“…Kisspeptins, encoded by the Kiss1 gene, and their canonical receptor, GPR54 (also termed Kiss1R), are unanimously recognised as essential regulators of puberty…”
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On the oxidation degree of few-layer graphene oxide sheets obtained from chemically oxidized multiwall carbon nanotubes by Torres, D., Pinilla, J.L., Moliner, R., Suelves, I.

“…Multiwall carbon nanotubes (MWCNT), generated by catalytic decomposition of methane using a Fe–Mo/MgO catalyst, were subjected to oxidation and exfoliation…”
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Late in-the-bag intraocular lens dislocation requiring explantation: risk factors and outcomes by Fernández-Buenaga, R, Alio, J L, Pérez-Ardoy, A L, Larrosa-Quesada, A, Pinilla-Cortés, L, Barraquer, R, Alio, J L, Muñoz-Negrete, F J

“…Purpose To study the predisposing factors for late in-the-bag intraocular lens (IOL) dislocation and to analyze the outcomes after explantation surgery…”
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Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54 by Navarro, V. M., Fernández‐Fernández, R., Castellano, J. M., Roa, J., Mayen, A., Barreiro, M. L., Gaytan, F., Aguilar, E., Pinilla, L., Dieguez, C., Tena‐Sempere, M.

“…The awakening of the gonadotrophic axis at puberty is the end-point of a complex cascade of sex developmental events that leads to the attainment of…”
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AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction by Franssen, D., Barroso, A., Ruiz-Pino, F., Vázquez, M.J., García-Galiano, D., Castellano, J.M., Onieva, R., Ruiz-Cruz, M., Poutanen, M., Gaytán, F., Diéguez, C., Pinilla, L., Lopez, M., Roa, J., Tena-Sempere, M.

“…Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, master elements and final output pathway for the brain control of…”
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Metabolic Programming of Puberty: Sexually Dimorphic Responses to Early Nutritional Challenges by Sánchez-Garrido, M. A, Castellano, J. M, Ruiz-Pino, F, Garcia-Galiano, D, Manfredi-Lozano, M, Leon, S, Romero-Ruiz, A, Diéguez, C, Pinilla, L, Tena-Sempere, M

“…Body energy stores and metabolic cues influence the onset of puberty. However, the pubertal impact of early nutritional challenges has been only fragmentarily…”
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Critical Roles of Kisspeptins in Female Puberty and Preovulatory Gonadotropin Surges as Revealed by a Novel Antagonist by Pineda, R, Garcia-Galiano, D, Roseweir, A, Romero, M, Sanchez-Garrido, M. A, Ruiz-Pino, F, Morgan, K, Pinilla, L, Millar, R. P, Tena-Sempere, M

“…Kisspeptins (Kp) have recently emerged as master regulators of the reproductive axis and among the most potent elicitors of GnRH-gonadotropin secretion…”
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Novel signals for the integration of energy balance and reproduction by Fernandez-Fernandez, R., Martini, A.C., Navarro, V.M., Castellano, J.M., Dieguez, C., Aguilar, E., Pinilla, L., Tena-Sempere, M.

“…Although the close link between body weight and fertility has been known for eons, only recently have the peripheral signals and neuroendocrine networks…”
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The Mammalian Target of Rapamycin as Novel Central Regulator of Puberty Onset via Modulation of Hypothalamic Kiss1 System by Roa, J, Garcia-Galiano, D, Varela, L, Sánchez-Garrido, M. A, Pineda, R, Castellano, J. M, Ruiz-Pino, F, Romero, M, Aguilar, E, López, M, Gaytan, F, Diéguez, C, Pinilla, L, Tena-Sempere, M

“…The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that operates as sensor of cellular energy status and effector for its coupling to cell…”
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Characterization of the inhibitory roles of RFRP3, the mammalian ortholog of GnIH, in the control of gonadotropin secretion in the rat: in vivo and in vitro studies by Pineda, R, Garcia-Galiano, D, Sanchez-Garrido, M A, Romero, M, Ruiz-Pino, F, Aguilar, E, Dijcks, F A, Blomenröhr, M, Pinilla, L, van Noort, P I, Tena-Sempere, M

“…RF-amide related peptides (RFRP), as putative mammalian orthologs of the avian gonadotropin-inhibitory hormone (GnIH), have been proposed as key regulators of…”
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Hydrogen and multiwall carbon nanotubes production by catalytic decomposition of methane: Thermogravimetric analysis and scaling-up of Fe–Mo catalysts by Torres, D., Pinilla, J.L., Lázaro, M.J., Moliner, R., Suelves, I.

“…Fe-based catalysts doped with Mo were prepared and tested in the catalytic decomposition of methane (CDM), which aims for the co-production of CO2-free…”
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Changes in Hypothalamic KiSS-1 System and Restoration of Pubertal Activation of the Reproductive Axis by Kisspeptin in Undernutrition by Castellano, J. M, Navarro, V. M, Fernández-Fernández, R, Nogueiras, R, Tovar, S, Roa, J, Vazquez, M. J, Vigo, E, Casanueva, F. F, Aguilar, E, Pinilla, L, Dieguez, C, Tena-Sempere, M

“…Activation of the gonadotropic axis critically depends on sufficient body energy stores, and conditions of negative energy balance result in lack of puberty…”
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Kisspeptin treatment induces gonadotropic responses and rescues ovulation in a subset of preclinical models and women with polycystic ovary syndrome by Romero-Ruiz, A, Skorupskaite, K, Gaytan, F, Torres, E, Perdices-Lopez, C, Mannaerts, B M, Qi, S, Leon, S, Manfredi-Lozano, M, Lopez-Rodriguez, C, Avendaño, M S, Sanchez-Garrido, M A, Vazquez, M J, Pinilla, L, van Duin, M, Kohout, T A, Anderson, R A, Tena-Sempere, M

“…Abstract STUDY QUESTION Can kisspeptin treatment induce gonadotrophin responses and ovulation in preclinical models and anovulatory women with polycystic ovary…”
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Developmental and Hormonally Regulated Messenger Ribonucleic Acid Expression of KiSS-1 and Its Putative Receptor, GPR54, in Rat Hypothalamus and Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide by Navarro, V. M, Castellano, J. M, Fernández-Fernández, R, Barreiro, M. L, Roa, J, Sanchez-Criado, J. E, Aguilar, E, Dieguez, C, Pinilla, L, Tena-Sempere, M

“…The gonadotropic axis is centrally controlled by a complex regulatory network of excitatory and inhibitory signals that is activated at puberty. Recently, loss…”
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Cellular Distribution, Regulated Expression, and Functional Role of the Anorexigenic Peptide, NUCB2/Nesfatin-1, in the Testis by García-Galiano, D, Pineda, R, Ilhan, T, Castellano, J. M, Ruiz-Pino, F, Sánchez-Garrido, M. A, Vazquez, M. J, Sangiao-Alvarellos, S, Romero-Ruiz, A, Pinilla, L, Diéguez, C, Gaytán, F, Tena-Sempere, M

“…Nesfatin-1, product of the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a…”
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Effects and Interactions of Tachykinins and Dynorphin on FSH and LH Secretion in Developing and Adult Rats by Ruiz-Pino, F, Garcia-Galiano, D, Manfredi-Lozano, M, Leon, S, Sánchez-Garrido, M. A, Roa, J, Pinilla, L, Navarro, V. M, Tena-Sempere, M

“…Kisspeptin/neurokinin B/dynorphin (KNDy) neurons, which coexpress kisspeptins (Kps), neurokinin B (NKB), and dynorphin (Dyn), regulate gonadotropin secretion…”
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KiSS-1/kisspeptins and the metabolic control of reproduction: Physiologic roles and putative physiopathological implications by Castellano, J.M., Roa, J., Luque, R.M., Dieguez, C., Aguilar, E., Pinilla, L., Tena-Sempere, M.

“…It is well established that reproductive function is gated by the state of energy reserves of the organism; conditions of metabolic stress and energy…”
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Regulation of NKB Pathways and Their Roles in the Control of Kiss1 Neurons in the Arcuate Nucleus of the Male Mouse by Navarro, V. M, Gottsch, M. L, Wu, M, García-Galiano, D, Hobbs, S. J, Bosch, M. A, Pinilla, L, Clifton, D. K, Dearth, A, Ronnekleiv, O. K, Braun, R. E, Palmiter, R. D, Tena-Sempere, M, Alreja, M, Steiner, R. A

“…Kisspeptin (Kiss1) and neurokinin B (NKB) (encoded by the Kiss1 and Tac2 genes, respectively) are indispensable for reproduction. In the female of many…”
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Expression of KiSS-1 in Rat Ovary: Putative Local Regulator of Ovulation? by Castellano, J. M, Gaytan, M, Roa, J, Vigo, E, Navarro, V. M, Bellido, C, Dieguez, C, Aguilar, E, Sánchez-Criado, J. E, Pellicer, A, Pinilla, L, Gaytan, F, Tena-Sempere, M

“…Kisspeptins, the products of KiSS-1 gene, and their receptor, GPR54, have recently emerged as essential gatekeepers of reproduction, mainly through regulation…”
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